{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:57:49Z","timestamp":1765601869613,"version":"3.48.0"},"reference-count":26,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>Thirty three patients with refractory myelodysplastic anaemias (RMDA) with marrow hypocellularity were reviewed to see whether they differed from those with normocellular or hypercellular marrows. The median age was 65 years with a male:female ratio of 26:7. There were 11 cases of refractory anaemia (RA), four of refractory anaemia with ringed sideroblasts (RARS), and 18 of refractory anaemia with excess of blasts (RAEB). All presented with peripheral cytopenias, mostly pancytopenia or bicytopenia dysplasia in one or more cell lineages, and a marrow biopsy specimen with less than normal numbers of nucleated cells for the age. Twenty four patients died, including 14 of the 16 who developed acute non-lymphocytic leukaemia (ANLL). The results suggest that patients with hypocellular RMDA have a similar prognosis to those with normocellular or hypercellular marrows at presentation.<\/jats:p>","DOI":"10.1136\/jcp.41.7.763","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"763-767","source":"Crossref","is-referenced-by-count":44,"title":["Refractory myelodysplastic anaemias with hypocellular bone marrow."],"prefix":"10.1136","volume":"41","author":[{"given":"Y","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Oguma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Uchino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennet, J.M.; Catovsky, D.; Daniel, M.T.","year":"1982","unstructured":"Bennet JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 1982;51:189-99.","journal-title":"Br J Haematol"},{"key":"ref_2","first-page":"99","article-title":"The myelodysplastic syndromes. Clin Lab Haematol","volume":"6","author":"Galton, D.A.G.","year":"1984","unstructured":"Galton DAG. The myelodysplastic syndromes. Clin Lab Haematol 1984;6:99-1 12."},{"key":"ref_3","first-page":"284","article-title":"Myclodysplastic syndromes (preleukemia). Semin Several factors may account for marrow hypocellularity in RMDA which usually shows cellular marrow. First, hypocellular myelodysplasia may precede hypercellular myelodysplasia.'4 Although in the present series repeat biopsy specimens were not taken in every case, this possibility is unlikely as some remained hypocellular throughout follow up and hypocellularity was found to the same degree in","author":"Koeffler, H.P.","unstructured":"Koeffler HP. Myclodysplastic syndromes (preleukemia). Semin Several factors may account for marrow hypocellularity in RMDA which usually shows cellular marrow. First, hypocellular myelodysplasia may precede hypercellular myelodysplasia.'4 Although in the present series repeat biopsy specimens were not taken in every case, this possibility is unlikely as some remained hypocellular throughout follow up and hypocellularity was found to the same degree in all Hematol 1986;23:284-99."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1136\/jcp.38.11.1201","article-title":"Myclodysplastic syndromes: pathogenesis, functional abnormalities, and clinical implications","volume":"38","author":"Jacobs, A.","year":"1985","unstructured":"Jacobs A. Myclodysplastic syndromes: pathogenesis, functional abnormalities, and clinical implications. 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Exp Hematol 1987;15:l 134--9.","journal-title":"Exp Hematol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.41.7.763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:54:55Z","timestamp":1765601695000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.41.7.763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":26,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1988,7,1]]},"published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1136\/jcp.41.7.763"],"URL":"https:\/\/doi.org\/10.1136\/jcp.41.7.763","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}