{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:39Z","timestamp":1760188899052,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:p>The incidence of mucocutaneous herpes simplex virus infection confirmed by culture and occurring during febrile neutropenic episodes was determined in 43 patients with haematological malignancy. The outcome of 72 episodes of neutropenic fever was determined and correlated with the presence or absence of herpes simplex virus (HSV) infection. Twenty four patients had mucocutaneous HSV infection during at least one episode. In 24 episodes in which HSV was isolated only 12.5% of fevers responded to antibiotics and 75% of fevers were otherwise unexplained. Conversely, in 48 episodes of neutropenic fever in which HSV was not isolated 67% of fevers responded to antibiotics and only 8.3% were unexplained. The difference in incidence of antibiotic resistant fever in the two groups was significant. There was, therefore, a strong association between mucocutaneous HSV infection and antibiotic resistant fever in immunosuppressed neutropenic patients. As most HSV infections are the result of virus reactivation, establishing the HSV serological state of patients would identify those at risk of infection and hence those in whom the prophylactic use of acyclovir would be indicated.<\/jats:p>","DOI":"10.1136\/jcp.42.12.1255","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1255-1258","source":"Crossref","is-referenced-by-count":16,"title":["Antibiotic resistant fever associated with herpes simplex virus infection in neutropenic patients with haematological malignancy."],"prefix":"10.1136","volume":"42","author":[{"given":"T P","family":"Baglin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"Gray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R E","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T G","family":"Wreghitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1128\/AAC.29.2.263","article-title":"European Organisation for Research on Treatment of Cancer Antimicrobial Therapy Project Group. 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Ceftazidime combined with a short or long course of Amikacin for empirical therapy of gram-negative bacteraemia in cancer patients with granulocytopenia","year":"1987","unstructured":"The EORTC International Antimicrobial Therapy Cooperative Group. Ceftazidime combined with a short or long course of Amikacin for empirical therapy of gram-negative bacteraemia in cancer patients with granulocytopenia. N Engl J Med 1987: 1692-8.","journal-title":"N Engl J Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0308-2261(21)00445-8","article-title":"Rational basis for the choice of regimens for empirical therapy of sepsis in granulocytopenic patients","volume":"13","author":"Gaya, H.","year":"1984","unstructured":"Gaya H. Rational basis for the choice of regimens for empirical therapy of sepsis in granulocytopenic patients. Clin Haematol 1984;13:573-86.","journal-title":"Clin Haematol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0002-9343(72)90012-5","article-title":"Herpes simplex infections in haematological malignancies","volume":"52","author":"Muller, S.A.; Hermann, E.C.; Winklemann, R.K.","year":"1972","unstructured":"Muller SA, Hermann EC, Winklemann RK. Herpes simplex infections in haematological malignancies. Am J Med 1972;52: 102-14.","journal-title":"Am J Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1002\/1097-0142(19811115)48:10<2168::AID-CNCR2820481009>3.0.CO;2-B","article-title":"Herpes simplex infrction in acute myelogenous leukemia and other hematologic malignancies: A prospective study","volume":"48","author":"Lam, M.T.; Pazin, G.J.; Armstrong, J.A.; Monto, H.O.","year":"1981","unstructured":"Lam MT, Pazin GJ, Armstrong JA, Monto HO. Herpes simplex infrction in acute myelogenous leukemia and other hematologic malignancies: A prospective study. Cancer 1981;48:2168-71.","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.7326\/0003-4819-96-3-265","article-title":"Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation","volume":"96","author":"Wade, J.C.; Newton, B.; McLaren, C.; Flournoy, N.; Keeney, R.E.; Meyers, J.D.","year":"1982","unstructured":"Wade JC, Newton B, McLaren C, Flournoy N, Keeney RE, Meyers JD. Intravenous acyclovir to treat mucocutaneous herpes simplex virus infection after marrow transplantation. 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A randomised double blind, placebo controlled trial","volume":"50","author":"Anderson, H.; Scarffe, J.H.; Sutton, R.N.P.; Hickmott, E.; Brigden, D.; Burke, C.","year":"1984","unstructured":"Anderson H, Scarffe JH, Sutton RNP, Hickmott E, Brigden D, Burke C. Oral acyclovir prophylaxis against herpes simplex virus in non-Hodgkin lymphoma and acute lymphoblastic leukaemia patients receiving remission induction chemotherapy. A randomised double blind, placebo controlled trial. Br J Cancer 1984;50:45-9.","journal-title":"Br J Cancer"},{"key":"ref_10","first-page":"1452","article-title":"Septicaemia caused by viridans streptococci in neutropenic patients with leukaemia","volume":"ii:","author":"Cohen, J.; Worsley, A.M.; Goldman, J.M.; Donnelly, J.P.; Catovsky, D.; Galton, D.A.G.","year":"1983","unstructured":"Cohen J, Worsley AM, Goldman JM, Donnelly JP, Catovsky D, Galton DAG. Septicaemia caused by viridans streptococci in neutropenic patients with leukaemia. 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