{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:01:29Z","timestamp":1770508889969,"version":"3.49.0"},"reference-count":16,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1986,2]]},"abstract":"<jats:p>The serum concentrations of \"pregnancy-associated\" alpha 2-glycoprotein (alpha 2-PAG) were measured in 129 healthy women and 141 healthy men to establish a normal range, using a sensitive enzyme linked immunosorbent assay. In the normal population 2.8% of men and 5.4% of women had low serum alpha 2-PAG concentrations. Low concentrations occur, however, much more commonly in patients, particularly male patients, with certain diseases, including dermatitis herpetiformis (three of 12 or 25%) and urticaria (two of five or 40%). One female patient with absolute deficiency was also identified. In view of the recently confirmed association of alpha 2-PAG with IgA and the fact that alpha 2-PAG seems to have immunosuppressive properties, it seems likely that deficiency of alpha 2-PAG could result in the subject becoming sensitised to various dietary antigens. Interestingly, none of the 24 patients with IgA deficiency showed concomitant deficiency of alpha 2-PAG.<\/jats:p>","DOI":"10.1136\/jcp.39.2.195","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"195-198","source":"Crossref","is-referenced-by-count":2,"title":["Deficiency of serum \"pregnancy-associated\" alpha 2-glycoprotein alpha 2-PAG): association with disease."],"prefix":"10.1136","volume":"39","author":[{"given":"C H","family":"Horne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L M","family":"Gerrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P W","family":"Brunt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N A","family":"Mowat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T S","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,2,1]]},"reference":[{"key":"ref_1","first-page":"pp.","article-title":"Studies on PZ, the pregnancy zone protein","volume":"22","author":"von Schoultz B","year":"1974","unstructured":"von Schoultz B. Studies on PZ, the pregnancy zone protein. Sweden, University of Umra 1974. 22 pp. (Dissertation.)"},{"key":"ref_2","first-page":"377","article-title":"Isolation and characterization of pregnancyassociated s2-glycoprotein (s2-PAG)","volume":"33","author":"Bohn, H.; Winckler, W.","year":"1976","unstructured":"Bohn H, Winckler W. Isolation and characterization of pregnancyassociated s2-glycoprotein (s2-PAG). Blut 1976;33:377-88.","journal-title":"Blut"},{"key":"ref_3","first-page":"189","article-title":"Biological and clinical significance of the immunosuppressive pregnancy zone protein (PZ)","volume-title":"Protides Biol Fluids Proc Colloq","volume":"24","author":"von Schoultz B; M-G, Damber; T, Stigbrand","year":"1976","unstructured":"von Schoultz B, Damber M-G, Stigbrand T. Biological and clinical significance of the immunosuppressive pregnancy zone protein (PZ). 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Detection and characterization of pregnancy proteins in the human placenta and their quantitative immunochemical determination in sera from pregnant women. Arch Gyndk 1971;210:440-57.","journal-title":"Arch Gyndk"},{"key":"ref_7","first-page":"603","volume":"13","author":"Horne, C.H.W.; McLay, A.L.C.; Tavadia, H.B.; Carmichael, I.; Mallinson, A.C.; Yeung Laiwah, A.A.C.; Thomas, M.A.; MacSween, R.N.M.","year":"1973","unstructured":"Horne CHW, McLay ALC, Tavadia HB, Carmichael I, Mallinson AC, Yeung Laiwah AAC, Thomas MA, MacSween RNM. Studies on pregnancy associated globulin. Clin Exp Immunol 1973;13:603-1 1.","journal-title":"Studies on pregnancy associated globulin. Clin Exp Immunol"},{"issue":"73-3","key":"ref_8","first-page":"17","article-title":"Quantitation of a new serum a-macroglobulin in pregnant pre-eclamptic and contraceptive steroid treated subjects","volume":"1973","author":"Stimson, W.H.","unstructured":"Stimson WH. Quantitation of a new serum a-macroglobulin in pregnant pre-eclamptic and contraceptive steroid treated subjects. IRCS Med Sci 1973;(73-3):17-1-3.","journal-title":"IRCS Med Sci"},{"key":"ref_9","first-page":"631","article-title":"Detection of pregnancy-associated a2-glycoprotein (a2-PAG), an immunosuppressive agent, in IgA-producing plasma cells and in body secretions. Clin Exp Immunol 1983; 51","author":"Horne, C.H.W.; Armstrong, S.S.; Thomson, A.W.; Thompson, W.D.","unstructured":"Horne CHW, Armstrong SS, Thomson AW, Thompson WD. Detection of pregnancy-associated a2-glycoprotein (a2-PAG), an immunosuppressive agent, in IgA-producing plasma cells and in body secretions. Clin Exp Immunol 1983;51:631-8."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1749-6632.1983.tb32861.x","article-title":"Home CHW. Pregnancy-associated OC2-glycoprotein (a2-PAG) and IgA: their parallel distribution in the human gastrointestinal tract","volume":"417","author":"Armstrong, S.S.; Brunt, P.W.; Mowat, N.A.G.; Recht, F.A.","year":"1983","unstructured":"Armstrong SS, Brunt PW, Mowat NAG, Recht FA, Home CHW. Pregnancy-associated OC2-glycoprotein (a2-PAG) and IgA: their parallel distribution in the human gastrointestinal tract. Ann NY Acad Sci 1983;417:169-81.","journal-title":"Ann NY Acad Sci"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0140-6736(75)90417-1","article-title":"Immunosuppressive effect of pregnancy-associated alpha2-macroglobulin","volume":"ii:","author":"l Stimson WH","year":"1975","unstructured":"l Stimson WH. Immunosuppressive effect of pregnancy-associated alpha2-macroglobulin. 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Disorders of the IgA system","volume-title":"Immunologic disorders in infants and children","author":"Johansson, S.G.O.; Hogman, C.F.; Killander, J.","unstructured":"Johansson SGO, Hogman CF, Killander J. Quantitative immunoglobulin determination. Acda Pathol Microbiol Immunol Scand 1968;74:519-30. \" Ammann AJ, Hong R. Disorders of the IgA system. In: Stiehm ER, Fulginiti VA, eds. Immunologic disorders in infants and children. 2nd ed. Philadelphia: WB Saunders, 1980: Requests for reprints to: Professor CHW Home, Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne, NEI 4LP, England.","edition":"2nd ed"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.39.2.195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:05:09Z","timestamp":1763744709000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.39.2.195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1986,2,1]]},"published-print":{"date-parts":[[1986,2]]}},"alternative-id":["10.1136\/jcp.39.2.195"],"URL":"https:\/\/doi.org\/10.1136\/jcp.39.2.195","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2]]}}}