{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:59:54Z","timestamp":1765709994224,"version":"3.48.0"},"reference-count":8,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:p>Over eight years, eight cases of childhood myeloproliferative disease were recognised in the northern region of England (population 3.1 million). Five were classic chronic myeloid leukaemia (CML) and the three others, forms of myeloproliferative disease. No case of juvenile CML was recognised. With the exception of CML, \"adult\" type myeloproliferative disease of children is underrepresented in the literature and its natural history remains unknown.<\/jats:p>","DOI":"10.1136\/jcp.41.8.883","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"883-885","source":"Crossref","is-referenced-by-count":4,"title":["Myeloproliferative disease in children: a demographic study."],"prefix":"10.1136","volume":"41","author":[{"given":"M M","family":"Reid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P W","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Kernahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1988,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1365-2141.1964.tb00732.x","article-title":"Granulocytic leukaemia in childhood","volume":"10","author":"Hardisty, R.M.; Speed, D.E.; Till, M.","year":"1964","unstructured":"Hardisty RM, Speed DE, Till M. Granulocytic leukaemia in childhood. Br J Haematol 1964;10:551-66.","journal-title":"Br J Haematol"},{"key":"ref_2","first-page":"183","article-title":"Persistent Epstein-Barr virus infection associated with monosomy 7 or chromosome 3 abnormality in childhood myeloproliferative disorders. Br J children and young people remains unclear, with the exception of classic and juvenile CML. For example, does essential thrombocythaemia behave","volume-title":"the same way as in elderly patients? The single biggest series of Haematol 1985","volume":"60","author":"Stollman, B.; Havers, Fonatsch C.; W.","unstructured":"Stollman B, Fonatsch C. Havers W. Persistent Epstein-Barr virus infection associated with monosomy 7 or chromosome 3 abnormality in childhood myeloproliferative disorders. Br J children and young people remains unclear, with the exception of classic and juvenile CML. For example, does essential thrombocythaemia behave in the same way as in elderly patients? The single biggest series of Haematol 1985;60: 183-6."},{"key":"ref_3","first-page":"483","article-title":"ct al. A myeloproliferative disease in two infants associated with eosinophilia and chromosome t (1; 5) translocation","volume":"66","author":"Darbyshire, P.J.; Shortland, D.; Swansbury, G.J.","year":"1987","unstructured":"Darbyshire PJ, Shortland D, Swansbury GJ. ct al. A myeloproliferative disease in two infants associated with eosinophilia and chromosome t (1;5) translocation. Br J Haematol 1987;66:483-6. young patients with this disorder comes from the Mayo Clinic,\" the youngest ofwhich was aged 15. The stability and lack of clinical problems in the Mayo Clinic series suggests a course of masterly inaction, at","journal-title":"Br J Haematol; young patients with this disorder comes from the Mayo Clinic,\" the youngest ofwhich was aged 15. The stability and lack of clinical problems in the Mayo Clinic series suggests a course of masterly inaction"},{"key":"ref_4","article-title":"Pathology and morphology of chronic leukemias and related disorders","volume-title":"Neoplastic diseases of the blood","author":"Skarin, A.T.","year":"1985","unstructured":"Skarin AT. Pathology and morphology of chronic leukemias and related disorders. In: Wiernik PH, Canellos GP, et al, eds. Neoplastic diseases of the blood. New York: Churchill least initially, but this recommendation is based on small numbers. Although death has usually rapidly followed diagnosis of myelofibrosis in children, this is not always the case.'2 The theoretical risk of Livingstone, 1985."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/bjc.1980.221","article-title":"Incidence of malignant disease in childhood: a 24 year review of the Manchester Children's Tumour Registry data","volume":"42","author":"Birch, J.M.; Marsden, H.B.; Swindell, R.","year":"1980","unstructured":"Birch JM, Marsden HB, Swindell R. Incidence of malignant disease in childhood: a 24 year review of the Manchester Children's Tumour Registry data. Br J Cancer 1980;42:215-23.","journal-title":"Br J Cancer"},{"key":"ref_6","first-page":"incidence","article-title":"The Northern region children's malignant disease registry 1968-82","author":"Craft, A.W.; Amineddine, H.A.; Scott, J.E.S.; Wagget, J.","unstructured":"Craft AW, Amineddine HA, Scott JES, Wagget J. The Northern region children's malignant disease registry 1968-82: incidence"},{"key":"ref_7","first-page":"578","volume-title":"Primary thrombocythemia in the young patient. Mayo Clin Proc 1978","volume":"53","author":"Hoagland, H.C.; Silverstein, M.N.","unstructured":"Hoagland HC, Silverstein MN. Primary thrombocythemia in the young patient. Mayo Clin Proc 1978;53:578-80."},{"key":"ref_8","first-page":"861","article-title":"Myelofibrosismyeloid metaplasia in childhood","volume":"55","author":"Boxer, L.A.; Camitta, B.M.; Berenberg, W.; Fanning, J.P.","year":"1975","unstructured":"Boxer LA, Camitta BM, Berenberg W, Fanning JP. Myelofibrosismyeloid metaplasia in childhood. Pediatrics 1975;55:861-5.","journal-title":"Pediatrics"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.41.8.883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:57:32Z","timestamp":1765709852000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.41.8.883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,8]]},"references-count":8,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1988,8,1]]},"published-print":{"date-parts":[[1988,8]]}},"alternative-id":["10.1136\/jcp.41.8.883"],"URL":"https:\/\/doi.org\/10.1136\/jcp.41.8.883","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1988,8]]}}}