{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:43:55Z","timestamp":1765597435987,"version":"3.48.0"},"reference-count":28,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:p>Plasma concentrations of beta 2 microglobulin (B2M), the light chain of the class I major histocompatibility complex, were measured serially in 26 patients undergoing allogeneic bone marrow transplantation (BMT). The concentrations fell after conditioning treatment, and recovered when the marrow was transplanted. Bacterial infection did not influence B2M concentration, but nine of 22 episodes of acute graft versus host disease were associated with raised concentrations. Increased plasma B2M concentrations were also a feature of eight episodes of chronic graft versus host disease, and these fell after treatment. Reactivation of herpes simplex, varicella zoster, or cytomegalovirus infections were also accompanied by raised B2M concentrations. Three patients with cytomegalovirus pneumonitis had high concentrations of plasma B2M, the rise starting between five and 22 days before onset of symptoms. Although it is non-specific, serial measurement of plasma B2M in patients undergoing BMT may be clinically useful in monitoring chronic graft versus host disease.<\/jats:p>","DOI":"10.1136\/jcp.40.6.657","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"657-662","source":"Crossref","is-referenced-by-count":6,"title":["Changes in plasma beta 2 microglobulin concentrations after allogeneic bone marrow transplantation."],"prefix":"10.1136","volume":"40","author":[{"given":"D R","family":"Norfolk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E H","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Child","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,6,1]]},"reference":[{"key":"ref_1","first-page":"2123","article-title":"Kulo RT. Immunological identity of the small subunit of HLA-A antigens and beta2microglobulin and its turnover on","volume-title":"the cell membrane. Proc Nail Acad Sci","volume":"71","author":"T, Cresswell P.Springer; MJ, Strominger J.L.Turner; HM, Grey","year":"1974","unstructured":"Cresswell P. Springer T, Strominger JL. Turner MJ, Grey HM. Kulo RT. Immunological identity of the small subunit of HLA-A antigens and beta2microglobulin and its turnover on the cell membrane. Proc Nail Acad Sci USA 1974;71:2123-7."},{"key":"ref_2","first-page":"71","article-title":"Human Ir genes: structure and function. Adi'","volume":"34","author":"Gonwa, T.A.; Stobo, Peterlin B.M.; J.D.","year":"1983","unstructured":"Gonwa TA, Peterlin BM. Stobo JD. Human Ir genes: structure and function. Adi' Inmnmunol 1983:34:71-96.","journal-title":"Inmnmunol"},{"key":"ref_3","first-page":"85","article-title":"Variation in MHC antigenic profiles of tumour cells and its biological effects","volume":"60","author":"Festenstein, H.; Schmidt, W.","year":"1981","unstructured":"Festenstein H, Schmidt W. Variation in MHC antigenic profiles of tumour cells and its biological effects. IJnmunol Rer 1981;60:85-127.","journal-title":"IJnmunol Rer"},{"key":"ref_4","first-page":"1","article-title":"Expression of beta2microglobulin on hepatocytes after liver transplantation","volume":"55","author":"Nagafuchi, Y.; Hobbs, K.E.F.; Thomas, H.C.; Scheuer, P.J.","year":"1985","unstructured":"Nagafuchi Y, Hobbs KEF, Thomas HC, Scheuer PJ. Expression of beta2microglobulin on hepatocytes after liver transplantation. Lancel 1985;i:55 1-4.","journal-title":"Lancel"},{"key":"ref_5","first-page":"391","article-title":"Serum beta2microglobulin in lymphoproliferative and myeloproliferative diseases","volume":"2","author":"Child, J.A.; Kushwaha, M.R.","year":"1984","unstructured":"Child JA, Kushwaha MR. Serum beta2microglobulin in lymphoproliferative and myeloproliferative diseases. Hentwol Oncol 1984;2:391-40 1.","journal-title":"Hentwol Oncol"},{"key":"ref_6","first-page":"510","article-title":"Serum beta2microglobulin in myelomatosis: potential value in stratification and monitoring","volume":"39","author":"Norfolk, D.R.; Child, J.A.; Cooper, E.H.; Kerruish, S.; Milford Ward, A.","year":"1980","unstructured":"Norfolk DR, Child JA, Cooper EH, Kerruish S, Milford Ward A. Serum beta2microglobulin in myelomatosis: potential value in stratification and monitoring. Br J Canicer 1980;39:510-5.","journal-title":"Br J Canicer"},{"key":"ref_7","first-page":"361","article-title":"Serum beta2microglobulin in disorders of myeloid proliferation","volume-title":"Acia Haeni7aiol","volume":"69","year":"1983","unstructured":"Norfolk DR. Child JA, Roberts BE, Forbes NMA, Cooper EH. Serum beta2microglobulin in disorders of myeloid proliferation. Acia Haeni7aiol 1983;69:361-8."},{"issue":"1","key":"ref_8","first-page":"140","article-title":"Serum beta2microglobulin and C-reactive protein concentrations in viral infections","volume":"37","author":"Cooper, E.H.; Forbes, M.A.; Hambling, M.H.","year":"1984","unstructured":"Cooper EH, Forbes MA, Hambling MH. Serum beta2microglobulin and C-reactive protein concentrations in viral infections. J Clin Pathol 1984;37:1 140-3.","journal-title":"J Clin Pathol"},{"key":"ref_9","first-page":"1560","article-title":"Abnormally high concentrations of beta2microglobulin in acquired immunodeficiency syndrome","volume":"29","author":"Bhalla, R.B.; Safai, B.; Mertelsmann, R.; Schwartz, M.K.","year":"1983","unstructured":"Bhalla RB, Safai B, Mertelsmann R, Schwartz MK. Abnormally high concentrations of beta2microglobulin in acquired immunodeficiency syndrome (AIDS) patients. Clin Chem 1983;29:1560.","journal-title":"(AIDS) patients. Clin Chem"},{"key":"ref_10","first-page":"428","article-title":"Current status of bone marrow transplantation","volume-title":"Transplant Proc 1985; 17","author":"Thomas, E.D.","unstructured":"Thomas ED. Current status of bone marrow transplantation. Transplant Proc 1985;17:428-31."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000180203","article-title":"Serum beta2microglobulin in renal disease","volume":"10","author":"Wibell, L.; Evrin, P.E.; Berggard, I.","year":"1973","unstructured":"Wibell L, Evrin PE, Berggard I. Serum beta2microglobulin in renal disease. Nephron 1973;10:320-31.","journal-title":"Nephron"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1182\/blood.V62.4.873.873","article-title":"Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement","volume":"62","author":"Hale, G.; Bright, S.; Chumbley, G.","year":"1983","unstructured":"Hale G, Bright S, Chumbley G, et al. Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood 1983;62:873-82.","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1136\/jcp.37.9.1018","article-title":"Value of serum C-reactive protein measurements in the management of bone marrow transplant recipients. Part 1: early transplant period","volume":"37","author":"Walker, S.A.; Rogers, T.A.; Riches, P.G.; White, S.; Hobbs, JR","year":"1984","unstructured":"Walker SA, Rogers TA, Riches PG, White S, Hobbs JR. Value of serum C-reactive protein measurements in the management of bone marrow transplant recipients. Part 1: early transplant period. J Clin Pathol 1984;37:1018-21.","journal-title":"J Clin Pathol"},{"key":"ref_14","first-page":"257","article-title":"Plasma beta2microglobulin and fibronectin levels in beta thalassaemia","volume":"302","author":"Cooper, E.H.; Forbes, M.A.; Bowen, M.; Gabutti, V.; Piga, A.","year":"1984","unstructured":"Cooper EH, Forbes MA, Bowen M, Gabutti V, Piga A. 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Child","journal-title":"Arthritis Rheum"},{"key":"ref_19","first-page":"535","article-title":"Antibodies to beta2microglobulin in the sera of patients with systemic lupus erythematosus","volume":"33","author":"Ooi, B.S.; Ooi, Y.M.; Pesce, A.T.; Pollak, E.","year":"1977","unstructured":"Ooi BS, Ooi YM, Pesce AT, Pollak E. Antibodies to beta2microglobulin in the sera of patients with systemic lupus erythematosus. Immunol 1977;33:535-41.","journal-title":"Immunol"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1056\/NEJM197512112932404","article-title":"Beta2microglobulin and lymphocyte infiltration in Sj6gren's syndrome","volume":"293","author":"Michalski, J.P.; Daniels, T.E.; Talal, N.; Grey, H.M.","year":"1975","unstructured":"Michalski JP, Daniels TE, Talal N, Grey HM. Beta2microglobulin and lymphocyte infiltration in Sj6gren's syndrome. 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