{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:03:15Z","timestamp":1771023795322,"version":"3.50.1"},"reference-count":9,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:p>As part of the Medical Research Council Leukaemia Trial UKALL VIII, 738 unselected children with acute lymphoblastic leukaemia (ALL) had the morphology of their marrow blast cells reviewed by a panel of three haematologists. Ninety four (13%) showed appearances classifiable as type L2 by the French American and British (FAB) cooperative group's criteria, five (0.7%) were typed L3, and the remaining 639 (86%) as L1. Disregarding the patients classified as L3, those with the L2 variant showed an inferior disease free survival to that of the remainder (p less than 0.01), and more of them failed to remit after receiving \"standard\" remission induction treatment (p less than 0.01). They included an excess of older children (p less than 0.01) with less profound marrow failure at diagnosis, and fewer of them expressed the common ALL antigen (p = 0.05). There was no association between L2 morphology and the diagnostic white cell count, sex, or the presence of a mediastinal mass. These findings confirm earlier reports that FAB L2 ALL is associated with a poor prognosis and that it occurs more commonly in older children. The high remission failure rate is a recent observation and indicates that alternative early treatment may be appropriate for such patients.<\/jats:p>","DOI":"10.1136\/jcp.39.9.998","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"998-1002","source":"Crossref","is-referenced-by-count":25,"title":["French American British (FAB) morphological classification of childhood lymphoblastic leukaemia and its clinical importance."],"prefix":"10.1136","volume":"39","author":[{"given":"J S","family":"Lilleyman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"Hann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O B","family":"Eden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1986,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2141.1976.tb03563.x","article-title":"Proposals for the classification of the acute leukaemias","volume":"33","author":"Bennett, J.M.; Catovsky, D.; Daniel, M.T.","year":"1976","unstructured":"Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the acute leukaemias. Br J Haematol 1976;33:451-8.","journal-title":"Br J Haematol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1365-2141.1981.tb02684.x","article-title":"The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations","volume":"47","author":"Bennett, J.M.; Catovsky, D.; Daniel, M.T.","year":"1981","unstructured":"Bennett JM, Catovsky D, Daniel MT, et al. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. Br J Haematol 1981;47:553-61.","journal-title":"Br J Haematol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-2141.1978.tb05820.x","article-title":"Morphological diagnosis in childhood leukaemia","volume":"40","author":"Keleti, J.; Revesz, T.; Schuler, D.","year":"1978","unstructured":"Keleti J, Revesz T, Schuler D. Morphological diagnosis in childhood leukaemia. Br J Haematol 1978;40:501-6.","journal-title":"Br J Haematol"},{"key":"ref_4","first-page":"21","article-title":"The prognostic significance of morphological features in childhood acute lymphoblastic leukaemia","volume":"1","author":"Hann, I.M.; Evans, D.I.K.; Palmer, M.K.; Morris Jones, P.; Haworth, C.","year":"1979","unstructured":"Hann IM, Evans DIK, Palmer MK, Morris Jones P, Haworth C. The prognostic significance of morphological features in childhood acute lymphoblastic leukaemia. 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Prognostic implications of blast cell morphology in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Study Group. Cancer Treatment Rep 1985;69:1211-21.","journal-title":"Cancer Treatment Rep"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1200\/JCO.1985.3.4.477","article-title":"Clinical relevance of lymphoblast biological features in children with acute lymphoblastic leukaemia","volume":"3","author":"Kalwinsky, D.K.; Roberson, P.; Dahl, G.","year":"1985","unstructured":"Kalwinsky DK, Roberson P, Dahl G, et al. Clinical relevance of lymphoblast biological features in children with acute lymphoblastic leukaemia. J Clin Oncol 1985;3:477-89.","journal-title":"J Clin Oncol"},{"issue":"1","key":"ref_9","first-page":"1","article-title":"Report to the Council by the Working Party on Leukaemia in Childhood. Improvement in treatment for children with acute lymphoblastic leukaemia","volume":"408","year":"1972","unstructured":"Report to the Council by the Working Party on Leukaemia in Childhood. Improvement in treatment for children with acute lymphoblastic leukaemia. The Medical Research Council UKALL Trials 1972-84. 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