{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:54:55Z","timestamp":1765702495717,"version":"3.48.0"},"reference-count":21,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:p>A patient receiving long-term haemodialysis developed systemic amyloidosis, which was shown immunohistochemically to be of beta 2-microglobulin type, a previously unrecognised form of systemic amyloidosis. Histologically, the amyloid deposits were closely associated with foci of acute and granulomatous inflammation and vasculitis, although it was not clear if the amyloid deposits directly caused the inflammatory process, or if amyloid was deposited preferentially in areas of inflammation of uncertain aetiology.<\/jats:p>","DOI":"10.1136\/jcp.40.10.1247","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1247-1251","source":"Crossref","is-referenced-by-count":26,"title":["Systemic amyloidosis of beta 2-microglobulin type: a complication of long-term haemodialysis."],"prefix":"10.1136","volume":"40","author":[{"given":"J M","family":"Theaker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A E","family":"Raine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A J","family":"Rainey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Heryet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D O","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"issue":"1 1","key":"ref_1","first-page":"8","article-title":"Peripheral nerve entrapment syndromes in chronic hemodialysis patients","volume":"30","author":"Delmez, J.A.; Holtmann, B.; Sicard, G.A.; Goldberg, A.P.; Harter, H.R.","year":"1982","unstructured":"Delmez JA, Holtmann B, Sicard GA, Goldberg AP, Harter HR. Peripheral nerve entrapment syndromes in chronic hemodialysis patients. Nephron 1982;30:1 1 8-23.","journal-title":"Nephron"},{"key":"ref_2","first-page":"127","article-title":"Deposition of an amyloid-like substance as a possible complication of regular dialysis treatment. Contributions to Nephrology 1983; 36","author":"Kachel, H.G.; Altmeyer, P.; Baldamus, C.A.; Koch, K.-M.","unstructured":"Kachel HG, Altmeyer P, Baldamus CA, Koch K-M. Deposition of an amyloid-like substance as a possible complication of regular dialysis treatment. Contributions to Nephrology 1983;36:127-32."},{"key":"ref_3","first-page":"133","article-title":"Carpal tunnel syndrome: a major complication in long-term hemodialysis patients","volume":"22","author":"Schwarz, A.; Keller, E.; Seyfert, S.; Poll, W.; Molzahn, M.; Distler, A.","year":"1984","unstructured":"Schwarz A, Keller E, Seyfert S, Poll W, Molzahn M, Distler A. Carpal tunnel syndrome: a major complication in long-term hemodialysis patients. Clin Nephrol 1984;22:133-7.","journal-title":"Clin Nephrol"},{"key":"ref_4","first-page":"1029","article-title":"Amyloidosis of a possible new type in patients receiving long-term hemodialysis","volume":"109","author":"Morita, T.; Suzuki, M.; Kamimura, A.; Hirasawa, Y.","year":"1985","unstructured":"Morita T, Suzuki M, Kamimura A, Hirasawa Y. Amyloidosis of a possible new type in patients receiving long-term hemodialysis. Arch Pathol Lab Med 1985;109:1029-32.","journal-title":"Arch Pathol Lab Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1136\/bmj.293.6559.1392","article-title":"Dialysis arthropathy: amyloid or iron?","volume":"293","author":"Cary, N.R.B.; Sethi, D.; Brown, E.A.; Erhardt, C.C.; Woodrow, D.F.; Gower, P.E.","year":"1986","unstructured":"Cary NRB, Sethi D, Brown EA, Erhardt CC, Woodrow DF, Gower PE. Dialysis arthropathy: amyloid or iron? Br Med J 1986;293:1392-4.","journal-title":"Br Med J"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0006-291X(85)91948-5","article-title":"A new form of amyloid protein associated with chronic haemodialysis was identified as B2-microglobulin","volume":"129","author":"Gejyo, F.; Yamada, T.; Odani, S.","year":"1985","unstructured":"Gejyo F, Yamada T, Odani S, et al. A new form of amyloid protein associated with chronic haemodialysis was identified as B2-microglobulin. Biochem Biophys Res Commun 1985;129: 701-6.","journal-title":"Biochem Biophys Res Commun"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1172\/JCI112257","article-title":"Beta-2 microglobulin is an amyloidogenic protein in man","volume":"76","author":"Gorevic, P.D.; Casey, T.T.; Stone, W.J.; DiRaimondo, C.R.; Prelli, F.C.; Frangione, B.","year":"1985","unstructured":"Gorevic PD, Casey TT, Stone WJ, DiRaimondo CR, Prelli FC, Frangione B. Beta-2 microglobulin is an amyloidogenic protein in man. J Clin Invest 1985;76:2425-9.","journal-title":"J Clin Invest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/jcp.38.6.653","article-title":"Hepatic copper distribution in primary biliary cirrhosis shown by the scanning proton microprobe","volume":"38","author":"Vaux, D.J.T.; Watt, F.; Grime, G.W.; Takacs, J.","year":"1985","unstructured":"Vaux DJT, Watt F, Grime GW, Takacs J. Hepatic copper distribution in primary biliary cirrhosis shown by the scanning proton microprobe. J Clin Pathol 1985;38:653-8.","journal-title":"J Clin Pathol"},{"key":"ref_9","first-page":"35","article-title":"The use of monoclonal antibodies in histopathological diagnosis","volume":"12","author":"Gatter, K.C.; Falini, B.; Mason, D.Y.","year":"1984","unstructured":"Gatter KC, Falini B, Mason DY. The use of monoclonal antibodies in histopathological diagnosis. Rec Adv Histopathol 1984; 12:35-67.","journal-title":"Rec Adv Histopathol"},{"issue":"1283-92","key":"ref_10","first-page":"133","article-title":"Amyloid deposits and amyloidosis. The f-fibrilloses (Parts I and II)","volume":"302","author":"Glenner, G.G.","year":"1980","unstructured":"Glenner GG. Amyloid deposits and amyloidosis. The f-fibrilloses (Parts I and II). N Engl J Med 1980;302:1283-92; 133-43.","journal-title":"N Engl J Med"},{"key":"ref_11","first-page":"145","article-title":"Amyloidosis","volume-title":"The Oxford textbook of medicine","volume":"9","author":"Pepys, M.B.","year":"1987","unstructured":"Pepys MB. Amyloidosis. In: Weatherall DJ, Ledingham JGG, Warrell DA, eds. The Oxford textbook of medicine. 2nd Ed. London: Oxford University Press 1987;9:145-57.","edition":"2"},{"key":"ref_12","first-page":"43","article-title":"Apparition d'une amylose (AML) generalisee chez une patiente hemodialys&e (HD)","volume":"6","author":"Villeboeuf, J.; Hillion, Y.; Haas, T.; Simon, N.; Hillion, D.","year":"1985","unstructured":"Villeboeuf J, Hillion Y, Haas T, Simon N, Hillion D. Apparition d'une amylose (AML) generalisee chez une patiente hemodialys&e (HD). Nephrologie 1985;6:43.","journal-title":"Nephrologie"},{"key":"ref_13","first-page":"92","article-title":"Apparition d'une amylose (AML) generalisee au cours de l'hemodialyse (HD). A propos d'une observation","volume":"5","author":"Herve, J.P.; Cledes, J.; Bourbigot, B.","year":"1984","unstructured":"Herve JP, Cledes J, Bourbigot B, et al. Apparition d'une amylose (AML) generalisee au cours de l'hemodialyse (HD). A propos d'une observation. Nephrologie 1984;5:92-3.","journal-title":"Nephrologie"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0046-8177(86)80183-6","article-title":"Humoral amyloidosis of bone of beta-2-microglobulin origin in association with long-term hemodialysis: New type of amyloid disease","volume":"17","author":"Casey, T.T.; Stone, W.J.; DiRaimondo, C.R.","year":"1986","unstructured":"Casey TT, Stone WJ, DiRaimondo CR, et al. Humoral amyloidosis of bone of beta-2-microglobulin origin in association with long-term hemodialysis: New type of amyloid disease. Hum Pathol 1986;17:731-8.","journal-title":"Hum Pathol"},{"key":"ref_15","first-page":"795","article-title":"Haemodialysis versus CAPD: equal predisposition to amyloidosis?","volume":"i:","author":"Ballardie, F.W.; Kerr, D.N.S.; Tennent, G.; Pepys, M.B.","year":"1986","unstructured":"Ballardie FW, Kerr DNS, Tennent G, Pepys MB. Haemodialysis versus CAPD: equal predisposition to amyloidosis? Lancet 1986;i:795-6.","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1056\/NEJM198602273140920","article-title":"Serum levels of,8-2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis","volume":"314","author":"Gejyo, F.; Homma, N.; Suzuki, Y.; Arakawa, M.","year":"1986","unstructured":"Gejyo F, Homma N, Suzuki Y, Arakawa M. Serum levels of,8-2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis. N Engl J Med 1986; 314:585-6.","journal-title":"N Engl J Med"},{"key":"ref_17","first-page":"1212","article-title":"f-2-microglobulin-associated amyloidosis in chronic haemodialysis patients","volume":"i:","year":"1986","unstructured":"Chanard J, Lavaud S, Toupance 0, Melin JP, Gillery P, Revillard JP. f-2-microglobulin-associated amyloidosis in chronic haemodialysis patients. Lancet 1986;i: 1212.","journal-title":"Lancet"},{"key":"ref_18","first-page":"481","article-title":"The complete amino acid sequence of, B-2-microglobulin","volume":"12","author":"Cunningham, B.A.; Wang, J.L.; Berggard, I.; Peterson, P.A.","year":"1973","unstructured":"Cunningham BA, Wang JL, Berggard I, Peterson PA. The complete amino acid sequence of,B-2-microglobulin. Biochemistry 1973;12:481 1-22.","journal-title":"Biochemistry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1136\/jcp.30.9.868","article-title":"Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance haemodialysis","volume":"30","author":"Dunnill, M.S.; Millard, P.R.; Oliver, D.","year":"1977","unstructured":"Dunnill MS, Millard PR, Oliver D. Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance haemodialysis. J Clin Pathol 1977;30:868-77.","journal-title":"J Clin Pathol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1136\/bmj.293.6556.1186-a","article-title":"Acquired cystic disease of the kidney: serious or irrelevant?","volume":"293","author":"Rudge, C.J.","year":"1986","unstructured":"Rudge CJ. Acquired cystic disease of the kidney: serious or irrelevant? Br Med J 1986;293:1186-7.","journal-title":"Br Med J"},{"key":"ref_21","first-page":"143","article-title":"Accumulation of silicone elastomer in regular dialysis","author":"Lauhapand, T.; Osman, E.M.; Morley, A.R.; Ward, M.K.; Kerr, D.N.S.","year":"1982","unstructured":"Lauhapand T, Osman EM, Morley AR, Ward MK, Kerr DNS. Accumulation of silicone elastomer in regular dialysis. Proceedings of the European Dialysis and Transplant Association 1982;19: 143-51.","journal-title":"Proceedings of the European Dialysis and Transplant Association"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.40.10.1247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:50:14Z","timestamp":1765702214000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.40.10.1247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":21,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1987,10,1]]},"published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1136\/jcp.40.10.1247"],"URL":"https:\/\/doi.org\/10.1136\/jcp.40.10.1247","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}