{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T03:01:39Z","timestamp":1764990099218,"version":"3.46.0"},"reference-count":5,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:p>The expression of immunoreactive alpha interferon was examined in 78 liver biopsy specimens using an indirect immunoperoxidase technique. Biopsy specimens included cases of acute viral hepatitis, chronic active hepatitis, primary biliary cirrhosis, alcoholic hepatitis, large bile duct obstruction and normal liver. Kupffer cells were positive for alpha interferon in all cases. Hepatocytes were negative for alpha interferon in normal liver but in acute viral hepatitis were positive in perivenular and necrotic areas. Hepatocytes were positive in periportal areas, associated with piecemeal necrosis, in chronic active hepatitis and primary biliary cirrhosis, and were positive in perivenular areas in alcoholic hepatitis and large bile duct obstruction. The unexpected finding of alpha interferon in hepatocytes in non-viral liver disease indicates that the presence of this substance in liver cells cannot be taken as a specific marker of viral infection.<\/jats:p>","DOI":"10.1136\/jcp.42.10.1065","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1065-1069","source":"Crossref","is-referenced-by-count":9,"title":["Immunolocalization of alpha interferon in liver disease."],"prefix":"10.1136","volume":"42","author":[{"given":"C G","family":"Sutherland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"al-Badri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Howatson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Farquharson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Foulis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/hep.1840060105","article-title":"Expression of B2 microglobulin on hepatocytes in acute and chronic type B hepatitis","volume":"6","author":"Nagafuchi, Y.; Scheuer, P.J.","year":"1986","unstructured":"Nagafuchi Y, Scheuer PJ. Expression of B2 microglobulin on hepatocytes in acute and chronic type B hepatitis. Hepatology 1986;6:20-3.","journal-title":"Hepatology"},{"key":"ref_2","article-title":"A comparison of the neutralising properties of monoclonal and polyclonal antibodies to human interferon alpha","author":"Exley, T.; Parti, S.; Barwick, S.; Meager, A.","year":"1984","unstructured":"Exley T, Parti S, Barwick S, Meager A. A comparison of the neutralising properties of monoclonal and polyclonal antibodies to human interferon alpha. J Gen Virol 1984; damage. Our finding of IFN-a, mainly in perivenular 65:2277-80. areas and associated with bridging necrosis in acute viral hepatitis and in periportal zones and areas of lobular inflammation in chronic active hepatitis, is","journal-title":"J Gen Virol; damage. Our finding of IFN-a, mainly in perivenular 65: 2277-80. areas and associated with bridging necrosis in acute viral hepatitis and in periportal zones and areas of lobular inflammation in chronic active hepatitis"},{"key":"ref_3","first-page":"105","article-title":"Antibodies against interferons: characterisation of interferons and immunoassays","volume-title":"interferons-a practical approach","author":"Meager, A.","year":"1987","unstructured":"Meager A. Antibodies against interferons: characterisation of interferons and immunoassays. In: Clemens MJ, Morris AG, Gearing AJH, eds. Lymphokines and interferons-a practical approach. Oxford: IRL Press, 1987:105-27."},{"key":"ref_4","first-page":"957","article-title":"Cellular localisation of alpha-interferon in Using the techniques described here, we can only hepatitis B virus-infected liver tissue. Hepatology 1986; 6: speculate as to whether hepatocytes actually synthesise IFN-a or are engaged in its uptake from surrounding cells. Non-specific uptake of IFN-a by degenerat-","author":"Jilbert, A.R.; Burrell, C.J.; Gowans, E.J.; Hertzog, P.J.; Linnane, A.W.; Marmion, B.P.","unstructured":"Jilbert AR, Burrell CJ, Gowans EJ, Hertzog PJ, Linnane AW, Marmion BP. Cellular localisation of alpha-interferon in Using the techniques described here, we can only hepatitis B virus-infected liver tissue. Hepatology 1986;6: speculate as to whether hepatocytes actually synthesise IFN-a or are engaged in its uptake from surrounding cells. Non-specific uptake of IFN-a by degenerat- 957-61."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1146\/annurev.bi.56.070187.003455","article-title":"Interferons and their actions","volume":"56","author":"Pestka, S.; Langer, J.A.; Zoon, K.C.; Samuel, C.E.","year":"1987","unstructured":"Pestka S, Langer JA, Zoon KC, Samuel CE. Interferons and their actions. Ann Rev Biochem 1987;56:727-77.","journal-title":"Ann Rev Biochem"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.42.10.1065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T02:18:12Z","timestamp":1764987492000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.42.10.1065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":5,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1989,10,1]]},"published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1136\/jcp.42.10.1065"],"URL":"https:\/\/doi.org\/10.1136\/jcp.42.10.1065","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}