{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:13:46Z","timestamp":1780319626686,"version":"3.54.1"},"reference-count":13,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1986,2]]},"abstract":"<jats:p>The results of the Coulter counter S plus II platelet volume analysis were studied in 100 patients with reactive thrombocytosis (platelet count greater than 500 X 10(9)\/l), in 30 patients with myeloproliferative thrombocytosis, and in 32 patients with chronic myeloproliferative disease and a platelet count less than 500 X 10(9)\/l. Patients with reactive thrombocytosis had considerably lower mean platelet volumes than those with myeloproliferative thrombocytosis, or normal subjects. The opposite was true for the platelet distribution width. This index for platelet heterogeneity was normal in reactive, but increased in myeloproliferative thrombocytosis. There were no differences in mean platelet volume or platelet distribution width between patients with myeloproliferative disease and a high or normal platelet count. The increased platelet heterogeneity in myeloproliferative disease was caused by an increase of both small and large platelets. The platelet distribution width seemed to be the best variable for the differential diagnosis of thrombocytosis. A platelet distribution width greater than 17 was found in 26 of the 30 patients with myeloproliferative thrombocytosis but in only five of the 100 patients with reactive thrombocytosis. A normal platelet distribution width in a patient with a high platelet count strongly suggests reactive thrombocytosis.<\/jats:p>","DOI":"10.1136\/jcp.39.2.129","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"129-133","source":"Crossref","is-referenced-by-count":28,"title":["Platelet volume analysis for differential diagnosis of thrombocytosis."],"prefix":"10.1136","volume":"39","author":[{"given":"J","family":"Van der Lelie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A K","family":"Von dem Borne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000206719","article-title":"Thrombocytosis and microthrombocytosis: a clinical evaluation of 372 cases","volume":"70","author":"Robbins, G.; Barnard, D.L.","year":"1983","unstructured":"Robbins G, Barnard DL. Thrombocytosis and microthrombocytosis: a clinical evaluation of 372 cases. Acta Haematol 1983;70:175-82.","journal-title":"Acta Haematol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0308-2261(21)00376-3","article-title":"Thrombocytosis and thrombocythaemia","volume":"12","author":"Murphy, S.","year":"1983","unstructured":"Murphy S. Thrombocytosis and thrombocythaemia. Clin Haematol 1983;12:89-106.","journal-title":"Clin Haematol"},{"key":"ref_3","first-page":"29","article-title":"The Coulter counter model S plus -the shape of things to come","volume":"1","author":"Rowan, R.M.; Fraser, C.; Gray, J.H.; McDonald, G.A.","year":"1979","unstructured":"Rowan RM, Fraser C, Gray JH, McDonald GA. The Coulter counter model S plus -the shape of things to come. 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N Engl J Med 1971;284:1 1-7.","journal-title":"N Engl J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/s-0038-1650032","article-title":"Abnormal aggregation and increased size of platelets in myeloproliferative disorders","volume":"43","author":"Cortelazzo, S.; Barbui, T.; Bassan, R.; Dini, E.","year":"1980","unstructured":"Cortelazzo S, Barbui T, Bassan R, Dini E. Abnormal aggregation and increased size of platelets in myeloproliferative disorders. Thromb Hemost 1980;43:127-30.","journal-title":"Thromb Hemost"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1182\/blood.V51.3.479.479","article-title":"Microscopic platelet size and morphology in various hematologic disorders","volume":"51","author":"Zeigler, Z.; Murphy, S.; Gardner, F.H.","year":"1978","unstructured":"Zeigler Z, Murphy S, Gardner FH. Microscopic platelet size and morphology in various hematologic disorders. Blood 1978;51: 479-86.","journal-title":"Blood"},{"key":"ref_8","first-page":"610","article-title":"Comparative measurements of platelet size by Coulter counter, microscopy of blood smears, and light transmission studies","volume":"97","author":"Holme, S.; Simmonds, M.; Ballek, R.; Murphy, S.","year":"1981","unstructured":"Holme S, Simmonds M, Ballek R, Murphy S. Comparative measurements of platelet size by Coulter counter, microscopy of blood smears, and light transmission studies. J Lab Clin Med 1981;97:610-22.","journal-title":"J Lab Clin Med"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/ajcp\/76.5.685","article-title":"Diagnosis of myeloproliferative disease by analysis of the platelet volume distribution","volume":"76","author":"Small, B.M.; Bettigole, R.E.","year":"1981","unstructured":"Small BM, Bettigole RE. Diagnosis of myeloproliferative disease by analysis of the platelet volume distribution. Am J Clin Pathol 1981;76:685-91.","journal-title":"Am J Clin Pathol"},{"key":"ref_10","first-page":"373","article-title":"Studies on the platelet density abnormality in myeloproliferative disease","volume":"103","author":"Holme, S.; Murphy, S.","year":"1984","unstructured":"Holme S, Murphy S. Studies on the platelet density abnormality in myeloproliferative disease. J Lab Clin Med 1984;103:373-83.","journal-title":"J Lab Clin Med"},{"key":"ref_11","first-page":"329","article-title":"Density distribution and size of megakaryocytes in inflammatory reactions of the bonemarrow (myelitis) and chronic myeloproliferative diseases","volume":"31","author":"Thiele, J.; Holgado, S.; Choritz, H.; Georgii, A.","year":"1983","unstructured":"Thiele J, Holgado S, Choritz H, Georgii A. Density distribution and size of megakaryocytes in inflammatory reactions of the bonemarrow (myelitis) and chronic myeloproliferative diseases. Scand J Haematol 1983;31:329-41.","journal-title":"Scand J Haematol"},{"key":"ref_12","first-page":"295","article-title":"The inverse relation between platelet volume and platelet number","volume":"101","author":"Levin, J.; Bessman, J.D.","year":"1983","unstructured":"Levin J, Bessman JD. The inverse relation between platelet volume and platelet number. J Lab Clin Med 1983;101:295-307.","journal-title":"J Lab Clin Med"},{"key":"ref_13","article-title":"Clinical epidemiologythe essentials","author":"Fletcher, R.H.; Fletcher, S.W.; Wagner, E.H.","year":"1982","unstructured":"Fletcher RH, Fletcher SW, Wagner EH. Clinical epidemiologythe essentials. London: Williams and Wilkins, 1982."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.39.2.129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:03:27Z","timestamp":1765073007000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.39.2.129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1986,2,1]]},"published-print":{"date-parts":[[1986,2]]}},"alternative-id":["10.1136\/jcp.39.2.129"],"URL":"https:\/\/doi.org\/10.1136\/jcp.39.2.129","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2]]}}}