{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T02:50:59Z","timestamp":1778122259855,"version":"3.51.4"},"reference-count":44,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:p>Eighty four colonic biopsy specimens were obtained from patients with ulcerative colitis, Crohn's disease, radiation colitis, infectious colitis, and from normal controls. Paired specimens were examined by histological and immunohistochemical methods using monoclonal antibodies to the beta chain of HLA-DR antigen. The expression of HLA-DR antigen in mucosal epithelial cells was strongly related to whether the specimens were actively inflamed: epithelial cells from 34 of 37 inflamed specimens (nu three of 42 non-inflamed specimens) were HLA-DR positive (p less than 0.0001). Epithelial cells were uniformly HLA-DR negative in specimens from normal control patients despite the presence of HLA-DR positive lymphoid cells and macrophages in the lamina propria. Epithelial cells in specimens from patients with ulcerative colitis, Crohn's disease, and radiation colitis were HLA-DR positive in 30 of 33 inflamed biopsy specimens and in only three of 25 non-inflamed specimens (p less than 0.0001). Epithelial cells were HLA-DR positive in nine of 10 biopsy specimens from patients with acute infectious colitis (p less than 0.01).<\/jats:p>","DOI":"10.1136\/jcp.40.3.312","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T04:50:46Z","timestamp":1181364646000},"page":"312-317","source":"Crossref","is-referenced-by-count":74,"title":["Class II antigen (HLA-DR) expression by intestinal epithelial cells in inflammatory diseases of colon."],"prefix":"10.1136","volume":"40","author":[{"given":"G B","family":"McDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,3,1]]},"reference":[{"key":"ref_1","article-title":"Tissue distribution and cellular expression of Ia antigens","volume-title":"Antigens 1. Mice","author":"Frelinger, J.A.","year":"1983","unstructured":"Frelinger JA. Tissue distribution and cellular expression of Ia antigens. In: Ferrone S, David CS, eds. Ia Antigens 1. Mice. Florida: CRC Press, Boca Raton, 1983."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/00007890-198411000-00001","article-title":"Ia antigens. Genes, molecules, and function","volume":"38","author":"Lafuse, W.P.; David, C.S.","year":"1984","unstructured":"Lafuse WP, David CS. Ia antigens. Genes, molecules, and function. Transplantation 1984;38:443-53.","journal-title":"Transplantation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/00007890-198409000-00019","article-title":"The detailed distribution of MHC class II antigens in normal human organs","volume":"38","author":"Daar, A.S.; Fuggle, S.V.; Fabre, J.W.; Ting, A.; Morris, P.J.","year":"1984","unstructured":"Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ. The detailed distribution of MHC class II antigens in normal human organs. Transplantation 1984;38:293-8.","journal-title":"Transplantation"},{"key":"ref_4","first-page":"19","article-title":"Genetics of the major histocompatibility complex: the final act","volume":"1","author":"Klein, J.; Figuerou, F.; Nagy, A.","year":"1983","unstructured":"Klein J, Figuerou F, Nagy A. Genetics of the major histocompatibility complex: the final act. Annual Review of Immunology 1983;1:1 19-42.","journal-title":"Annual Review of Immunology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1126\/science.6356354","article-title":"Genes of the major histocompatibility complex in mouse and man","volume":"222","author":"Steinmetz, M.; Hood, L.","year":"1983","unstructured":"Steinmetz M, Hood L. Genes of the major histocompatibility complex in mouse and man. Science 1983;222:727-33.","journal-title":"Science"},{"key":"ref_6","first-page":"111","article-title":"Aberrant expression of HLA-DR antigen in thyrocytes in Graves' disease: relevance for autoimmunity","volume":"ii:","author":"Hanafusa, T.; Pujol-Borrell, R.; Chiovato, L.; Russell, R.C.G.; Doniach, D.; Bottazzo, G.F.","year":"1983","unstructured":"Hanafusa T, Pujol-Borrell R, Chiovato L, Russell RCG, Doniach D, Bottazzo GF. Aberrant expression of HLA-DR antigen in thyrocytes in Graves' disease: relevance for autoimmunity. Lancet 1983;ii: 111-5.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/303382b0","article-title":"Graft rejection and Ia antigensparadox resolved?","volume":"303","author":"Barclay, A.N.; Mason, D.W.","year":"1983","unstructured":"Barclay AN, Mason DW. Graft rejection and Ia antigensparadox resolved? Nature 1983;303:382-3.","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1084\/jem.156.6.1780","article-title":"Regulation of murine macrophage Ia expression by a lymphokine with immune interferon activity","volume":"156","author":"Steeg, P.S.; Moore, R.N.; Johnson, H.M.; Oppenheim, J.J.","year":"1982","unstructured":"Steeg PS, Moore RN, Johnson HM, Oppenheim JJ. Regulation of murine macrophage Ia expression by a lymphokine with immune interferon activity. J Exp Med 1982;156:1780-93.","journal-title":"J Exp Med"},{"issue":"503-1","key":"ref_9","first-page":"1","article-title":"Graft-vshost reactions induce H-2 class II gene transcription in host kidney cells","volume":"20","author":"Sinclair, G.D.; Wadgymar, A.; Halloran, P.F.; Delovitch, T.L.","year":"1984","unstructured":"Sinclair GD, Wadgymar A, Halloran PF, Delovitch TL. Graft-vshost reactions induce H-2 class II gene transcription in host kidney cells. Immunogenetics 1984;20:503-1 1.","journal-title":"Immunogenetics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/310688a0","article-title":"Inducible expression of H-2 and Ia antigens on brain cells","volume":"310","author":"Wong, G.H.W.; Bartlett, P.F.; Clark-Lewis, I.; Battye, F.; Schrader, J.W.","year":"1984","unstructured":"Wong GHW, Bartlett PF, Clark-Lewis I, Battye F, Schrader JW. Inducible expression of H-2 and Ia antigens on brain cells. Nature 1984;310:688-91.","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0140-6736(84)91108-5","article-title":"Aberrant expression of HLA-DR antigens on bile duct epithelium in primary biliary cirrhosis: relevance to pathogenesis","author":"Ballardini, G.; Bianchi, F.B.; Doniach, D.","year":"1984","unstructured":"Ballardini G, Bianchi FB, Doniach D, et al. Aberrant expression of HLA-DR antigens on bile duct epithelium in primary biliary cirrhosis: relevance to pathogenesis. Lancet 1984;Ju:1009-13.","journal-title":"Lancet"},{"key":"ref_12","first-page":"1115","article-title":"Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity","volume":"ii:","author":"Bottazzo, G.F.; Pujol-Borrell, R.; Hanafusa, T.; Feldmann, M.","year":"1983","unstructured":"Bottazzo GF, Pujol-Borrell R, Hanafusa T, Feldmann M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 1983;ii: 1115-9.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/312639a0","article-title":"Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells","volume":"312","author":"Londei, M.; Lamb, JR, Bottazzo; GF, Feldmann; M.","year":"1984","unstructured":"Londei M, Lamb JR, Bottazzo GF, Feldmann M. Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. Nature 1984;312:639-41.","journal-title":"Nature"},{"key":"ref_14","first-page":"614","article-title":"Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease","volume":"53","author":"Selby, W.S.; Janossy, G.; Mason, D.Y.; Jewell, D.P.","year":"1983","unstructured":"Selby WS, Janossy G, Mason DY, Jewell DP. Expression of HLA-DR antigens by colonic epithelium in inflammatory bowel disease. 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Scand J Immunol 1980;12:77-82.","journal-title":"Scand J Immunol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/jcp.36.4.379","article-title":"Heterogeneity of HLA-DR-positive histiocytes in human intestinal lamina propria: a combined histochemical and immunohistological analysis","volume":"36","author":"Selby, W.S.; Poulter, L.W.; Hobbs, S.; Jewell, D.P.; Janossy, G.","year":"1983","unstructured":"Selby WS, Poulter LW, Hobbs S, Jewell DP, Janossy G. Heterogeneity of HLA-DR-positive histiocytes in human intestinal lamina propria: a combined histochemical and immunohistological analysis. J Clin Pathol 1983;36:379-84.","journal-title":"J Clin Pathol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0016-5085(84)90595-X","article-title":"Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease","volume":"86","author":"Surawicz, C.M.; Belic, L.","year":"1984","unstructured":"Surawicz CM, Belic L. Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease. Gastroenterology 1984;86:104-13.","journal-title":"Gastroenterology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2559.1984.tb02337.x","article-title":"An immunohistological study of benign and malignant skin tumors: epithelial aspects","volume":"8","author":"Gatter, K.C.; Pulford, K.A.F.; Vanstapel, M.J.","year":"1984","unstructured":"Gatter KC, Pulford KAF, Vanstapel MJ, et al. An immunohistological study of benign and malignant skin tumors: epithelial aspects. Histopathology 1984;8:209-27.","journal-title":"Histopathology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/BF01543018","article-title":"HLAantigen expression at the single cell level on a K562 and B cell hybrid: an analysis with monoclonal antibodies using bacterial binding assays","volume":"8","author":"Ziegler, A.; Uchanska-Ziegler, B.; Fenthen, J.; Wernet, P.","year":"1982","unstructured":"Ziegler A, Uchanska-Ziegler B, Fenthen J, Wernet P. HLAantigen expression at the single cell level on a K562 and B cell hybrid: an analysis with monoclonal antibodies using bacterial binding assays. Somatic Cell Mol Genet 1982;8:775-89.","journal-title":"Somatic Cell Mol Genet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/268248a0","article-title":"Epidermal Langerhans' cells express Ia antigens","volume":"268","author":"Klareskog, L.; Tjernlund, U.M.; Forsum, U.; Peterson, P.A.","year":"1977","unstructured":"Klareskog L, Tjernlund UM, Forsum U, Peterson PA. Epidermal Langerhans' cells express Ia antigens. Nature 1977;268:248-50.","journal-title":"Nature"},{"key":"ref_22","first-page":"207","article-title":"Expression of Ia antigen on epidermal keratinocytes is a consequence of cellular immunity","volume":"63","author":"Suitters, A.J.; Lampert, I.A.","year":"1982","unstructured":"Suitters AJ, Lampert IA. Expression of Ia antigen on epidermal keratinocytes is a consequence of cellular immunity. Br J Exp Pathol 1982;63:207-13.","journal-title":"Br J Exp Pathol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/293149a0","article-title":"Expression of Ia antigen on epidermal keratinocytes in graft-versus-host disease","volume":"293","author":"Lampert, I.A.; Suitters, A.J.; Chisholm, P.M.","year":"1981","unstructured":"Lampert IA, Suitters AJ, Chisholm PM. Expression of Ia antigen on epidermal keratinocytes in graft-versus-host disease. Nature 1981;293:149-50.","journal-title":"Nature"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/304071a0","article-title":"Lectininduced expression of DR antigen on human cultured follicular thyroid cells","volume":"304","author":"Pujol-Borrell, R.; Hanafusa, T.; Chiovato, L.; Bottazzo, G.F.","year":"1983","unstructured":"Pujol-Borrell R, Hanafusa T, Chiovato L, Bottazzo GF. Lectininduced expression of DR antigen on human cultured follicular thyroid cells. Nature 1983;304:71-3.","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/307273a0","article-title":"Astrocytes present myelin basic protein to encephalitogenic T-cell lines","volume":"307","author":"Fontana, A.; Fierz, W.; Wekerle, H.","year":"1984","unstructured":"Fontana A, Fierz W, Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 1984;307:273-6.","journal-title":"Nature"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/293150a0","article-title":"Graft-versus-host disease induces expression of Ia antigen in rat epidermal cells and gut epithelium","volume":"293","author":"Mason, D.W.; Dallman, M.; Barclay, A.N.","year":"1981","unstructured":"Mason DW, Dallman M, Barclay AN. Graft-versus-host disease induces expression of Ia antigen in rat epidermal cells and gut epithelium. Nature 1981;293:150-1.","journal-title":"Nature"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1084\/jem.156.6.1665","article-title":"Induction of Ia antigen in rat epidermal cells and gut epithelium by immunological stimuli","volume":"156","author":"Barclay, A.N.; Mason, D.W.","year":"1982","unstructured":"Barclay AN, Mason DW. Induction of Ia antigen in rat epidermal cells and gut epithelium by immunological stimuli. J Exp Med 1982;156:1665-76.","journal-title":"J Exp Med"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"447","DOI":"10.4049\/jimmunol.129.2.447","article-title":"Anomolous expression of HLA-DR antigens on human colorectal cancer cells","volume":"129","author":"Daar, A.S.; Fuggle, S.V.; Ting, A.; Fabre, J.W.","year":"1982","unstructured":"Daar AS, Fuggle SV, Ting A, Fabre JW. Anomolous expression of HLA-DR antigens on human colorectal cancer cells. J Immunol 1982;129:447-9.","journal-title":"J Immunol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1084\/jem.159.5.1532","article-title":"Murine gamma interferon activates the release of a macrophage-derived Ia-inducing factor that transfers Ia inductive capacity","volume":"159","author":"Walker, E.B.; Maini, V.; Sanchez-Lanier, M.; Warner, N.; Stewart, C.","year":"1984","unstructured":"Walker EB, Maini V, Sanchez-Lanier M, Warner N, Stewart C. Murine gamma interferon activates the release of a macrophage-derived Ia-inducing factor that transfers Ia inductive capacity. J Exp Med 1984;159:1532-47.","journal-title":"J Exp Med"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4049\/jimmunol.131.2.788","article-title":"Interferon induces enhanced expression of Ia and H-2 antigens on B lymphoid, macrophage, and myeloid cell lines","volume":"131","author":"Wong, G.H.W.; Clark-Lewis, I.; McKimm-Breschkin, J.L.; Harris, A.W.; Schrader, J.W.","year":"1983","unstructured":"Wong GHW, Clark-Lewis I, McKimm-Breschkin JL, Harris AW, Schrader JW. Interferon induces enhanced expression of Ia and H-2 antigens on B lymphoid, macrophage, and myeloid cell lines. J Immunol 1983;131:788-93.","journal-title":"J Immunol"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4049\/jimmunol.132.1.240","article-title":"Cloned human interferon-y, but not interferon-P or -a, induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines","volume":"132","author":"Kelley, V.E.; Fiers, W.; Strom, T.B.","year":"1984","unstructured":"Kelley VE, Fiers W, Strom TB. Cloned human interferon-y, but not interferon-P or -a, induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines. J Immunol 1984;132:240-5.","journal-title":"J Immunol"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1172\/JCI111243","article-title":"Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons","volume":"73","author":"Stein, M.B.; Steeg, P.S.; Johnson, H.M.; Oppenheim, J.J.","year":"1984","unstructured":"Stein MB, Steeg PS, Johnson HM, Oppenheim JJ. Regulation of human peripheral blood monocyte DR antigen expression in vitro by lymphokines and recombinant interferons. J Clin Invest 1984;73:556-65.","journal-title":"J Clin Invest"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4049\/jimmunol.131.1.315","article-title":"Induction of la and H-2 antigens on a macrophage cell line by immune interferon","volume":"131","author":"King, D.P.; Jones, P.P.","year":"1983","unstructured":"King DP, Jones PP. Induction of la and H-2 antigens on a macrophage cell line by immune interferon. J Immunol 1983;131:315-8.","journal-title":"J Immunol"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/1523-1747.ep12274691","article-title":"Interferon enhancement of HLA-DR antigen expression on epidermal Langerhans'","volume":"84","author":"Berman, B.; Duncan, M.R.; Smith, B.; Ziboh, V.A.; Palladino, M.","year":"1985","unstructured":"Berman B, Duncan MR, Smith B, Ziboh VA, Palladino M. Interferon enhancement of HLA-DR antigen expression on epidermal Langerhans' cells. J Invest Dermatol 1985;84:54-8.","journal-title":"cells. J Invest Dermatol"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.4049\/jimmunol.132.5.2244","article-title":"Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells","volume":"132","author":"Cerf-Bensussan, N.; Quaroni, A.; Kurnick, J.T.; Bhan, A.K.","year":"1984","unstructured":"Cerf-Bensussan N, Quaroni A, Kurnick JT, Bhan AK. Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells. J Immunol 1984;132:2244-52.","journal-title":"J Immunol"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00387853","article-title":"Differential tissue distribution and ontogeny of DC-1 and HLA-DR antigens","volume":"19","year":"1984","unstructured":"Natali PG, Segatto 0, Ferrone S, Tosi R, Conte G. Differential tissue distribution and ontogeny of DC-1 and HLA-DR antigens. Immunogenetics 1984;19:109-16.","journal-title":"Immunogenetics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/BF01314469","article-title":"Studies on isolated gut mucosal lymphocytes in inflammatory bowel disease","volume":"24","author":"Fiocchi, C.; Battisto, JR, Farmer; R.G.","year":"1979","unstructured":"Fiocchi C, Battisto JR, Farmer RG. Studies on isolated gut mucosal lymphocytes in inflammatory bowel disease. Dig Dis Sci 1979;24:705-17.","journal-title":"Dig Dis Sci"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1136\/gut.24.8.692","article-title":"Immunoregulatory function of human intestinal mucosa lymphoid cells: evidence for enhanced suppressor cell activity in inflammatory bowel disease","volume":"24","author":"Fiocchi, C.; Youngman, K.R.; Farmer, R.G.","year":"1983","unstructured":"Fiocchi C, Youngman KR, Farmer RG. Immunoregulatory function of human intestinal mucosa lymphoid cells: evidence for enhanced suppressor cell activity in inflammatory bowel disease. Gut 1983;24:692-701.","journal-title":"Gut"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0016-5085(82)90307-9","article-title":"Reduced suppressor cell activity in intestinal lymphocytres from patients with Crohn's disease","volume":"82","author":"Goodacre, R.L.; Bienenstock, J.","year":"1982","unstructured":"Goodacre RL, Bienenstock J. Reduced suppressor cell activity in intestinal lymphocytres from patients with Crohn's disease. Gastroenterology 1982;82:653-8.","journal-title":"Gastroenterology"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/0016-5085(81)90266-3","article-title":"Covert suppressor T cells in Crohn's disease","volume":"80","author":"Elson, C.O.; Graeff, A.S.; James, S.P.; Strober, W.","year":"1981","unstructured":"Elson CO, Graeff AS, James SP, Strober W. Covert suppressor T cells in Crohn's disease. Gastroenterology 1981;80: 1513-21.","journal-title":"Gastroenterology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/S0016-5085(84)80166-3","article-title":"Suppression of immunoglobulin synthesis by lymphocyte subpopulations in patients with Crohn's disease","volume":"86","author":"James, S.P.; Neckers, L.M.; Graeff, A.S.; Cossman, J.; Balch, C.M.; Strober, W.","year":"1984","unstructured":"James SP, Neckers LM, Graeff AS, Cossman J, Balch CM, Strober W. Suppression of immunoglobulin synthesis by lymphocyte subpopulations in patients with Crohn's disease. Gastroenterology 1984;86:1510-8.","journal-title":"Gastroenterology"},{"key":"ref_42","first-page":"321","article-title":"T cell-B cell regulation in the intestinal lamina propria","volume-title":"Crohn's disease. Gastroenterology 1985; 89","author":"Elson, C.O.; Machelski, E.; Weiserbs, D.B.","unstructured":"Elson CO, Machelski E, Weiserbs DB. T cell-B cell regulation in the intestinal lamina propria in Crohn's disease. Gastroenterology 1985;89:321-7."},{"key":"ref_43","first-page":"541","article-title":"HLA-DR antigens in lymphoid cells differ from those in myeloid cells","volume":"30","author":"Torok-Storb, B.; Nepom, G.T.; Nepom, B.S.; Hansen, J.A.","year":"1983","unstructured":"Torok-Storb B, Nepom GT, Nepom BS, Hansen JA. HLA-DR antigens in lymphoid cells differ from those in myeloid cells. Nature 1983;30S:541-3.","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/310231a0","article-title":"Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens","volume":"310","author":"Ready, A.R.; Jenkinson, E.J.; Kingston, R.; Owen, J.J.T.","year":"1984","unstructured":"Ready AR, Jenkinson EJ, Kingston R, Owen JJT. Successful transplantation across major histocompatibility barrier of deoxyguanosine-treated embryonic thymus expressing class II antigens. 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