{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:20:23Z","timestamp":1789978823147,"version":"4.0.1"},"reference-count":12,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:p>Mast cell counts were carried out on sections of human carotid bodies from 39 subjects showing one of four stages of histological change associated with aging, and in five subjects showing different forms of histopathology in the carotid body associated with disease. There was no relation between mast cell density and age or the histological changes associated with aging of glomic tissue. The normal range of mast cell density calculated in terms of the 80% confidence limits was 18.5 to 67.5\/mm2. In three middle aged subjects with carotid bodies of normal histological appearance there was an abnormally high density of 83 to 96\/mm2. In two elderly subjects showing age changes of fibrosis and accumulation of lymphocytes there was an abnormally low density of 12\/mm2 or less. Mast cell density was not related to different types of carotid body hyperplasia. The mast cells were essentially stromal in location, usually closely applied to the walls of small glomic blood vessels, and were rarely found in intimate association with glomic chief cells. This suggests that mast cells are not directly concerned with the functions of glomic cells but does not preclude the possibility that they may have some effect on regulating glomic blood vessels and thus participate in the distribution of blood supply within the carotid body.<\/jats:p>","DOI":"10.1136\/jcp.40.1.9","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"9-12","source":"Crossref","is-referenced-by-count":13,"title":["Mast cells in the human carotid body."],"prefix":"10.1136","volume":"40","author":[{"given":"D","family":"Heath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1987,1,1]]},"reference":[{"key":"ref_1","article-title":"The pathology of the carotid body and sinus","author":"Heath, D.; Smith, P.","unstructured":"Heath D, Smith P. The pathology of the carotid body and sinus. London: Edward Arnold, 1985:23."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/path.1711470306","article-title":"Histological changes associated with ageing in the human carotid body","volume":"147","author":"Hurst, G.; Heath, D.; Smith, P.","year":"1985","unstructured":"Hurst G, Heath D, Smith P. Histological changes associated with ageing in the human carotid body. J Pathol 1985;147:181-7.","journal-title":"J Pathol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/path.1711380203","article-title":"Hyperplasia of the carotid body","volume":"138","author":"Heath, D.; Smith, P.; Jago, R.","year":"1982","unstructured":"Heath D, Smith P, Jago R. Hyperplasia of the carotid body. J Pathol 1982;138:115-27.","journal-title":"J Pathol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/path.1711370404","article-title":"Anatomical variation and quantitative histology of the normal and enlarged carotid body","volume":"137","author":"Smith, P.; Jago, R.; Heath, D.","year":"1982","unstructured":"Smith P, Jago R, Heath D. Anatomical variation and quantitative histology of the normal and enlarged carotid body. J Pathol 1982;137:287-304.","journal-title":"J Pathol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/0007-0971(86)90032-X","article-title":"The carotid bodies in coarctation of the aorta","volume":"80","author":"Heath, D.; Smith, P.; Hurst, G.","year":"1986","unstructured":"Heath D, Smith P, Hurst G. The carotid bodies in coarctation of the aorta. Br J Dis Chest 1986;80:122-30.","journal-title":"Br J Dis Chest"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2559.1986.tb02581.x","article-title":"The carotid bodies in a case of ventricular septal defect","volume":"10","author":"Smith, P.; Hurst, G.; Heath, D.; Drewe, R.","year":"1986","unstructured":"Smith P, Hurst G, Heath D, Drewe R. The carotid bodies in a case of ventricular septal defect. Histopathology 1986;10:831-40.","journal-title":"Histopathology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/path.1711420109","article-title":"Dark cell proliferation in carotid body hyperplasia","volume":"142","author":"Heath, D.; Smith, P.; Jago, R.","year":"1984","unstructured":"Heath D, Smith P, Jago R. Dark cell proliferation in carotid body hyperplasia. J Pathol 1984;142:39-49.","journal-title":"J Pathol"},{"issue":"9","key":"ref_8","first-page":"1370","article-title":"Staining of sulphated mucopolysaccharides","volume":"1961","author":"Heath, I.D.","unstructured":"Heath ID. Staining of sulphated mucopolysaccharides. Nature 1961;9:1370-1.","journal-title":"Nature"},{"issue":"3","key":"ref_9","first-page":"467","article-title":"Pulmonary mast cells in mitral stenosis","volume":"1969","author":"Heath, D.; Trueman, T.; Sukonthamarn, P.","unstructured":"Heath D, Trueman T, Sukonthamarn P. Pulmonary mast cells in mitral stenosis. Cardiovase Res 1969;3:467-71.","journal-title":"Cardiovase Res"},{"key":"ref_10","first-page":"195","article-title":"Some morphologic, histochemical and chemical observations on chemodectomas and the normal carotid body, including a study of the chromaffin reaction and possible ganglion cell elements","volume":"17","author":"Pryse-Davies, J.I.; Dawson, I.M.P.; Westbury, G.","year":"1964","unstructured":"Pryse-Davies JI, Dawson IMP, Westbury G. Some morphologic, histochemical and chemical observations on chemodectomas and the normal carotid body, including a study of the chromaffin reaction and possible ganglion cell elements. Cancer 1964;17:195-202.","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/1097-0142(196709)20:9<1473::AID-CNCR2820200914>3.0.CO;2-I","article-title":"Histology and ultrastructure of carotid body paragangliomas. Comparison with the normal gland","volume":"20","author":"Grimley, P.M.; Glenner, G.G.","year":"1967","unstructured":"Grimley PM, Glenner GG. Histology and ultrastructure of carotid body paragangliomas. Comparison with the normal gland. Cancer 1967;20:1473-88.","journal-title":"Cancer"},{"key":"ref_12","first-page":"636","article-title":"Chronic hypoxia and chemodectomas in bovines at high altitudes","volume":"100","author":"Arias-Stella, J.; Bustos, F.","year":"1976","unstructured":"Arias-Stella J, Bustos F. Chronic hypoxia and chemodectomas in bovines at high altitudes. Arch Pathol Lab Med 1976;100:636-9.","journal-title":"Arch Pathol Lab Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.40.1.9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:52:28Z","timestamp":1765695148000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.40.1.9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1987,1,1]]},"published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1136\/jcp.40.1.9"],"URL":"https:\/\/doi.org\/10.1136\/jcp.40.1.9","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}