{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:04:21Z","timestamp":1790723061199,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1986,6]]},"abstract":"<jats:p>Immunoreactive trypsin concentration and pancreatic lipase activity were measured in the sera of 33 patients with primary biliary cirrhosis. Immunoreactive trypsin was increased (above the normal range) in 16 (48%) and pancreatic lipase activity in 18 (55%) patients. Both enzymes were increased in 10 (30%) patients. Twenty four patients (73%) had an increase of either one or both enzymes. There was a significant correlation between immunoreactive trypsin and pancreatic lipase activity. This abnormality was not related to treatment with D-penicillamine, the age of the patients, the stage of the disease, or the severity of cholestasis. Thus most patients with primary biliary cirrhosis have increased pancreatic enzyme activity and immunoreactive trypsin concentration in their sera. These data are indicative of damage to the exocrine pancreas. The cause of this damage is as yet unknown.<\/jats:p>","DOI":"10.1136\/jcp.39.6.638","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"638-640","source":"Crossref","is-referenced-by-count":14,"title":["Serum immunoreactive trypsin and pancreatic lipase in primary biliary cirrhosis."],"prefix":"10.1136","volume":"39","author":[{"given":"V","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Katrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Junglee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D P","family":"Mikhailidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Dandona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1986,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0016-5085(82)80125-X","article-title":"The pancreas in primary biliary cirrhosis and primary sclerosing cholangitis","volume":"83","year":"1982","unstructured":"Epstein 0, Chapman RWG, Lake-Bakaar G, Foo AY, Rosalki SB, Sherlock S. 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J Clin Pathol 1981;34:970-1.","journal-title":"J Clin Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/clinchem\/29.11.2003","article-title":"Serum pancreatic lipase in thalassaemia major","volume":"29","author":"Junglee, D.; Katrak, A.; Hofibrand, A.V.; Dandona, P.","year":"1983","unstructured":"Junglee D, Katrak A, Hofibrand AV, Dandona P. Serum pancreatic lipase in thalassaemia major. Clin Chem 1983;29:2003-4.","journal-title":"Clin Chem"},{"key":"ref_9","first-page":"\"963","article-title":"Pancreatic exocrine function after truncal and highly selective vagotomy","volume":"34","author":"Mikhailidis, D.P.; Foo, Y.; Ramdial, L.; Kirk, R.M.; Rosalki, S.B.; Dandona, P.","year":"1983","unstructured":"Mikhailidis DP, Foo Y, Ramdial L, Kirk RM, Rosalki SB, Dandona P. Pancreatic exocrine function after truncal and highly selective vagotomy. J Clin Pathol 1983;34:963-4. '0 Mohiuddin J, Katrak A, Junglee D, Green M, Dandona P. Serum pancreatic enzymes in the elderly. Ann Clin Biochem 1984;21: 102-14. lDandona P, Junglee D, Katrak A, Fonseca V, Havard CW. Serum pancreatic enzymes increase following methylprednisolone: possible evidence of subclinical pancreatitis. Br Med J 1985;291:24.","journal-title":"J Clin Pathol; Serum pancreatic enzymes in the elderly"},{"key":"ref_10","first-page":"674","article-title":"The presentation and diagnosis of 100 patients with primary biliary cirrhosis","volume":"289","author":"Sherlock, S.; Scheuer, P.J.","year":"1973","unstructured":"Sherlock S, Scheuer PJ. The presentation and diagnosis of 100 patients with primary biliary cirrhosis. N Engi J Med 1973;289:674-8. '3Data Sheet Compendium (ABPI) 1983-84.","journal-title":"N Engi J Med; 3Data Sheet Compendium (ABPI) 1983-84"},{"key":"ref_11","author":"Baily, B.","unstructured":"Baily B, ed. London: Datapharm Publications, 1983:785."},{"issue":"1","key":"ref_12","first-page":"\"20P","article-title":"The effect of chronic administration of D-penicillamine on the rat pancreas","volume":"61","author":"Argent, B.E.; Case, R.M.; Smith, P.A.; Sunter, J.P.","year":"1977","unstructured":"Argent BE, Case RM, Smith PA, Sunter JP. The effect of chronic administration of D-penicillamine on the rat pancreas. Br J Pharmacol 1977;61:1 20P-I P. s Elias E, Redshaw M, Wood T. Diagnostic importance of changes in circulating concentrations of immunoreactive trypsin. 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