{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:54:26Z","timestamp":1763765666430,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1988,7]]},"abstract":"<jats:p>With the aid of an image quantifier, the distribution of histochemically labelled (alcian blue, pH 2.5) mucin-producing goblet cells was recorded from a gastrectomy specimen with a peptic ulcer to determine the degree of metaplasia. Of 254 measurements made, 130 were in the antrum and 124 in the fundic area. The areas occupied by cells positive for alcian blue were 7.5 (SD 9.89)% in the antral region, and 1.8 (1.84)% and 0.92 (1.15)% in the two zones representing the fundic area. The difference between the positive mucosal areas in the antrum was significantly higher (p less than 0.001) than in the fundic area. The positively stained area found along the lesser curvature was 7.76 (12.0)% while along the greater curvature, it was 2.17 (3.02)% (p less than 0.001). This method will be useful for future studies of the extent and topographical distribution of intestinal metaplasia among populations with disparate incidences of gastric carcinoma because it permits comparison of different areas of intestinal metaplasia in mucous gastric zones.<\/jats:p>","DOI":"10.1136\/jcp.41.7.799","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"799-801","source":"Crossref","is-referenced-by-count":7,"title":["Method to quantitate intestinal metaplasia of stomach by image analysis."],"prefix":"10.1136","volume":"41","author":[{"given":"C A","family":"Rubio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Porwit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Rodensj\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,7,1]]},"reference":[{"key":"ref_1","first-page":"93","article-title":"and early gastric cancer","volume-title":"Precursors ofgastric cancer","author":"Elster, K.; Stolte, M.; Carson, W.; Metaplasia, Eidt H.; dysplasia","year":"1984","unstructured":"Elster K, Stolte M, Carson W, Eidt H. Metaplasia, dysplasia, and early gastric cancer. In: Si-Chun Ming, ed. Precursors ofgastric cancer. New York: Praeger Publications, 1984:93-1 01."},{"key":"ref_2","first-page":"1319","article-title":"Incomplete sulphomucin secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres","volume-title":"Gut","volume":"26","author":"Filipe, M.I.; Potet, F.; Bogomoletz, W.V.","year":"1985","unstructured":"Filipe MI, Potet F, Bogomoletz WV, et al. Incomplete sulphomucin secreting intestinal metaplasia for gastric cancer. Preliminary data from a prospective study from three centres. Gut 1985;26:1319-26."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0344-0338(79)80047-3","article-title":"Loss of differentiation in intestinal metaplasia in cancerous stomachs. A comparative morphologic study","volume":"164","author":"Heilmann, K.L.; Hopker, W.W.","year":"1979","unstructured":"Heilmann KL, Hopker WW. Loss of differentiation in intestinal metaplasia in cancerous stomachs. A comparative morphologic study. Path Res Pract 1979;164:249-58.","journal-title":"Path Res Pract"},{"key":"ref_4","first-page":"179","article-title":"Significance of intestinal metaplasia as a precancerous condition of the stomach","volume-title":"Precursors of gastric cancer","author":"Hirota, T.; Okada, T.; Itabashi, M.","year":"1984","unstructured":"Hirota T, Okada T, Itabashi M, et al. Significance of intestinal metaplasia as a precancerous condition of the stomach. In: Si-Chun Ming, ed. Precursors of gastric cancer. New York: Praeger Publications, 1984:179-93."},{"key":"ref_5","first-page":"179","article-title":"Chronic gastritis in Japanese without reference to high incidence of gastric carcinoma","volume":"47","author":"Imai, T.; Kubo, T.; Watanabe, H.","year":"1971","unstructured":"Imai T, Kubo T, Watanabe H. Chronic gastritis in Japanese without reference to high incidence of gastric carcinoma. 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Histopathology 1980;4:271-9.","journal-title":"Histopathology"},{"issue":"231 -40","key":"ref_8","article-title":"Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation of complete and incomplete types of intestinal metaplasia to minute gastric carcinomas","volume":"65","author":"Matsukura, N.; Suzuki, K.; Kawachi, T.","year":"1980","unstructured":"Matsukura N, Suzuki K, Kawachi T, et al. Distribution of marker enzymes and mucin in intestinal metaplasia in human stomach and relation of complete and incomplete types of intestinal metaplasia to minute gastric carcinomas. JNCI 1980;65:231 -40.","journal-title":"JNCI"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/1097-0142(196709)20:9<1418::AID-CNCR2820200908>3.0.CO;2-Z","article-title":"Intestinal metaplasia and histogenesis of carcinoma in human stomach. Light and electron microscopic study","volume":"20","author":"Ming, S.C.; Goldman, H.; Freiman, D.G.","year":"1967","unstructured":"Ming SC, Goldman H, Freiman DG. Intestinal metaplasia and histogenesis of carcinoma in human stomach. Light and electron microscopic study. Cancer 1967;20:1418-29.","journal-title":"Cancer"},{"key":"ref_10","first-page":"435","article-title":"Intestinal metaplasia of the stomach. I: quantitative analysis in gastric peptic ulcer and in incipient adenocarcinoma in Japanese subjects","volume":"5","author":"Rubio, C.A.; Kato, Y.; Sugano, H.; Kitagawa, T.","year":"1985","unstructured":"Rubio CA, Kato Y, Sugano H, Kitagawa T. Intestinal metaplasia of the stomach. I: quantitative analysis in gastric peptic ulcer and in incipient adenocarcinoma in Japanese subjects. Anticancer Res 1985;5:435-40.","journal-title":"Anticancer Res"},{"key":"ref_11","first-page":"467","article-title":"Intestinal metaplasia of the stomach in Swedish and Japanese patients without ulcers or carcinoma","volume":"78","author":"Rubio, C.A.; Kato, Y.; Sugano, H.; Kitagawa, T.","year":"1987","unstructured":"Rubio CA, Kato Y, Sugano H, Kitagawa T. Intestinal metaplasia of the stomach in Swedish and Japanese patients without ulcers or carcinoma. Jpn J Cancer Res (Gann) 1987;78:467-72.","journal-title":"Jpn J Cancer Res (Gann)"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0046-8177(86)80082-X","article-title":"Intestinal metaplasia and its variants in the gastric mucosa of Portuguese subjects: A comparative analysis of biopsy and gastrectomy material","volume":"217","author":"Silva, S.; Filipe, M.I.","year":"1986","unstructured":"Silva S, Filipe MI. Intestinal metaplasia and its variants in the gastric mucosa of Portuguese subjects: A comparative analysis of biopsy and gastrectomy material. Hum Pathol 1986;217: 988-95.","journal-title":"Hum Pathol"},{"key":"ref_13","first-page":"217","article-title":"Intestinal metaplasia with colonic-type sulphomucins in the gastric mucosa; its association with gastric carcinoma","volume":"88","author":"Sipponen, P.; Seppala, K.; Varis, K.","year":"1980","unstructured":"Sipponen P, Seppala K, Varis K. Intestinal metaplasia with colonic-type sulphomucins in the gastric mucosa; its association with gastric carcinoma. Acta Pathol Microbiol Scand 1980;88:217-24.","journal-title":"Acta Pathol Microbiol Scand"},{"issue":"41","key":"ref_14","first-page":"627","article-title":"Intestinal metaplasia of the gastric mucosa","volume":"1968","author":"Stemmermann, G.N.; Hayashi, T.","unstructured":"Stemmermann GN, Hayashi T. Intestinal metaplasia of the gastric mucosa. 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Analyt Quant Cytol Histol 1988."},{"key":"ref_17","first-page":"01","article-title":"This study was supported by grants from the Requests for reprints to: Dr C A Rubio, Department of Karolinska","volume":"104","unstructured":"This study was supported by grants from the Requests for reprints to: Dr C A Rubio, Department of Karolinska Institute and the Cancer Society, Stock-Pathology, Karolinska Sjukhuset, S-104 01 Stockholm, holm.","journal-title":"Institute and the Cancer Society, Stock-Pathology, Karolinska Sjukhuset"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.41.7.799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:06:07Z","timestamp":1758819967000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.41.7.799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7]]},"references-count":17,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1988,7,1]]},"published-print":{"date-parts":[[1988,7]]}},"alternative-id":["10.1136\/jcp.41.7.799"],"URL":"https:\/\/doi.org\/10.1136\/jcp.41.7.799","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1988,7]]}}}