{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:25:36Z","timestamp":1764998736090,"version":"3.46.0"},"reference-count":31,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1986,5]]},"abstract":"<jats:p>The reactivity of a monoclonal antibody against human T lymphotropic retrovirus (antibody 12\/1-2, recognising the HTLV-1 p19 internal core viral protein) with benign and malignant cutaneous biopsy specimens was examined and compared with results obtained on normal skin, on various other human cells and tissues, and on immunoblotted extracts of tonsil squamous epithelium. In keeping with previous studies, 12\/1-2 labelled a proportion of the thymic epithelial stroma and the entire layer of basal cells in stratified non-keratinized and keratinized epithelium. Furthermore, antibody 12\/1-2 reacted with basal cell carcinomas and showed an essentially identical staining pattern in normal skin, cutaneous T cell lymphomas, and a range of benign dermatoses. The dot blot preparations showed that 12\/1-2 recognised an antigen associated with keratin intermediate filaments. These data indicate that antibody 12\/1-2 forms a useful marker for subsets of epithelial cells, which presumably participate in T cell education, and that a range of cutaneous disorders of widely different aetiology show no abnormalities in epithelial expression of this antigen.<\/jats:p>","DOI":"10.1136\/jcp.39.5.547","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"547-552","source":"Crossref","is-referenced-by-count":3,"title":["Reactivity of T lymphotropic retrovirus antibody (12\/1-2) in man: comparison of epidermis with other epithelial cells."],"prefix":"10.1136","volume":"39","author":[{"given":"E","family":"Ralfkiaer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Pulford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K C","family":"Gatter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G L","family":"Wantzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D Y","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF00916570","article-title":"Human T-lymphotropic retroviruses in adult T cell leukemia-lymphoma and acquired immune deficiency syndrome","volume":"4","author":"Sarin, P.S.; Gallo, R.C.","year":"1984","unstructured":"Sarin PS, Gallo RC. Human T-lymphotropic retroviruses in adult T cell leukemia-lymphoma and acquired immune deficiency syndrome. J Clin Immunol 1984;4:415-23.","journal-title":"J Clin Immunol"},{"key":"ref_2","first-page":"3618","article-title":"Human adult T-cell leukaemia virus: complete nucleotide sequence of the proviral genome integrated","volume-title":"leukaemia cell DNA. Proc Nat! Acad Sci","volume":"80","author":"Seiki, M.; Hattori, S.; Hirayama, Y.; Yoshida, M.","year":"1983","unstructured":"Seiki M, Hattori S, Hirayama Y, Yoshida M. Human adult T-cell leukaemia virus: complete nucleotide sequence of the proviral genome integrated in leukaemia cell DNA. Proc Nat! Acad Sci USA 1983;80:3618-22."},{"key":"ref_3","first-page":"101","article-title":"Chemical analysis of human T-cell leukaemia virus structural proteins","volume":"1984","author":"Oroszlan, S.; Copeland, T.D.; Kalyanaramen, V.S.; Samagadharen, M.G.; Schultz, A.M.; Gallo, R.C.","unstructured":"Oroszlan S, Copeland TD, Kalyanaramen VS, Samagadharen MG, Schultz AM, Gallo RC. Chemical analysis of human T-cell leukaemia virus structural proteins. In: Gallo RC, Essex ME, Gross L, eds. Human T-cell leukaemia\/lymphoma virus. USA: Cold Spring Harbor Laboratory, 1984:101-10.","journal-title":"USA: Cold Spring Harbor Laboratory; T-cell leukaemia\/lymphoma virus"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0042-6822(84)90170-3","article-title":"Identification of gag end env gene products ofhuman T-cell leukaemia virus (HTLV)","volume":"136","author":"Hattori, S.; Kiyokawa, T.; Imagawas, K.-I.","year":"1984","unstructured":"Hattori S, Kiyokawa T, Imagawas K-I, et al. Identification of gag end env gene products ofhuman T-cell leukaemia virus (HTLV). 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Virology 1982;122:297-305.","journal-title":"Virology"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.39.5.547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:23:22Z","timestamp":1764998602000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.39.5.547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1986,5,1]]},"published-print":{"date-parts":[[1986,5]]}},"alternative-id":["10.1136\/jcp.39.5.547"],"URL":"https:\/\/doi.org\/10.1136\/jcp.39.5.547","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1986,5]]}}}