{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:45:31Z","timestamp":1776851131413,"version":"3.51.2"},"reference-count":11,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:p>Endocrine studies were made on 23 female patients aged 13 to 29 years, with delayed puberty or primary amenorrhoea and beta thalassaemia major, and 12 healthy controls, of whom six were prepubertal and six were in Tanner's stage 3-4. Each patient and control received a single intravenous dose of 100 micrograms gonadotrophin releasing hormone (GnRH), and one week later, 10 U\/kg body weight of human menopausal gonadotrophin (hMG) to stimulate ovarian function. The patients had decreased gonadotrophin reserves when compared with those of normal controls, only one of 23 patients had an intact luteinising hormone and follicle stimulating hormone response. Most of the thalassaemic patients with delayed puberty showed normal gonad response to human menopausal gonadotrophin (hMG), but three had very low responses, when compared with that of controls. The gonadal failure was even more severe in four of six patients with primary amenorrhoea. It is important to assess hypothalamic-pituitary-gonadal function in young women with beta thalassaemia major, so that those with glandular dysfunction may be started on replacement therapy.<\/jats:p>","DOI":"10.1136\/jcp.41.2.133","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"133-137","source":"Crossref","is-referenced-by-count":30,"title":["Gonadal function in patients with beta thalassaemia major."],"prefix":"10.1136","volume":"41","author":[{"given":"V","family":"De Sanctis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Vullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Katz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Wonke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Tanas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Bagni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1365-2265.1978.tb02194.x","article-title":"thyrotrophin and prolactin reserve in ft thalassaemia","volume":"9","author":"Landau, H.; Spitz, I.M.; Cividali, G.","year":"1978","unstructured":"Landau H, Spitz IM, Cividali G, et al. Gonadotrophin, thyrotrophin and prolactin reserve in ft thalassaemia. Clin Endocrinol 1978;9: 163-73.","journal-title":"Clin Endocrinol"},{"key":"ref_2","article-title":"The thalassaemia syndromes","author":"Weatherall, D.J.; Clegg, J.B.","year":"1981","unstructured":"Weatherall DJ, Clegg JB. The thalassaemia syndromes. 3rd ed. Oxford: Blackwell Scientific Publications, 1981.","edition":"3rd ed"},{"key":"ref_3","first-page":"33","article-title":"Growth at adolescence","volume":"1962","author":"Tanner, J.M.","unstructured":"Tanner JM. Growth at adolescence. Oxford: Blackwell Scientific Publications, 1962: 33."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1210\/jcem-45-4-798","article-title":"Pituitary-ovarian relationship in polycistic ovary syndrome","volume":"45","author":"Baird, D.T.; Corker, C.S.; Davidson, D.W.","year":"1977","unstructured":"Baird DT, Corker CS, Davidson DW, et al. Pituitary-ovarian relationship in polycistic ovary syndrome. J Clin Endocrinol Metab 1977;45:798-809.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_5","article-title":"Assessment of skeletal maturity and prediction of adult height (TW, method)","author":"Tanner, J.M.; Whitehouse, R.H.; Marshall, W.A.","year":"1975","unstructured":"Tanner JM, Whitehouse RH, Marshall WA, et al. Assessment of skeletal maturity and prediction of adult height (TW, method). New York: Academic Press, 1975."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/adc.41.219.454","article-title":"Standards from birth to maturity for height, weight, height velocity and weight velocity in British children","volume":"41","author":"Tanner, J.M.; Whitehouse, R.H.; Takaishi, M.","year":"1966","unstructured":"Tanner JM, Whitehouse RH, Takaishi M. Standards from birth to maturity for height, weight, height velocity and weight velocity in British children. 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J Clin Endocrinol Metab 1979,48:901-5.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_9","first-page":"497","article-title":"Endocrine abnormalities in thalassaemia major","volume":"133","author":"Costin, G.; Kogut, M.D.; Hyman, C.B.","year":"1979","unstructured":"Costin G, Kogut MD, Hyman CB, et al. Endocrine abnormalities in thalassaemia major. Am J Dis Child 1979;133:497-502.","journal-title":"Am J Dis Child"},{"key":"ref_10","first-page":"663","article-title":"Endocrine assessment of hypogonadism in patients affected by thalassaemia major. La Ric.era in Clinica e Laboratorio","volume":"10","author":"V, De Sanctis; G, Atti; M, Lucci","year":"1980","unstructured":"De Sanctis V, Atti G, Lucci M, et al. Endocrine assessment of hypogonadism in patients affected by thalassaemia major. La Ric.era in Clinica e Laboratorio 1980;10:663-7 1."},{"key":"ref_11","first-page":"48","article-title":"Clomipheneresponsive hypogonadism in sickle cell anemia","volume":"99","author":"Landefeld, C.S.; Schambelan, M.; Kaplan, S.L.","year":"1983","unstructured":"Landefeld CS, Schambelan M, Kaplan SL, et al. Clomipheneresponsive hypogonadism in sickle cell anemia. Ann Intern Med 1983;99:48 1-3.","journal-title":"Ann Intern Med"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.41.2.133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T11:15:45Z","timestamp":1765710945000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.41.2.133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1988,2,1]]},"published-print":{"date-parts":[[1988,2]]}},"alternative-id":["10.1136\/jcp.41.2.133"],"URL":"https:\/\/doi.org\/10.1136\/jcp.41.2.133","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2]]}}}