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Eur J Cancer Clin Oncol 1987;23:277-82.","journal-title":"Eur J Cancer Clin Oncol"},{"key":"ref_17","first-page":"3982","article-title":"Flow cytometry in clinical cancer research","volume":"43","author":"Barlogie, B.; Raber, M.N.; Schumann, J.; etal","year":"1983","unstructured":"Barlogie B, Raber MN, Schumann J, etal. Flow cytometry in clinical cancer research. Cancer Res 1983;43:3982-97.","journal-title":"Cancer Res"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF02339807","article-title":"Analysis of PCP-data to determine the fraction of cells in the various phases of the cell cycle","volume":"12","author":"Baisch, H.; Gohde, W.; Linden, W.A.","year":"1975","unstructured":"Baisch H, Gohde W, Linden WA. Analysis of PCP-data to determine the fraction of cells in the various phases of the cell cycle. 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Accessibility of DNA in situ to various fluorochromes: Relationship to chromatin changes during erythroid differentiation of friend leukemia cells. Cytometry 1984;5:355-63.","journal-title":"Cytometry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0165-4608(86)90373-0","article-title":"Clustering of chromosomal breakpoints in neoplasia","volume":"19","author":"Mittelman, F.","year":"1986","unstructured":"Mittelman F. Clustering of chromosomal breakpoints in neoplasia. Cancer Genet Cytogenet 1986;19:67-71.","journal-title":"Cancer Genet Cytogenet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/hon.2900030403","article-title":"Prognostic significance of DNA-analysis by flow cytometry in nonHodgkin's lymphoma","volume":"3","author":"Roos, G.; Dige, U.; Lenner, P.; Lindh, J.; Johansson, H.","year":"1985","unstructured":"Roos G, Dige U, Lenner P, Lindh J, Johansson H. Prognostic significance of DNA-analysis by flow cytometry in nonHodgkin's lymphoma. Hematol Oncol 1985;3:233-42.","journal-title":"Hematol Oncol"},{"key":"ref_25","first-page":"1","article-title":"The effect of different human sera on the karyologic picture of HeLa cells. A contribution to the knowledge of environmental influences on cell populations","volume":"(Thesis.)","author":"Saksela, E.","year":"1962","unstructured":"Saksela E. The effect of different human sera on the karyologic picture of HeLa cells. A contribution to the knowledge of environmental influences on cell populations. Helsinki: University of Helsinki, 1962. (Thesis.) 1-73."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0165-4608(84)90113-4","article-title":"Mitotic modifications and aberrations in human cervical cancer","volume":"11","author":"Therman, E.; Buchler, D.A.; Nieminen, U.; Timonen, S.","year":"1984","unstructured":"Therman E, Buchler DA, Nieminen U, Timonen S. Mitotic modifications and aberrations in human cervical cancer. Cancer Genet Cvtogenet 1984;11:185-97.","journal-title":"Cancer Genet Cvtogenet"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0065-230X(08)60886-6","article-title":"Phenotypic and cytogenetic characteristics of human B-lymphoid cell lines and their relevance for the etiology of Burkitt's lymphoma","volume":"37","author":"Nilsson, K.; Klein, G.","year":"1982","unstructured":"Nilsson K, Klein G. Phenotypic and cytogenetic characteristics of human B-lymphoid cell lines and their relevance for the etiology of Burkitt's lymphoma. Adv Cancer Res 1982;37:319-80.","journal-title":"Adv Cancer Res"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1056\/NEJM198103193041221","article-title":"Chromosome translocations in Burkitt's lymphoma","volume":"304","author":"Miyoshi 1, Hamasaki K, Miyamoto K","year":"1981","unstructured":"Miyoshi 1, Hamasaki K, Miyamoto K, et al. 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