{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:39:27Z","timestamp":1787647167996,"version":"build-2736575974"},"reference-count":29,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:p>Endometrial biopsies were obtained from 32 women with suspected pelvic inflammatory disease, of whom 23 (72%) had histopathological evidence of endometritis. Chlamydia trachomatis was isolated from the endometria of nine (39%) women (chlamydia group) but not from the other 14 (non-chlamydia group). Severe plasma cell endometritis and lymphoid follicles with transformed lymphocytes were significantly more common in the chlamydia group than in the non-chlamydia group. This suggests that C trachomatis is an invasive endometrial pathogen which often causes severe inflammation. The association was independent of predisposing factors such as use of intrauterine contraceptive devices.<\/jats:p>","DOI":"10.1136\/jcp.38.7.726","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"726-732","source":"Crossref","is-referenced-by-count":58,"title":["Chlamydial endometritis."],"prefix":"10.1136","volume":"38","author":[{"given":"J","family":"Paavonen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Aine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Teisala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P K","family":"Heinonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Punnonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lehtinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Miettinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Gr\u00f6nroos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1985,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1056\/NEJM197706162962403","article-title":"Chiamydia trachomatis infection in patients with acute salpingitis","volume":"296","author":"Mardh, P.-A.; Ripa, K.T.; Svensson, I.; Westrom, L.","year":"1977","unstructured":"Mardh P-A, Ripa KT, Svensson I, Westrom L. 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Stain Technol 1963;38:204-5."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/10520297209116529","article-title":"Methyl green-pyronin staining: Effects of fixation; use in routine pathology","volume":"47","author":"Ahlquist, J.; Andersson, L.","year":"1972","unstructured":"Ahlquist J, Andersson L. Methyl green-pyronin staining: Effects of fixation; use in routine pathology. Stain Technol 1972; 47:17-22.","journal-title":"Stain Technol"},{"issue":"328-32","key":"ref_13","first-page":"\"4Peacock\" # \"733","article-title":"Cultivation of Chlamydia trachomatis in cycloheximide-treated McCoy cells","volume":"6","author":"Ripa, K.T.; Mardh, P.-A.","year":"1977","unstructured":"Ripa KT, Mardh P-A. Cultivation of Chlamydia trachomatis in cycloheximide-treated McCoy cells. J Clin Microbiol 1977; 6:328-32. 4Peacock WL Jr. Method for preparing N. gonorrhoeae fluorescent antibody conjugate. Public Health Rep 1970;85: 733-8. -Tully JG, Whitcomb RF, Clark HF, Williamson DL. Pathogenic mycoplasmas: Cultivations and vertebrate pathogenicity of a new spiroplasma. Science 1977; 195:892-4.","journal-title":"J Clin Microbiol; Method for preparing N. gonorrhoeae fluorescent antibody conjugate"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1128\/jcm.8.5.566-574.1978","article-title":"Serologic typing of Ureaplasma urealyticum isolates from urethritis patients by an agar growth inhibition method","volume":"8","author":"Shepard, M.C.; Lunceford, C.D.","year":"1978","unstructured":"Shepard MC, Lunceford CD. Serologic typing of Ureaplasma urealyticum isolates from urethritis patients by an agar growth inhibition method. J Clin Microbiol 1978;8:566-74.","journal-title":"J Clin Microbiol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"958","DOI":"10.4049\/jimmunol.92.6.958","article-title":"Mycoplasma species identification based upon growth inhibition by septic antisera","volume":"92","author":"Clyde, W.A.","year":"1964","unstructured":"Clyde WA. Mycoplasma species identification based upon growth inhibition by septic antisera. J Immunol 1964; 92:958-63.","journal-title":"J Immunol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1128\/jcm.3.6.613-625.1976","article-title":"for identification Ureaplasma urealyticum (human T-mycoplasmas) in primary cultures of clinical material","volume":"3","year":"1976","unstructured":"for identification Ureaplasma urealyticum (human T-mycoplasmas) in primary cultures of clinical material. 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Obstet Gynecol 1985:65:288-91.","journal-title":"Obstet Gynecol"},{"key":"ref_19","first-page":"119","article-title":"Endometritis and infertility","volume-title":"Fertil Steril","volume":"30","author":"Czernobilsky, B.","year":"1978","unstructured":"Czernobilsky B. Endometritis and infertility. Fertil Steril 1978;30: 119-30."},{"key":"ref_20","first-page":"176","article-title":"Chronic endometritis: Morphologic and clinical observations","volume":"58","author":"Greenwood, S.M.; Moran, J.J.","year":"1981","unstructured":"Greenwood SM, Moran JJ. Chronic endometritis: Morphologic and clinical observations. Obstet Gynecol 1981;58: 176-84.","journal-title":"Obstet Gynecol"},{"key":"ref_21","first-page":"209","article-title":"Chronic endometritis. A clinicopathologic study","volume":"13","author":"Rotterdam, H.","year":"1978","unstructured":"Rotterdam H. Chronic endometritis. A clinicopathologic study. Pathol Ann 1978;13:209-31.","journal-title":"Pathol Ann"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"\"21","DOI":"10.3109\/00016348209156945","article-title":"Infertility and uterine colonization with Ureaplasma urealyticum","volume":"62","author":"Stray-Pedersen, B.; Bruu, A.L.; Molne, K.","year":"1982","unstructured":"Stray-Pedersen B, Bruu AL, Molne K. Infertility and uterine colonization with Ureaplasma urealyticum. Acta Obstet Gynecol Scand 1982;62:21-4. 2S Runge H. Gonorrhoe der weiblichen Geschlectsorgane. In: Seitz L, Amreich AJ, eds. Biologie und Pathologie des Weibes, vol V. Berlin: Urban and Schwarzenberg, 1953:445-50.","journal-title":"Acta Obstet Gynecol Scand; Gonorrhoe der weiblichen Geschlectsorgane"},{"key":"ref_23","first-page":"267","article-title":"Diseases of the outer eye","volume-title":"System of ophthalmology. Vol VIII","author":"Duke-Elder, S.","year":"1965","unstructured":"Duke-Elder S. Diseases of the outer eye. In: Duke-Elder S, ed. System of ophthalmology. Vol VIII London: Henry Kimpton. 1965: 267-80."},{"key":"ref_24","first-page":"235","article-title":"Chronic lymphocytic cervicitis: cytologic and histopathologic manifestations","volume":"19","author":"Roberts, T.H.; Ng, A.B.P.","year":"1975","unstructured":"Roberts TH, Ng ABP. Chronic lymphocytic cervicitis: cytologic and histopathologic manifestations. Acta Cytol 1975; 19:235-43.","journal-title":"Acta Cytol"},{"key":"ref_25","first-page":"17480","article-title":"Follicular cervicitis-Colposcopic appearances and association with Chlamydia trachomatis","volume":"88","author":"Hare, M.J.; Toone, E.; Taylor-Robinson, D.","year":"1981","unstructured":"Hare MJ, Toone E, Taylor-Robinson D, et al. Follicular cervicitis-Colposcopic appearances and association with Chlamydia trachomatis. Br J Obstet Gynaecol 1981;88: 17480.","journal-title":"Br J Obstet Gynaecol"},{"key":"ref_26","first-page":"712","article-title":"Colposcopic and histologic findings in cervical chlamydial infection","volume":"59","author":"Paavonen, J.; Vesterinen, E.; Mayer, B.; Saksela, E.","year":"1982","unstructured":"Paavonen J, Vesterinen E, Mayer B, Saksela E. Colposcopic and histologic findings in cervical chlamydial infection. Obstet Gynecol 1982;59:712-4.","journal-title":"Obstet Gynecol"},{"key":"ref_27","first-page":"174","article-title":"Cytologic findings in cervical chlamydial infection","volume":"58","author":"Paavonen, J.; Purola, E.","year":"1980","unstructured":"Paavonen J, Purola E. Cytologic findings in cervical chlamydial infection. Med Biol 1980;58: 174-8.","journal-title":"Med Biol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1128\/IAI.43.1.84-92.1984","article-title":"Chlamydia trachomatis stimulates human peripheral blood B lymphocytes to proliferate and secrete polyclonal immunoglobulin in vitro","volume":"43","author":"Bard, J.; Levitt, D.","year":"1984","unstructured":"Bard J, Levitt D. Chlamydia trachomatis stimulates human peripheral blood B lymphocytes to proliferate and secrete polyclonal immunoglobulin in vitro. Infect Immun 1984;43:84-92.","journal-title":"Infect Immun"},{"key":"ref_29","first-page":"656","article-title":"Chlamydial serology in infertile women by immunofluorescence","volume-title":"Fertil Steril","volume":"31","year":"1979","unstructured":"Punnonen R, Terho P, Nikkanen V, Meurman 0. Chlamydial serology in infertile women by immunofluorescence. Fertil Steril 1979;31:656-9."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.38.7.726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:16:04Z","timestamp":1765725364000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.38.7.726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1985,7,1]]},"published-print":{"date-parts":[[1985,7]]}},"alternative-id":["10.1136\/jcp.38.7.726"],"URL":"https:\/\/doi.org\/10.1136\/jcp.38.7.726","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,7]]}}}