{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:40:27Z","timestamp":1765701627402,"version":"3.48.0"},"reference-count":5,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:p>The primary and secondary antibody responses to tetanus toxoid were measured in 18 patients with primary biliary cirrhosis and compared with those in age and sex matched controls. Although the primary antibody response in the two groups was similar, the secondary IgM antibody response in primary biliary cirrhosis was significantly higher than that in control subjects. There seems to be a correlation between secondary IgM antibody titre and total serum IgM concentration, although this fails to reach significance (p = 0.069). These results show that in primary biliary cirrhosis there is a failure to switch from IgM to IgG antibody synthesis in response to foreign antigens, and this may account for the increased serum IgM concentrations that are usually found in this disease.<\/jats:p>","DOI":"10.1136\/jcp.40.6.683","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"683-686","source":"Crossref","is-referenced-by-count":1,"title":["Antibody responses to tetanus toxoid in patients with primary biliary cirrhosis."],"prefix":"10.1136","volume":"40","author":[{"given":"D","family":"Watmough","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"French","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"Triger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,6,1]]},"reference":[{"key":"ref_1","first-page":"18","article-title":"patients without immunoglobulin deficiency or with selective IgA deficiency. Clin Exp Immunol","volume":"56","year":"1984","unstructured":"patients without immunoglobulin deficiency or with selective IgA deficiency. Clin Exp Immunol 1984;56:18-21."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1136\/gut.17.11.844","article-title":"Immune response to 0X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis","volume":"17","author":"Thomas, H.C.; Holden, R.; Jones, J.V.; Peacock, D.B.","year":"1976","unstructured":"Thomas HC, Holden R, Jones JV, Peacock DB. Immune response to 0X 174 in man. 5. Primary and secondary antibody production in primary biliary cirrhosis. Gut 1976;17:844-8.","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF00929460","article-title":"Circulating activated B cells in primary biliary cirrhosis","volume":"5","author":"James, S.P.; Jones, E.A.; Hoofnagle, J.H.; Strober, W.","year":"1985","unstructured":"James SP, Jones EA, Hoofnagle JH, Strober W. Circulating activated B cells in primary biliary cirrhosis. J Clin Immunol 1985;5:254-60.","journal-title":"J Clin Immunol"},{"key":"ref_4","first-page":"297","article-title":"In vitro studies of the mechanism of increased serum IgM levels in primary biliary cirrhosis. Clin Exp Immunol","volume":"61","author":"Nouri-Aria, K.T.; Hegarty, J.E.; Neuberger, J.; Eddleston, A.L.W.F.; Williams, R.","year":"1985","unstructured":"Nouri-Aria KT, Hegarty JE, Neuberger J, Eddleston ALWF, Williams R. In vitro studies of the mechanism of increased serum IgM levels in primary biliary cirrhosis. Clin Exp Immunol 1985;61:297-304."},{"key":"ref_5","first-page":"1494","article-title":"Hyperglobulinaemia in liver disease. Requests for reprints to","volume":"i:","author":"Triger, D.R.; Wright, R.","year":"1973","unstructured":"Triger DR, Wright R. Hyperglobulinaemia in liver disease. Requests for reprints to: Dr DR Triger, Department of Lancet 1973;i: 1494-6."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.40.6.683","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:38:38Z","timestamp":1765701518000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.40.6.683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":5,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1987,6,1]]},"published-print":{"date-parts":[[1987,6]]}},"alternative-id":["10.1136\/jcp.40.6.683"],"URL":"https:\/\/doi.org\/10.1136\/jcp.40.6.683","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}