{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:01:42Z","timestamp":1770822102153,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:p>Eight (two men, six women) cases of adult thin basement membrane syndrome were studied to clarify the clinicopathological characteristics of the disease. The average age at the time of biopsy was 40 years. All the patients had persistent microscopic haematuria, normal renal function, and normal blood pressure, with the exception of one who was hypotensive. Most of them had persistent or transient proteinuria. Renal symptoms were found in four families, although no relative had Alport's syndrome. Renal biopsy findings observed by light and immunofluorescence microscopy did not indicate any important abnormalities, but extensive diffuse thinning of the glomerular basement membrane, ranging from 153 to 213 nm, was a constant finding by electron microscopy. All the patients retained stable renal function at the time of final follow up, indicating a benign prognosis of the syndrome.<\/jats:p>","DOI":"10.1136\/jcp.40.3.318","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"318-322","source":"Crossref","is-referenced-by-count":27,"title":["Thin basement membrane syndrome in adults."],"prefix":"10.1136","volume":"40","author":[{"given":"S","family":"Abe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Amagasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Iyori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,3,1]]},"reference":[{"key":"ref_1","article-title":"Renal disease. Classification and atlas of glomerular diseases","author":"Churg, J.; Sobin, L.H.","year":"1982","unstructured":"Churg J, Sobin LH. Renal disease. Classification and atlas of glomerular diseases. Tokyo: Igaku-shoin, 1982."},{"issue":"1","key":"ref_2","first-page":"358","article-title":"Glomerular basement membrane attenuation in familial nephritis and \"benign\" hematuria","volume":"1","author":"Piel, C.F.; Biava, C.G.; Goodman, JR","year":"1982","unstructured":"Piel CF, Biava CG, Goodman JR. Glomerular basement membrane attenuation in familial nephritis and \"benign\" hematuria. J Pediatr 1982;1O1:358-65.","journal-title":"J Pediatr"},{"key":"ref_3","first-page":"1","article-title":"The glomerular basement membrane in benign familial hematuria","volume":"17","author":"Tina, L.; Jenis, E.; Jose, P.; Medani, C.; Papadopoulou, Z.; Calcagno, P.","year":"1982","unstructured":"Tina L, Jenis E, Jose P, Medani C, Papadopoulou Z, Calcagno P. 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Am J Nephrol 1985;5:103-9.","journal-title":"Am J Nephrol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/ajcp\/45.1.7","article-title":"Thickness of glomerular basement membrane","volume":"45","author":"Osawa, G.; Kimmelstiel, P.; Seiling, V.","year":"1966","unstructured":"Osawa G, Kimmelstiel P, Seiling V. Thickness of glomerular basement membrane. Am J Clin Pathol 1966;45:7-20.","journal-title":"Am J Clin Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ki.1984.13","article-title":"Isolated hematuria in children: Indications for a renal biopsy","volume":"25","author":"Trachtman, H.; Weiss, R.A.; Bennett, B.; Greifer, I.","year":"1984","unstructured":"Trachtman H, Weiss RA, Bennett B, Greifer I. Isolated hematuria in children: Indications for a renal biopsy. Kidney Int 1984;25:94-9.","journal-title":"Kidney Int"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0046-8177(83)80180-4","article-title":"Basement membrane nephropathy: a new classification for Alport's syndrome and asymptomatic hematuria based on ultrastructural findings","volume":"14","author":"Yum, M.; Bergstein, J.M.","year":"1983","unstructured":"Yum M, Bergstein JM. Basement membrane nephropathy: a new classification for Alport's syndrome and asymptomatic hematuria based on ultrastructural findings. Hum Pathol 1983;14:996-1003.","journal-title":"Hum Pathol"},{"key":"ref_11","first-page":"251","article-title":"An electron microscopic evaluation of the width of normal glomerular basement membrane in man at various ages. Anat Rec","volume":"133","author":"Bloom, P.M.; Hartmann, J.F.; Vernier, R.L.","year":"1959","unstructured":"Bloom PM, Hartmann JF, Vernier RL. An electron microscopic evaluation of the width of normal glomerular basement membrane in man at various ages. Anat Rec 1959;133:251."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.40.3.318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:43:48Z","timestamp":1758797028000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.40.3.318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1987,3,1]]},"published-print":{"date-parts":[[1987,3]]}},"alternative-id":["10.1136\/jcp.40.3.318"],"URL":"https:\/\/doi.org\/10.1136\/jcp.40.3.318","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3]]}}}