{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:45:18Z","timestamp":1774676718103,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:p>Immunohistochemical studies were performed in thirty skin biopsies from patients with Kaposi's sarcoma, who did and did not have the acquired immune deficiency syndrome (AIDS). Tumour histogenesis was rigorously tested using a battery of endothelial cell markers, which included two new monoclonal antibodies, EN4 and PAL E. These are both specific for endothelial cells and can be visualised in appropriately fixed paraffin embedded tissue. Whereas EN4 labels all endothelial cells, PAL E is negative in endothelium of lymphatic derivation. Lectin binding with Ulex europaeus agglutinin 1 (UEA-1) and the presence of factor VIII related antigen (FVIIIRA) and laminin were also examined. In nodular lesions of Kaposi's sarcoma the spindle cell areas were positive with EN4 and UEA-1, negative with PAL E, and showed focal staining for FVIIIRA and laminin. These results confirm that the tumour is of endothelial cell origin. Six patch stage lesions showed a network of angulated spaces, lined by cells that were positive with EN4 and UEA-1, negative with PAL E and anti-FVIIIRA, and showed only weak staining for laminin. This pattern was observed in both AIDS and non-AIDS related cases and strongly favours a lymphatic derivation for the tumour. This has important implications as it suggests that lymphatic endothelium may have special characteristics that lead to neoplastic transformation in patients with retrovirus infection.<\/jats:p>","DOI":"10.1136\/jcp.39.7.742","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"742-749","source":"Crossref","is-referenced-by-count":80,"title":["Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS)."],"prefix":"10.1136","volume":"39","author":[{"given":"R R","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Spaull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Spry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E W","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/1097-0142(195903\/04)12:2<289::AID-CNCR2820120213>3.0.CO;2-Z","article-title":"Kaposi's sarcoma","volume":"12","author":"Cox, F.H.; Helwig, E.B.","year":"1959","unstructured":"Cox FH, Helwig EB. Kaposi's sarcoma. Cancer 1959;12:289-98.","journal-title":"Cancer"},{"issue":"1","key":"ref_2","first-page":"87","article-title":"Kaposi's sarcoma in east African children. A report of 51 cases","volume":"100","author":"Slavin, G.; Cameron, H.M.; Forbes, C.; Morton-Mitchell, R.","year":"1970","unstructured":"Slavin G, Cameron HM, Forbes C, Morton-Mitchell R. Kaposi's sarcoma in east African children. A report of 51 cases. J Pathol 1970;100: 1 87-99.","journal-title":"J Pathol"},{"key":"ref_3","first-page":"854","article-title":"Studies in Kaposi's sarcoma","volume":"30","author":"Templeton, A.C.","year":"1972","unstructured":"Templeton AC. Studies in Kaposi's sarcoma. Cancer 1972; 30:854-67.","journal-title":"Cancer"},{"key":"ref_4","first-page":"135","article-title":"Kaposi's sarcoma and immunosuppressive therapy: an appraisal. Clin Exp Dermatol","volume":"3","author":"Gange, R.W.; Wilson Jones, E.","year":"1978","unstructured":"Gange RW, Wilson Jones E. 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Arch Dermatol 1980;116:1280-82.","journal-title":"Arch Dermatol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/path.1711460104","article-title":"An immunohistochemical study of factor VIII related antigen and Kaposi's sarcoma using polyclonal and monoclonal antibodies","volume":"146","author":"Millard, P.R.; Heryet, A.R.","year":"1985","unstructured":"Millard PR, Heryet AR. An immunohistochemical study of factor VIII related antigen and Kaposi's sarcoma using polyclonal and monoclonal antibodies. J Pathol 1985;146:31-8.","journal-title":"J Pathol"},{"issue":"1","key":"ref_8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/ajcp\/81.1.117","article-title":"Factor VIII related antigen staining by immunoperoxidase technique in smaller laboratories: a potential problem","volume":"81","author":"Wilson, A.J.","year":"1984","unstructured":"Wilson AJ. 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The importance of elastic fibres in skin lymphatics. Br J Dermatol 1983;108:561-6.","journal-title":"Br J Dermatol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/path.1711460207","article-title":"Ulex europaeus 1 -peroxidase on a marker of vascular endothelium: its application in routine histopathology","volume":"146","author":"Walker, R.A.","year":"1985","unstructured":"Walker RA. Ulex europaeus 1 -peroxidase on a marker of vascular endothelium: its application in routine histopathology. J Pathol 1985;146: 123-7.","journal-title":"J Pathol"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00000478-198310000-00007","article-title":"Use of antibasement membrane antibodies to distinguish blood vessel capillaries from lymphatic capillaries","volume":"7","author":"Barsky, S.H.; Baker, A.; Siedgal, G.P.; Togo, S.; Liotta, L.A.","year":"1983","unstructured":"Barsky SH, Baker A, Siedgal GP, Togo S, Liotta LA. Use of antibasement membrane antibodies to distinguish blood vessel capillaries from lymphatic capillaries. Am J Surg Pathol 1983;7:667-77.","journal-title":"Am J Surg Pathol"},{"key":"ref_16","first-page":"223","article-title":"The distribution of endothelial cell antigens in cutaneous tissue using methacarn and periodate lysine paraformaldehyde fixation","volume":"404","author":"Holden, C.A.; Spaull, J.; Williams, R.; Spry, C.J.F.; Russell Jones, R.; Wilson Jones, E.","year":"1984","unstructured":"Holden CA, Spaull J, Williams R, Spry CJF, Russell Jones R, Wilson Jones E. The distribution of endothelial cell antigens in cutaneous tissue using methacarn and periodate lysine paraformaldehyde fixation. J Immunol Methods (in press). 20Svanholm H, Nielsen K, Hauge P. Factor VIII-related antigen and lymphatic collecting vessels. 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Am J Pathol (in press).","journal-title":"Am J Pathol; Evidence for the origin of Kaposi's sarcoma from lymphatic endothelium"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.39.7.742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T16:54:12Z","timestamp":1758905652000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.39.7.742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1986,7,1]]},"published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1136\/jcp.39.7.742"],"URL":"https:\/\/doi.org\/10.1136\/jcp.39.7.742","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}