{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:39:12Z","timestamp":1760146752683,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,6]]},"abstract":"<jats:p>A further type II variant of von Willebrand's disease has been identified in five family members who have the clinical symptoms of von Willebrand's disease. This variant is characterised by loss of high molecular weight VIIIR:AG multimers and the replacement of the normal triplet multimer configuration by a single dense band. In addition, variable minor bands are seen. These variants appear similar to those recently reported by Kinoshita et al and designated as type IID.<\/jats:p>","DOI":"10.1136\/jcp.38.6.665","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"665-670","source":"Crossref","is-referenced-by-count":13,"title":["Investigation of a kindred with a new autosomal dominantly inherited variant type von Willebrand's disease (possible type IID)."],"prefix":"10.1136","volume":"38","author":[{"given":"F G","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Enayat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1985,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2141.1974.tb00484.x","article-title":"A variant of factor VIIIrelated antigen","volume":"26","author":"Kernoff, P.B.A.; Gruson, R.; Rizza, C.R.","year":"1974","unstructured":"Kernoff PBA, Gruson R, Rizza CR. A variant of factor VIIIrelated antigen. Br J Haematol 1974;26:435-40.","journal-title":"Br J Haematol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJM197407182910301","article-title":"Inherited variants of factor VIII-related protein in von Willebrand's disease","volume":"291","author":"Peak, I.R.; Bloom, A.L.; Giddings, J.C.","year":"1974","unstructured":"Peak IR, Bloom AL, Giddings JC. Inherited variants of factor VIII-related protein in von Willebrand's disease. N Engi J Med 1974;291:113-7.","journal-title":"N Engi J Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI109795","article-title":"Variant von Willebrand's disease: Characterization of two subtypes by analysis of multimeric composition of factor VIII\/von Willebrand factor in plasma and platelets","volume":"65","author":"Ruggeri, Z.M.; Zimmerman, T.S.","year":"1980","unstructured":"Ruggeri ZM, Zimmerman TS. Variant von Willebrand's disease: Characterization of two subtypes by analysis of multimeric composition of factor VIII\/von Willebrand factor in plasma and platelets. J Clin Invest 1980;65: 1318-25.","journal-title":"J Clin Invest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1182\/blood.V57.6.1140.1140","article-title":"The complex multimeric composition of factor VIII\/von Willebrand factor","volume":"57","author":"Ruggeri, Z.M.; Zimmerman, T.S.","year":"1981","unstructured":"Ruggeri ZM, Zimmerman TS. The complex multimeric composition of factor VIII\/von Willebrand factor. Blood 1981; 57:1140-3.","journal-title":"Blood"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1056\/NEJM198005083021902","article-title":"Heightened interaction between platelets and factor VIII\/ von Willebrand factor in a new subtype of von Willebrand's disease","volume":"302","author":"Ruggeri, Z.M.; Pareti, F.I.; Mannucci, P.M.; Ciavarella, N.; Zimmerman, T.S.","year":"1980","unstructured":"Ruggeri ZM, Pareti FI, Mannucci PM, Ciavarella N, Zimmerman TS. Heightened interaction between platelets and factor VIII\/ von Willebrand factor in a new subtype of von Willebrand's disease. N Engl J Med 1980;302:1047-5 1.","journal-title":"N Engl J Med"},{"key":"ref_6","first-page":"194","article-title":"ELISA factor VIII related antigen assay","volume":"37","year":"1984","unstructured":"ELISA factor VIII related antigen assay. J Clin Pathol 1984;37: 194-9.","journal-title":"J Clin Pathol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1172\/JCI110700","article-title":"Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (Type IIC)","volume":"70","author":"Ruggeri, Z.M.; Nilsson, I.M.; Lombardi, R.; Holmberg, L.; Zimmerman, T.S.","year":"1982","unstructured":"Ruggeri ZM, Nilsson IM, Lombardi R, Holmberg L, Zimmerman TS. Aberrant multimeric structure of von Willebrand factor in a new variant of von Willebrand's disease (Type IIC). J Clin Invest 1982;70:1124-7.","journal-title":"J Clin Invest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1182\/blood.V62.5.1000.1000","article-title":"A variant of von Willebrand's disease characterized by recessive inheritance and missing triplet structure of von Willebrand factor multimers","volume":"62","author":"Mannucci, P.M.; Lombardi, R.; Pareti, F.I.; Solinas, S.; Mazzucconi, M.G.; Mariani, G.","year":"1983","unstructured":"Mannucci PM, Lombardi R, Pareti FI, Solinas S, Mazzucconi MG, Mariani G. A variant of von Willebrand's disease characterized by recessive inheritance and missing triplet structure of von Willebrand factor multimers. Blood 1983;62: 1000-5.","journal-title":"Blood"},{"key":"ref_9","first-page":"119","article-title":"A new variant of dominant type II von Willebrand's disease with aberrant multimeric pattern of factor VIII related antigen (type IID). Blood 1984; 63: 1369-71. '0 Hutton RA, Howard MA, Deykin D, Hardisty RM. Methods for the separation of platelets from plasma. A comparison of functional and morphological integrity","volume":"31","author":"Kinoshita, S.; Harrison, J.; Lazerson, J.; Abildgaard, C.F.","year":"1974","unstructured":"Kinoshita S, Harrison J, Lazerson J, Abildgaard CF. A new variant of dominant type II von Willebrand's disease with aberrant multimeric pattern of factor VIII related antigen (type IID). Blood 1984; 63: 1369-71. '0 Hutton RA, Howard MA, Deykin D, Hardisty RM. Methods for the separation of platelets from plasma. A comparison of functional and morphological integrity. Thrombos Diathes Haemorrh 1974;31: 119-32.","journal-title":"Thrombos Diathes Haemorrh"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-2141.1959.tb04009.x","article-title":"Assay of plasma antihaemophilic globulin (AHG)","volume":"5","author":"Pool, J.G.; Robinson, J.","year":"1959","unstructured":"Pool JG, Robinson J. Assay of plasma antihaemophilic globulin (AHG). Br J Haematol 1959;5:17-23.","journal-title":"Br J Haematol"},{"key":"ref_11","first-page":"224","article-title":"Immunologic differentiation of classic haemophilia (factor VIII deficiency) and von Willebrand's disease with observations on combined deficiencies of antihaemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against haemophilic factor","volume":"50","author":"Zimmerman, T.S.; Ratnoff, O.D.; Powell, A.E.","year":"1971","unstructured":"Zimmerman TS, Ratnoff OD, Powell AE. Immunologic differentiation of classic haemophilia (factor VIII deficiency) and von Willebrand's disease with observations on combined deficiencies of antihaemophilic factor and proaccelerin (factor V) and on an acquired circulating anticoagulant against haemophilic factor. J Clin Invest 1971; 50:224-54.","journal-title":"J Clin Invest"},{"key":"ref_12","first-page":"2708","article-title":"Qualitative VIIIR: AG function screening of multiple samples by two dimensional crossed immunoelectrophoresis technique","volume":"52","author":"Enayat, M.S.; Hill, F.G.H.","year":"1982","unstructured":"Enayat MS, Hill FGH. Qualitative VIIIR:AG function screening of multiple samples by two dimensional crossed immunoelectrophoresis technique. Med Lab Sci 1982;39:357-62. ' Weiss HJ, Hoyer LW, Rickles FR, Varma A, Rogers J. Quantitative assay of a plasma factor deficient in von Willebrand's disease that is necessary for platelet aggregation. Relationship to factor VIII procoagulant activity and antigen content. J Clin Invest 1973;52:2708-10.","journal-title":"Med Lab Sci; 39: 357-62. ' Weiss HJ, Hoyer"},{"key":"ref_13","first-page":"276","article-title":"von Willebrand's syndrome. Studies on a variant factor VIII","volume":"5","author":"Hill, F.G.H.; Chan, M.C.K.; Hardisty, R.M.","year":"1976","unstructured":"Hill FGH, Chan MCK, Hardisty RM. von Willebrand's syndrome. Studies on a variant factor VIII. Haemostasis 1976;5:276-84.","journal-title":"Haemostasis"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1136\/jcp.36.8.915","article-title":"Analysis of the complexity of the multimeric structure of FVIII related antigen\/von Willebrand protein using a modified electrophoretic technique","volume":"36","author":"Enayat, M.S.; Hill, F.G.H.","year":"1983","unstructured":"Enayat MS, Hill FGH. Analysis of the complexity of the multimeric structure of FVIII related antigen\/von Willebrand protein using a modified electrophoretic technique. J Clin Pathol 1983;36:915-9.","journal-title":"J Clin Pathol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2141.1979.tb05856.x","article-title":"Two populations of factor VIII-related antigen in a family with von Willebrand's disease","volume":"41","author":"Armitage, H.; Rizza, C.R.","year":"1979","unstructured":"Armitage H, Rizza CR. Two populations of factor VIII-related antigen in a family with von Willebrand's disease. Br J Haematol 1979;41:279-89.","journal-title":"Br J Haematol"},{"key":"ref_16","first-page":"177","article-title":"Multimeric analysis of von Willebrand protein (VIIIR: AG); application to the diagnosis and treatment of patients with von Willebrandcs disease","volume":"58","author":"Hill, F.G.H.; Enayat, M.S.","year":"1984","unstructured":"Hill FGH, Enayat MS. Multimeric analysis of von Willebrand protein (VIIIR:AG); application to the diagnosis and treatment of patients with von Willebrandcs disease. (Abstract). Br J Haematol 1984;58:177.","journal-title":"(Abstract). Br J Haematol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.38.6.665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:33:28Z","timestamp":1758789208000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.38.6.665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,6]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1985,6,1]]},"published-print":{"date-parts":[[1985,6]]}},"alternative-id":["10.1136\/jcp.38.6.665"],"URL":"https:\/\/doi.org\/10.1136\/jcp.38.6.665","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1985,6]]}}}