{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:26:52Z","timestamp":1782124012425,"version":"3.54.5"},"reference-count":12,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:p>A monoclonal antibody, produced by peptide immunisation was used to detect the distribution of p62c\/myc by immunohistology in normal and coeliac small intestinal mucosa. The effect of gluten in four treated coeliac patients was investigated by taking serial jejunal biopsy specimens for six hours after a 10 g oral gluten challenge. There was a progressive increase in p62c\/myc staining intensity in the villus enterocytes extending to the crypts, which accompanied the classical morphological changes occurring in the mucosa.<\/jats:p>","DOI":"10.1136\/jcp.40.3.307","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"307-311","source":"Crossref","is-referenced-by-count":6,"title":["Expression of c-myc oncogene in coeliac disease."],"prefix":"10.1136","volume":"40","author":[{"given":"P J","family":"Ciclitira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Evan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D G","family":"Wight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1987,3,1]]},"reference":[{"key":"ref_1","first-page":"301","article-title":"Cellular oncogenes and retroviruses. Ann Rev Biodifferentiate into mature cells.'3 Cell loss in coeliac disease, as measured by DNA from the washings from perfused segments of small bowel, shows a sixfold increase above normal.'4 There is a concomitant chem","volume":"62","author":"Bishop, J.M.","year":"1983","unstructured":"Bishop JM. Cellular oncogenes and retroviruses. Ann Rev Biodifferentiate into mature cells.'3 Cell loss in coeliac disease, as measured by DNA from the washings from perfused segments of small bowel, shows a sixfold increase above normal.'4 There is a concomitant chem 1983;62:301-34."},{"key":"ref_2","first-page":"438","article-title":"Expression of c-myc changes during differentiation of mouse erythroleukaemic cell lines","volume":"44","author":"Lackman, A.M.; Skonltchi, A.L.","year":"1984","unstructured":"Lackman AM, Skonltchi AL. Expression of c-myc changes during differentiation of mouse erythroleukaemic cell lines. Cancer Res 1984;44:438-41.","journal-title":"Cancer Res"},{"key":"ref_3","first-page":"171","article-title":"The detection of the increase in cell production in untreated disease, due to c-myc oncogene product in testicular cancer. Br J Cancer a higher number of proliferating cells and a doubling of the rate of cell division. The c-myc gene and its product p62cImYc have been 1985; 52","author":"Sikora, K.; Evan, G.; Stewart, J.; Watson, J.V.","unstructured":"Sikora K, Evan G, Stewart J, Watson JV. The detection of the increase in cell production in untreated disease, due to c-myc oncogene product in testicular cancer. Br J Cancer a higher number of proliferating cells and a doubling of the rate of cell division. The c-myc gene and its product p62cImYc have been 1985;52: 171-6."},{"key":"ref_4","first-page":"3403","article-title":"Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit implicated in the control of cell cycle activation and differentiation. The activation or expression of p62c\/mYc, probably in combination with other oncogene products, is in part responsible for the increase antibodies reactive with the native envelope protein","volume-title":"of Dane particles. Proc Natl Acad Sci","volume":"78","author":"Lerner, R.A.; Green, N.; Alexander, H.; Lin, F.T.; Sutcliffe, J.G.; Shinnick, T.M.","year":"1981","unstructured":"Lerner RA, Green N, Alexander H, Lin FT, Sutcliffe JG, Shinnick TM. Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit implicated in the control of cell cycle activation and differentiation. The activation or expression of p62c\/mYc, probably in combination with other oncogene products, is in part responsible for the increase antibodies reactive with the native envelope protein of Dane particles. Proc Natl Acad Sci USA 1981;78:3403-7."},{"key":"ref_5","first-page":"3610","article-title":"Isolation of monoclonal antibodies specific for the human and mouse c-myc proto-oncogene products. Molecular and cellular Biology in the rate of cell proliferation, decrease in cell cycle time, and abnormal differentiation. The true nature of the regulating mechanism, whereby gluten challenge results in an increase in the rate of cell loss","volume":"5","author":"Evan, G.; Lewis, C.K.; Ramsey, G.; Bishop, J.M.","year":"1985","unstructured":"Evan G, Lewis CK, Ramsey G, Bishop JM. Isolation of monoclonal antibodies specific for the human and mouse c-myc proto-oncogene products. Molecular and cellular Biology in the rate of cell proliferation, decrease in cell cycle time, and abnormal differentiation. The true nature of the regulating mechanism, whereby gluten challenge results in an increase in the rate of cell loss, 1985;5:3610-6."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0140-6736(80)90123-3","article-title":"Clinical testing of bread made from nullisomic 6A wheats in coeliac patients","volume":"ii:","author":"Ciclitira, P.J.; Hunter, J.O.; Lennox, E.S.","year":"1980","unstructured":"Ciclitira PJ, Hunter JO, Lennox ES. Clinical testing of bread made from nullisomic 6A wheats in coeliac patients. Lancet 1980;ii:234-7.","journal-title":"Lancet"},{"key":"ref_7","first-page":"195","article-title":"Immunohistochemistry","volume-title":"of histological techniques","author":"Bancroft, D.; Cook, H.C.","year":"1984","unstructured":"Bancroft D, Cook HC. Immunohistochemistry. In: Bancroft D, Cook HC, eds. Manual of histological techniques. London: Churchill Livingstone, 1984:195-202."},{"key":"ref_8","article-title":"Epithelial cell renewal in cultured duodenal biopsies in coeliac sprue","author":"Trier, J.S.; Browning, T.H.","year":"1970","unstructured":"Trier JS, Browning TH. Epithelial cell renewal in cultured duodenal biopsies in coeliac sprue. New Engl J Med 1970;283: insulin, or steroids.'5","journal-title":"New Engl J Med"},{"key":"ref_9","first-page":"3","article-title":"The experimental analysis of changes in proliferation and morphological status in studies on the intestine","volume":"17","author":"Wright, N.A.","year":"1982","unstructured":"Wright NA. The experimental analysis of changes in proliferation and morphological status in studies on the intestine. Scand J Gastroenterol 1982;17:3-10.","journal-title":"Scand J Gastroenterol"},{"key":"ref_10","first-page":"121","article-title":"Cell distribution in the jejunal mucosa in coeliac to be determined. It is probable that the insult produced by gluten results in a number of oncogene products being over or inappropriately expressed. Overproduction or abnormal expression of p62c\/mYc disease","author":"Shiner, M.","year":"1974","unstructured":"Shiner M. Cell distribution in the jejunal mucosa in coeliac to be determined. It is probable that the insult produced by gluten results in a number of oncogene products being over or inappropriately expressed. Overproduction or abnormal expression of p62c\/mYc disease. In: Hekkens WThJM, ed. Coeliac disease. Leiden, Netherlands: Stenfert Kroese, 1974:121-35."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0140-6736(68)90354-1","article-title":"Small bowell cell loss and weight loss in the coeliac syndrome","volume":"ii:","author":"Croft, D.N.; Loehrz, C.A.; Creamer, B.","year":"1968","unstructured":"Croft DN, Loehrz CA, Creamer B. Small bowell cell loss and weight loss in the coeliac syndrome. Lancet 1968;ii:68-70.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0092-8674(83)90092-2","article-title":"Cell-specific regulation may play a part in the failure of the dividing cells in the small bowel mucosa to attain a fully differentiated of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor","volume":"35","author":"Kelly, R.; Cochran, B.H.; Stiles, C.D.; Leder, P.","year":"1983","unstructured":"Kelly R, Cochran BH, Stiles CD, Leder P. Cell-specific regulation may play a part in the failure of the dividing cells in the small bowel mucosa to attain a fully differentiated of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell 1983;35:603-10.","journal-title":"Cell"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.40.3.307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:43:08Z","timestamp":1758789788000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.40.3.307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1987,3,1]]},"published-print":{"date-parts":[[1987,3]]}},"alternative-id":["10.1136\/jcp.40.3.307"],"URL":"https:\/\/doi.org\/10.1136\/jcp.40.3.307","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}