{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:07:04Z","timestamp":1759342024581,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>Cerebrospinal fluid from 100 patients with clinically diagnosed meningitis was examined for alpha-interferon. In the laboratory four patient groups were identified: bacterial meningitis (n = 12), viral meningitis (n = 15), normal cerebrospinal fluid (n = 57) and abnormal cerebrospinal fluid (n = 16). A further 14 patients with cerebrospinal fluid shunts but no abnormality in the cerebrospinal fluid provided a control group for alpha-interferon determinations. The group with viral meningitis and the group with abnormal cerebrospinal fluid had significantly higher alpha-interferon concentrations (p less than 0.001) when compared with those of the three other groups. This assay had great predictive value in determining those patients with abnormal cerebrospinal fluid who did not have a bacterial cause of meningitis. As the groups with abnormal cerebrospinal fluid and viral meningitis had a similar spread in alpha-interferon values it is likely that both reflect viral infection of the central nervous system.<\/jats:p>","DOI":"10.1136\/jcp.40.1.83","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"83-86","source":"Crossref","is-referenced-by-count":11,"title":["Alpha-interferon responses in cerebrospinal fluid of patients with suspected meningitis."],"prefix":"10.1136","volume":"40","author":[{"given":"D O","family":"Ho-Yen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Carrington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"ref_1","first-page":"299","article-title":"Meningitis and poliomyelitis","volume":"6","author":"J, I.Nagington; D, Rubenstein","year":"1978","unstructured":"I Nagington J, Rubenstein D. Meningitis and poliomyelitis. Medicine 1978;6:299-305.","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1001\/jama.1982.03320380035025","article-title":"The clinical relevance of \"CSF viral culture\"","volume":"247","author":"Chonmaitree, T.; Menegus, M.A.; Powell, K.R.","year":"1982","unstructured":"Chonmaitree T, Menegus MA, Powell KR. The clinical relevance of \"CSF viral culture\". JAMA 1982;247:1843-7.","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF01310863","article-title":"Interferon assay in patients suspected of viral infections as a tool for rapid diagnosis","volume":"78","author":"Negreanu, J.; Shif, I.; Gotlieb-Stematsky, T.","year":"1983","unstructured":"Negreanu J, Shif I, Gotlieb-Stematsky T. Interferon assay in patients suspected of viral infections as a tool for rapid diagnosis. Arch Virol 1983;78:103-7.","journal-title":"Arch Virol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/jmv.1890150106","article-title":"How useful are serum and CSF interferon levels as a rapid diagnostic aid in virus infections?","volume":"13","author":"Flowers, D.; Scott, G.M.","year":"1985","unstructured":"Flowers D, Scott GM. How useful are serum and CSF interferon levels as a rapid diagnostic aid in virus infections? J Med Virol 1985;13:35-47.","journal-title":"J Med Virol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/jmv.1890150304","article-title":"Neutralising antibody and interferon in cerebrospinal fluids and sera of acute aseptic meningitis","volume":"15","author":"Ichimura, H.; Shimase, K.; Tamura, I.","year":"1985","unstructured":"Ichimura H, Shimase K, Tamura I, et al. Neutralising antibody and interferon in cerebrospinal fluids and sera of acute aseptic meningitis. J Med Virol 1985;15:231-7.","journal-title":"J Med Virol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1056\/NEJM196506032722203","article-title":"Circulating interferonlike viral inhibitor in patients with meningitis due to Haemophilus influenzae","volume":"272","author":"Michaelis, R.H.; Weinberger, M.M.; Ho, M.","year":"1965","unstructured":"Michaelis RH, Weinberger MM, Ho M. Circulating interferonlike viral inhibitor in patients with meningitis due to Haemophilus influenzae. New Engl J Med 1965;272:1148-52.","journal-title":"New Engl J Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1699-0463.1968.tb00499.x","article-title":"The occurrence of interferon in the cerebrospinal fluid in patients with bacterial meningitis","volume":"13","author":"Haahr, S.","year":"1968","unstructured":"Haahr S. The occurrence of interferon in the cerebrospinal fluid in patients with bacterial meningitis. Acta Pathol Microbiol Scand 1968;13:264-74.","journal-title":"Acta Pathol Microbiol Scand"},{"issue":"96","key":"ref_8","first-page":"21","article-title":"Interferon in the cerebrospinal fluid of children with central nervous system disorders","volume":"1967","author":"Larke, R.P.B.","unstructured":"Larke RPB. Interferon in the cerebrospinal fluid of children with central nervous system disorders. Can Med Assoc J 1967-96:21-32.","journal-title":"Can Med Assoc J"},{"key":"ref_9","first-page":"285","article-title":"Recovery of interferon-like substance","volume-title":"from cerebrospinal fluid. Proc Soc Exp Biol Med","volume":"117","author":"Gresser, I.; Naficy, K.","year":"1964","unstructured":"Gresser I, Naficy K. Recovery of interferon-like substance from cerebrospinal fluid. Proc Soc Exp Biol Med 1964;117:285-9."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/285446a0","article-title":"A monoclonal antibody for large-scale purification of human leukocyte interferon","volume":"285","author":"Secher, D.S.; Burke, D.C.","year":"1980","unstructured":"Secher DS,-Burke DC. A monoclonal antibody for large-scale purification of human leukocyte interferon. Nature 1980; 285:446-50.","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1128\/JCM.11.4.324-327.1980","article-title":"Evaluation of cerebrospinal fluid lactic acid levels as an aid in differential diagnosis of bacterial and viral meningitis in adults","volume":"11","author":"Lannigan, R.; Macdonald, M.A.; Marrie, T.J.; Haldane, E.V.","year":"1980","unstructured":"Lannigan R, Macdonald MA, Marrie TJ, Haldane EV. Evaluation of cerebrospinal fluid lactic acid levels as an aid in differential diagnosis of bacterial and viral meningitis in adults. J Clin Microbiol 1980;11:324-7.","journal-title":"J Clin Microbiol"},{"key":"ref_12","first-page":"989","article-title":"A major role for viruses in acute childhood encephalopathy","volume":"i:","author":"Kennedy, C.R.; Chrzanowska, K.; Robinson, R.O.; Tyrrell, D.A.J.; Valman, H.B.; Webster, A.D.B.","year":"1986","unstructured":"Kennedy CR, Chrzanowska K, Robinson RO, Tyrrell DAJ, Valman HB, Webster ADB. A major role for viruses in acute childhood encephalopathy. Lancet 1986;i:989-91.","journal-title":"Lancet"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.40.1.83","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:41:00Z","timestamp":1758789660000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.40.1.83"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1987,1,1]]},"published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1136\/jcp.40.1.83"],"URL":"https:\/\/doi.org\/10.1136\/jcp.40.1.83","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}