{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:03:29Z","timestamp":1788779009954,"version":"build-2803163510"},"reference-count":10,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>A study programme was set up in Wales and the West Midlands to evaluate serum immunoreactive trypsin screening for cystic fibrosis in neonates using blood spots collected for metabolic screening. By screening half the blood spots from each area, it was hoped to generate two comparable groups of fibrocystic children; those detected by screening and those not screened who would be diagnosed clinically. Over almost three years, more than 120,000 specimens were screened and 37 infants detected with cystic fibrosis. Four additional fibrocystic patients were missed on screening: two had negative immunoreactive trypsin values, of which one had meconium ileus, and two, although giving initial positive tests, were negative on follow up. Excluding infants known to be at risk, comparison of the numbers of children detected in the screened and unscreened groups showed more than a two-fold difference in favour of the screened group. There may be a large number of undiagnosed fibrocystic patients in the general population.<\/jats:p>","DOI":"10.1136\/jcp.41.7.726","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"726-729","source":"Crossref","is-referenced-by-count":27,"title":["Neonatal screening for cystic fibrosis in Wales and the West Midlands: 1. Evaluation of immunoreactive trypsin test."],"prefix":"10.1136","volume":"41","author":[{"given":"H C","family":"Ryley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Deam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Alfaham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Weller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Goodchild","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R A","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Dodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1988,7,1]]},"reference":[{"key":"ref_1","first-page":"472","article-title":"Dried blood spot screening for cystic fibrosis in the newborn","volume":"i:","author":"Crossley, JR, Elliott; RB, Smith; P.A.","year":"1979","unstructured":"Crossley JR, Elliott RB, Smith PA. Dried blood spot screening for cystic fibrosis in the newborn. Lancet 1979;i:472-4.","journal-title":"Lancet"},{"key":"ref_2","first-page":"18","article-title":"Screening for cystic fibrosis by dried blood spot trypsin assay","volume":"57","author":"Heeley, A.F.; Heeley, M.E.; King, D.N.; Kuzemko, J.A.; Walsh, M.P.","year":"1982","unstructured":"Heeley AF, Heeley ME, King DN, Kuzemko JA, Walsh MP. Screening for cystic fibrosis by dried blood spot trypsin assay. Arch Dis Child 1982;57:18-21.","journal-title":"Arch Dis Child"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0022-3476(83)80653-2","article-title":"Cystic fibrosis screening by dried blood spot trypsin assay: results in 75000 newborn infants","volume":"102","author":"Wilcken, B.; Brown, A.R.D.; Urwin, R.; Brown, D.A.","year":"1983","unstructured":"Wilcken B, Brown ARD, Urwin R, Brown DA. Cystic fibrosis screening by dried blood spot trypsin assay: results in 75000 newborn infants. 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J Inher Metab Dis 1982;5:3-5.","journal-title":"J Inher Metab Dis"},{"key":"ref_8","article-title":"Neonatal screening for CF using IRT assay in dried blood spots: a four year experience in Basse-Normandie","volume-title":"fibrosis horizons","author":"Travert, G.; Duhamel, J.F.","year":"1984","unstructured":"Travert G, Duhamel JF. Neonatal screening for CF using IRT assay in dried blood spots: a four year experience in Basse-Normandie. In: Lawson D, ed. Cystic fibrosis horizons. Chichester: J. Wiley & Sons, 1984:209."},{"key":"ref_9","article-title":"Special features of time related evolution in IRT blood levels in six of seven newborns with cystic fibrosis complicated by meconium ileus","volume-title":"Horizons","author":"Duhamel, J.F.; Travert, G.; Delmas, P.; Brouard, J.; Venezia, R.","year":"1984","unstructured":"Duhamel JF, Travert G, Delmas P, Brouard J, Venezia R. 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