{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:24:34Z","timestamp":1763749474943,"version":"3.45.0"},"reference-count":24,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:p>Jejunal biopsy was performed on control subjects and patients with treated and untreated coeliac disease. Monoclonal antibodies to T lymphocyte surface markers were used to quantify T cell phenotypic subsets in the jejunal mucosa. The patients with untreated coeliac disease had significantly more of both suppressor\/cytotoxic and helper\/inducer T cells in the surface epithelium than either the control subjects or the treated patients. Serial jejunal biopsy specimens were taken from five treated coeliac patients for six hours after a gluten challenge. In four of these five infiltration of the surface epithelium by both T cell phenotypes, together with deterioration in the villus architecture, had occurred both within two hours of having started the challenge. This suggests that T lymphocytes may have a role in the pathogenesis of coeliac disease.<\/jats:p>","DOI":"10.1136\/jcp.40.7.741","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"741-745","source":"Crossref","is-referenced-by-count":17,"title":["Timing of infiltration of T lymphocytes induced by gluten into the small intestine in coeliac disease."],"prefix":"10.1136","volume":"40","author":[{"given":"A R","family":"Freedman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Macartney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Nelufer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Ciclitira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1987,7,1]]},"reference":[{"key":"ref_1","first-page":"425","article-title":"A study of proximal and distal intestinal structure and absorptive functions in idiopathic steatorrhoea","volume":"36","author":"JS, I.Stewart; DJ, Pollock; AV, HofTbrand; DL, Mollin; CC, Booth","year":"1967","unstructured":"I Stewart JS, Pollock DJ, HofTbrand AV, Mollin DL, Booth CC. 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