{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:33:36Z","timestamp":1765074816309,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p>Bone marrow biopsies of 850 patients with chronic myeloproliferative disorders were taken at initial diagnosis; and 169 sequential biopsies over periods of one to 188 months. Three micron sections of all biopsies were evaluated semiquantitatively with reference to the proliferating cell lines, anomalies of megakaryocytes, and fibrosis or osteosclerosis. Correlations between initial histological findings, clinical, haematological, and survival data were analysed statistically. The predominant cell lines distinguished the classical entities of polycythaemia vera, primary thrombocythaemia, and chronic myeloid leukaemia and correlated with their different prognoses, while megakaryocytes characterised subgroups that were prone to fibrotic or blastic transformation. Based on the initial histological, clinical, and haematological data analysed a working classification of chronic myeloproliferative disorders was proposed that permits recognition of both typical and atypical cases of chronic myeloproliferative disorders.<\/jats:p>","DOI":"10.1136\/jcp.39.3.237","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"237-252","source":"Crossref","is-referenced-by-count":60,"title":["Working classification of chronic myeloproliferative disorders based on histological, haematological, and clinical findings."],"prefix":"10.1136","volume":"39","author":[{"given":"R","family":"Burkhardt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bartl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Frisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Kettner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Mahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,3,1]]},"reference":[{"issue":"6","key":"ref_1","first-page":"372","article-title":"Some speculations on the myeloproliferative syndromes","volume":"1951","author":"Dameshek, W.","unstructured":"Dameshek W. Some speculations on the myeloproliferative syndromes. Blood 1951:6:372-5.","journal-title":"Blood"},{"key":"ref_2","article-title":"Bone marrow biopsies revisiteda new dimension for haematologic malignancies","author":"Bartl, R.; Frisch, B.; Burkhardt, R.","year":"1985","unstructured":"Bartl R, Frisch B, Burkhardt R. Bone marrow biopsies revisiteda new dimension for haematologic malignancies. 2nd ed Basel: Karger, 1985.","edition":"2nd ed"},{"key":"ref_3","first-page":"179","article-title":"Chronic myloproliferative disorders (CMPD)","volume":"1984","author":"Burkhardt, R.; Bartl, R.; Jager, K.; etal","unstructured":"Burkhardt R, Bartl R, Jager K, etal. Chronic myloproliferative disorders (CMPD). Path Res Pract 1984:179:131-86.","journal-title":"Path Res Pract"},{"key":"ref_4","article-title":"Biopsy pathology of bone and bone marrow-biopsy pathology series","volume-title":"sFialkow PJ. Clonal development and stem cell origin of leukemias and related disorders","author":"Frisch, B.; Lewis, S.M.; Burkhardt, R.; Bartl, R.","year":"1985","unstructured":"Frisch B, Lewis SM, Burkhardt R, Bartl R. Biopsy pathology of bone and bone marrow-biopsy pathology series. London: Chapman and Hall, 1985. sFialkow PJ. Clonal development and stem cell origin of leukemias and related disorders. In: Gunz FW, Henderson ES, eds. Leukemia. New York: Grune and Stratton, 1983."},{"key":"ref_5","article-title":"Bone marrow biopsies updated-new prospects for clinical diagnostics","volume":"50","author":"Frisch, B.; Bartl, R.","year":"1984","unstructured":"Frisch B, Bartl R. Bone marrow biopsies updated-new prospects for clinical diagnostics. In: Essig A, ed. Bibl Haematol, vol 50, Basel: Karger 1984."},{"key":"ref_6","article-title":"BMPD-81 biomedical computer programs p-series. System program and statistical development","author":"Dixon, W.J.; Brown, M.B.","year":"1981","unstructured":"Dixon WJ, Brown MB. BMPD-81 biomedical computer programs p-series. System program and statistical development. Berkeley: University of California, 1981."},{"issue":"24","key":"ref_7","first-page":"1014","article-title":"Megakaryocytic alterations in thrombopoiesis","volume":"1960","author":"Harker, L.A.","unstructured":"Harker LA. Megakaryocytic alterations in thrombopoiesis. Blood 1960;24:1014-5.","journal-title":"Blood"},{"key":"ref_8","first-page":"9","article-title":"Myelofibrosis-osteomyelosclerosis syndrome-review of literature and histomorphology","volume":"16","author":"Burkhardt, R.; Bartl, R.; Beil, E.; etal","year":"1975","unstructured":"Burkhardt R, Bartl R, Beil E, etal. Myelofibrosis-osteomyelosclerosis syndrome-review of literature and histomorphology. Advances in the Biosciences 1975:16:9-56.","journal-title":"Advances in the Biosciences"},{"key":"ref_9","first-page":"389","article-title":"Chronic megakaryocytic granulocytic myelosis-CMGM. A subtype of chronic myeloid leukemia","volume":"1980","author":"Georgii, A.; Vykoupil, K.F.; Thiele, J.","unstructured":"Georgii A, Vykoupil KF, Thiele J. Chronic megakaryocytic granulocytic myelosis-CMGM. A subtype of chronic myeloid leukemia. Virchows Arch (Pathol Anat) 1980:389:253-68.","journal-title":"Virchows Arch (Pathol Anat)"},{"issue":"6","key":"ref_10","first-page":"155","article-title":"Megakaryopoiesis in chronic myeloproliferative diseases. A morphometric evaluation with special emphasis on primary thrombocythemia","volume":"1984","author":"Thiele, J.; Funke, S.; Holgado, S.; Choritz, H.; Heorgii, A.","unstructured":"Thiele J, Funke S, Holgado S, Choritz H, Heorgii A. Megakaryopoiesis in chronic myeloproliferative diseases. A morphometric evaluation with special emphasis on primary thrombocythemia. Ann Quant Cytol 1984:6:155-67.","journal-title":"Ann Quant Cytol"},{"key":"ref_11","first-page":"221","article-title":"Pathophysiological mechanisms operating in the development of myelofibrosis: role of megakaryocytes","volume":"24","author":"Castro-Malaspina, H.; Moore, M.A.S.","year":"1982","unstructured":"Castro-Malaspina H, Moore MAS. Pathophysiological mechanisms operating in the development of myelofibrosis: role of megakaryocytes. Nouv Rev Fr Hematol 1982:24:221-6.","journal-title":"Nouv Rev Fr Hematol"},{"key":"ref_12","first-page":"218","article-title":"Primary thrombocythaemia","author":"Silverstein, M.N.","year":"1983","unstructured":"Silverstein MN. Primary thrombocythaemia. In: Williams WJ, Beutler E, Ersley AJ, Lichtman MA, eds. Hematology. New York: McGraw-Hill, 1983:218-26."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.39.3.237","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:07:23Z","timestamp":1765073243000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.39.3.237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1986,3,1]]},"published-print":{"date-parts":[[1986,3]]}},"alternative-id":["10.1136\/jcp.39.3.237"],"URL":"https:\/\/doi.org\/10.1136\/jcp.39.3.237","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}