{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:21:25Z","timestamp":1761708085505,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:p>The cerebellar, retinal, and one of the spinal haemangioblastomas in a case of von Hippel-Lindau syndrome were studied by immunocytochemistry and electron microscopy. The tumours were positive for neurone specific enolase and variably positive for somatostatin, pancreatic polypeptide, and bombesin. Electron microscopy of the cerebellar tumour showed secretory granules with an average diameter of 170 nm. This report is believed to be the first description of neurone specific enolase positivity and polypeptide hormones within the intervascular cells of haemangioblastomas. In the light of these findings it is suggested that haemangioblastomas are tumours of neuroectodermal origin, derived either from neural or neuroendocrine cells.<\/jats:p>","DOI":"10.1136\/jcp.38.4.417","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"417-421","source":"Crossref","is-referenced-by-count":22,"title":["Histogenesis of haemangioblastomas: an immunocytochemical and ultrastructural study in a case of von Hippel-Lindau syndrome."],"prefix":"10.1136","volume":"38","author":[{"given":"S M","family":"Ismail","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Jasani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1002\/1097-0142(197910)44:4<1523::AID-CNCR2820440452>3.0.CO;2-0","article-title":"Familial islet cell tumours in von Hippel-Lindau's disease","volume":"44","author":"Hull, M.T.; Wastel, K.A.; Muller, J.; Higgins, J.T.","year":"1979","unstructured":"Hull MT, Wastel KA, Muller J, Higgins JT. 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DNP-hapten sandwich staining (DHSS) procedure: design, sensitivity, versatility and applications. Immunology Communications 1983; 12:57.","journal-title":"J Neurosurg; Use of monoclonal antihapten antibodies for immunolocalization of tissue antigens"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3171\/jns.1952.9.4.0317","article-title":"The cerebellar angioreticulomas","volume":"9","author":"Olivecrona, H.","year":"1952","unstructured":"Olivecrona H. The cerebellar angioreticulomas. J Neurosurg 1952;9:317-30.","journal-title":"J Neurosurg"},{"key":"ref_10","first-page":"259","article-title":"Phaeochromocytoma associated with cerebellar haemangioblastoma. Familial occurrence. JAMA 1962; 182: 1014-7. \"","volume":"4","author":"Chapman, R.C.; Diaz-Perez, R.","year":"1971","unstructured":"Chapman RC, Diaz-Perez R. Phaeochromocytoma associated with cerebellar haemangioblastoma. Familial occurrence. JAMA 1962; 182:1014-7. \" Sander S, Normann T, Martinsen W. Phaeochromocytoma associated with von Hippel-Lindau's disease in a family. Scand J Urol Nephrol 1971;4:259-63.","journal-title":"Phaeochromocytoma associated with von Hippel-Lindau's disease in a family; Scand J Urol Nephrol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/path.1711370105","article-title":"Enolase isoenzyme distribution in the human brain and its tumours","volume":"137","author":"Royds, J.A.; Parsons, M.A.; Taylor, C.B.; Timperley, W.R.","year":"1982","unstructured":"Royds JA, Parsons MA, Taylor CB, Timperley WR. Enolase isoenzyme distribution in the human brain and its tumours. J Pathol 1982; 137:37-49.","journal-title":"J Pathol"},{"key":"ref_12","first-page":"313","article-title":"Brain enolases as specific markers of neuronal and glial cells","author":"Schmechel, D.; Marangos, P.J.; Zis, A.P.; Brightman, M.; Goodwin, F.K.","year":"1978","unstructured":"Schmechel D, Marangos PJ, Zis AP, Brightman M, Goodwin FK. 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Intrinsic haematopoietic activity of cerebellar haemangioblastomas. Ultrastructural study of three cases. Neurochirurgia 1979;22:24-38.","journal-title":"Neurochirurgia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"\"51","DOI":"10.1146\/annurev.me.29.020178.000411","article-title":"Erythropoietin and the control of red cell production","volume":"29","author":"Graber, S.E.; Krantz, S.B.","year":"1978","unstructured":"Graber SE, Krantz SB. Erythropoietin and the control of red cell production. Ann Rev Med 1978;29:51-66. 2' Hokfelt T, Johannson 0, Ljungdahl A, Lundberg JM, Schultzberg M. Peptidergic neurones. 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