{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:51:50Z","timestamp":1790941910499,"version":"4.1.0"},"reference-count":12,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:p>Measurements of mucosal dimension, architecture, and cell counts in both lamina propria and epithelium were made on rectal biopsy specimens from 20 patients with irritable bowel syndrome (\"normal\" controls); 54 patients with ulcerative colitis, Crohn's disease, and non-specific proctitis; eight patients with small bowel Crohn's disease; and 34 in whom the rectal biopsy specimen was not diagnostic. Discriminant analysis was applied to multiple variables based on the measurements, and three variables were identified as of high predictive value. The most powerful discriminant was increased lamina propria cellularity in all forms of chronic colitis. The ratios of surface length to mucosal length and of surface epithelial height to crypt epithelial height also emerged as discriminants. Chronic inflammatory bowel disease was distinguished from normal in 95% of cases with a definite pathological diagnosis, and 85% of borderline cases were correctly classified as either normal or inflammatory when judged by the final diagnosis after follow up. This study provides a basis for automated diagnosis of rectal biopsy specimens and provides objectively validated criteria which can also be applied in routine histological diagnosis.<\/jats:p>","DOI":"10.1136\/jcp.41.1.72","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"72-79","source":"Crossref","is-referenced-by-count":41,"title":["What is colitis? Statistical approach to distinguishing clinically important inflammatory change in rectal biopsy specimens."],"prefix":"10.1136","volume":"41","author":[{"given":"D","family":"Jenkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Goodall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Drew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B B","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1988,1,1]]},"reference":[{"key":"ref_1","first-page":"715","article-title":"Numerical taxonomy and discriminant analysis applied to non-specific colitis","volume":"42","author":"Jones, J.H.; Lennard-Jones, J.E.; Morson, B.C.","year":"1973","unstructured":"Jones JH, Lennard-Jones JE, Morson BC, et al. Numerical taxonomy and discriminant analysis applied to non-specific colitis. Q J Med 1973;42:715-32.","journal-title":"Q J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0016-5085(84)90595-X","article-title":"Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease","volume":"86","author":"Surawicz, C.M.; Belic, L.","year":"1984","unstructured":"Surawicz CM, Belic L. Rectal biopsy helps to distinguish acute self-limited colitis from idiopathic inflammatory bowel disease. Gastroenterology 1984;86:104-13.","journal-title":"Gastroenterology"},{"key":"ref_3","first-page":"650","article-title":"Colonoscopic diagnosis of minimal change colitis in patients with a normal sigmnoidoscopy and normal air-contrast barium enema","volume":"ii:","author":"Elliott, P.R.; Lennard-Jones, J.E.; Bartram, C.I.","year":"1982","unstructured":"Elliott PR, Lennard-Jones JE, Bartram CI, et al. 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Ulcerative colitis in remission"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/jcp.38.7.774","article-title":"A quantitative study of immunoglobulin containing cells in the differential diagnosis of acute colitis","volume":"38","author":"JP, Van Spreeuwel; J, Lindeman; CJLM, Meijer","year":"1985","unstructured":"Van Spreeuwel JP, Lindeman J, Meijer CJLM. A quantitative study of immunoglobulin containing cells in the differential diagnosis of acute colitis. J Clin Pathol 1985;38:774-7.","journal-title":"J Clin Pathol"},{"key":"ref_10","first-page":"941","article-title":"Immunoglobulin containing cells in inflammatory bowel disease of the colon: a morphometric and immunohistochemical study","volume-title":"Gut","volume":"21","author":"Rosekrans, P.C.M.; Meijer, C.J.L.M.; Van der Wal, A.M.; Cornelisse, C.J.; Lindeman, J.","year":"1980","unstructured":"Rosekrans PCM, Meijer CJLM, Van der Wal AM, Cornelisse CJ, Lindeman J. 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