{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T13:30:10Z","timestamp":1762781410586,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:p>Twenty neutropenic patients with various haematological disorders were randomised prospectively to receive either intravenous amphotericin B alone or amphotericin B and oral amiloride 5 mg twice a day for treatment of confirmed or suspected fungal infection. Patients receiving amiloride had a significantly higher plasma potassium (p less than 0.01), a significantly lower urinary potassium loss (p less than 0.01), and required significantly less potassium chloride supplementation to maintain their plasma potassium within the normal range (p less than 0.001). Amiloride was well tolerated, had no clinically important side effects, and provided effective control of plasma potassium in patients treated with amphotericin B.<\/jats:p>","DOI":"10.1136\/jcp.41.5.494","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"494-497","source":"Crossref","is-referenced-by-count":25,"title":["Amiloride prevents amphotericin B related hypokalaemia in neutropenic patients."],"prefix":"10.1136","volume":"41","author":[{"given":"S R","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Galloway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J T","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0308-2261(21)00447-1","article-title":"Fungal infections in the immunocompromised host","volume":"13","author":"Hawkins, C.; Armstrong, D.","year":"1984","unstructured":"Hawkins C, Armstrong D. Fungal infections in the immunocompromised host. Clin Haematol 1984;13:599-630.","journal-title":"Clin Haematol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archinte.1971.00310140069007","article-title":"Renal tubular acidosis due to Amphotericin B nephrotoxicity","volume":"127","author":"Patterson, R.M.; Ackerman, G.L.","year":"1971","unstructured":"Patterson RM, Ackerman GL. Renal tubular acidosis due to Amphotericin B nephrotoxicity. Arch Intern Med 1971;127: 241-4.","journal-title":"Arch Intern Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0002-9343(69)90067-9","article-title":"Nephrotoxic effects of amphotericin B including renal tubular acidosis","volume":"46","author":"Douglas, J.B.; Healy, J.K.","year":"1969","unstructured":"Douglas JB, Healy JK. Nephrotoxic effects of amphotericin B including renal tubular acidosis. Am J Med 1969;46:154-62.","journal-title":"Am J Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1056\/NEJM196801182780302","article-title":"Renal tubular acidosis due to Amphotericin B","volume":"278","author":"McCurdy, N.K.; Myron, F.; Elkington, JR","year":"1968","unstructured":"McCurdy NK, Myron F, Elkington JR. Renal tubular acidosis due to Amphotericin B. N EngIJ Med 1968;278:124-31.","journal-title":"N EngIJ Med"},{"key":"ref_5","first-page":"441","volume-title":"Ion transport in human colon in vitro. Gastroenterology 1987; 93","author":"Sellin, J.H.; De Soigne, R.","unstructured":"Sellin JH, De Soigne R. Ion transport in human colon in vitro. Gastroenterology 1987;93:441-8."},{"key":"ref_6","first-page":"326","article-title":"Renal physiology revisited","volume":"11","author":"Snoble, J.K.; Varghese, L.; Sweny, P.","year":"1986","unstructured":"Snoble JK, Varghese L, Sweny P, et al. Renal physiology revisited. Amiloride. Lancet 1986;11:326-8.","journal-title":"Amiloride. Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0002-9343(82)90594-0","article-title":"Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopaenia","volume":"72","author":"Pizzo, P.A.; Robichaud, K.J.; Gill, F.A.","year":"1982","unstructured":"Pizzo PA, Robichaud KJ, Gill FA, et al. Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopaenia. Am J Med 1982;72:101-1 1.","journal-title":"Am J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0002-9343(84)90106-2","article-title":"Renal magnesium wasting associated with Amphotericin B therapy","volume":"77","author":"Barton, C.A.; Pahl, H.; Vaziri, K.D.","year":"1984","unstructured":"Barton CA, Pahl H, Vaziri KD, et al. Renal magnesium wasting associated with Amphotericin B therapy. Am J Med 1984; 77:471-544.","journal-title":"Am J Med"},{"key":"ref_9","first-page":"1395","volume":"292","author":"Davies, S.V.; Murray, J.A.; Amphotericin, B.; aminoglycoside; hypomagnesaemic tetany","year":"1986","unstructured":"Davies SV, Murray JA, Amphotericin B, aminoglycoside, and hypomagnesaemic tetany. Br Med J 1986;292:1395-6.","journal-title":"Br Med J"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1476-5381.1983.tb10711.x","article-title":"Dose dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats","volume":"80","author":"Devane, J.; Ryan, M.P.","year":"1983","unstructured":"Devane J, Ryan MP. Dose dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats. Br J Pharmacol 1983;80:421-8.","journal-title":"Br J Pharmacol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.41.5.494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:10:44Z","timestamp":1758906644000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.41.5.494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1988,5,1]]},"published-print":{"date-parts":[[1988,5]]}},"alternative-id":["10.1136\/jcp.41.5.494"],"URL":"https:\/\/doi.org\/10.1136\/jcp.41.5.494","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}