{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:13:46Z","timestamp":1765599226514,"version":"3.48.0"},"reference-count":29,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:p>Muscle biopsy specimens with a pronounced inflammatory component were evaluated for myocyte expression of class II histocompatibility antigens (HLA-DR) by immunohistochemical techniques. All 15 cases of polymyositis were positive; six cases of muscular dystrophy (two Duchenne, four facio-scapulo-humeral), and one case of acute denervation (motor neurone disease) were negative, despite having a comparably intense mononuclear infiltrate. Twelve entirely normal biopsy specimens were also negative for HLA-DR expression. Expression of this membrane glycoprotein may have a clinically important aetiological role in polymyositis, and demonstration of its presence may prove useful as a marker for this disorder in selected problematic biopsy specimens.<\/jats:p>","DOI":"10.1136\/jcp.41.4.410","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"410-414","source":"Crossref","is-referenced-by-count":25,"title":["Skeletal muscle expression of class II histocompatibility antigens (HLA-DR) in polymyositis and other muscle disorders with an inflammatory infiltrate."],"prefix":"10.1136","volume":"41","author":[{"given":"J A","family":"Zuk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"ref_1","first-page":"267","article-title":"Immunological features of polymyositis\/dermatomyositis","volume":"67","author":"Behan, W.M.H.; Behan, P.O.","year":"1985","unstructured":"Behan WMH, Behan PO. Immunological features of polymyositis\/dermatomyositis. Springer Semin Immunopathol 1985;67:267-93."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/mus.880050802","article-title":"Inflammatory myopathy: a review of etiologic and pathogenetic factors","volume":"5","author":"Whitaker, J.N.","year":"1982","unstructured":"Whitaker JN. Inflammatory myopathy: a review of etiologic and pathogenetic factors. Muscle Nerve 1982;5:573-92.","journal-title":"Muscle Nerve"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0046-8177(77)80029-4","article-title":"Immunopathology of skeletal muscle: the value of direct immunofluorescence in the diagnosis of connective tissue disease","volume":"8","author":"Oxenhandler, R.; Adelstein, E.H.; Hart, M.N.","year":"1977","unstructured":"Oxenhandler R, Adelstein EH, Hart MN. Immunopathology of skeletal muscle: the value of direct immunofluorescence in the diagnosis of connective tissue disease. 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