{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T19:00:16Z","timestamp":1766516416536,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:p>Between 1983 and 1987, 62 out of 76519 pregnancies in 51 mothers had a positive miniaturised Treponema pallidum haemagglutination assay (TPHA) test--1 in 1234, or 0.81 per 1000 births. About two thirds of these mothers had syphilis and the remainder non-venereal treponematoses such as yaws or pinta. Antenatal screening identified 13 patients with previously unknown acquired syphilis, 11 of whom were given antibiotics during pregnancy. There were six fetal losses among the 62 TPHA positive pregnancies, but none had evidence of congenital syphilis. No live born child in this study group showed stigmata of congenital syphilis. It is concluded that despite the current low incidence of syphilis in the United Kingdom it is imperative to continue antenatal serological screening and to emphasise the importance of early adequate treatment of the infection.<\/jats:p>","DOI":"10.1136\/jcp.42.12.1281","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1281-1284","source":"Crossref","is-referenced-by-count":15,"title":["Serological screening tests for syphilis in pregnancy: results of a five year study (1983-87) in the Oxford region."],"prefix":"10.1136","volume":"42","author":[{"given":"P","family":"Bowell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Mayne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Puckett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Entwistle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Selkon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,12,1]]},"reference":[{"key":"ref_1","first-page":"38","article-title":"Syphilis: clinical features. In: ABC of sexually transmitted diseases","author":"MW, I.Adler","year":"1984","unstructured":"I Adler MW. Syphilis: clinical features. In: ABC of sexually transmitted diseases. London: British Medical Association, 1984:38-48."},{"key":"ref_2","first-page":"57","article-title":"Cost benefit analysis of a prenatal preventive programme against congenital syphilis","volume":"3","author":"Stray-Pederson, B.","year":"1980","unstructured":"Stray-Pederson B. Cost benefit analysis of a prenatal preventive programme against congenital syphilis. National Institute of Public Health (Oslo) Annals 1980;3:57-66.","journal-title":"National Institute of Public Health (Oslo) Annals"},{"key":"ref_3","first-page":"27","article-title":"Lecture notes on sexually transmitted diseases","author":"Nicol-Thin, R.","year":"1982","unstructured":"Nicol-Thin R. Lecture notes on sexually transmitted diseases. Oxford: Blackwell Scientific Publications, 1982:27-101."},{"key":"ref_4","first-page":"6","article-title":"Syphilis","volume-title":"Sexually transmitted diseases","author":"Sequeira, P.J.L.","year":"1987","unstructured":"Sequeira PJL. Syphilis. In: Jephcott AE, ed. Sexually transmitted diseases. London: PHLS, 1987:6-22."},{"key":"ref_5","first-page":"68","article-title":"Prevention of congenital syphilis","volume":"40","author":"Chattopadhyay, B.","year":"1988","unstructured":"Chattopadhyay B. Prevention of congenital syphilis. Br J Hosp Med 1988;40:68-70.","journal-title":"Br J Hosp Med"},{"key":"ref_6","first-page":"37","article-title":"Screening for syphilis in pregnancy; an assessment of the costs and benefits","volume":"7","author":"Williams, K.","year":"1985","unstructured":"Williams K. Screening for syphilis in pregnancy; an assessment of the costs and benefits. Community Med 1985;7:37-42.","journal-title":"Community Med"},{"key":"ref_7","first-page":"393","article-title":"Centre for Disease Control. Current trends: increases in primary and secondary syphilis in the United States","volume":"36","year":"1987","unstructured":"Centre for Disease Control. Current trends: increases in primary and secondary syphilis in the United States. MMWR 1987;36: 393-6.","journal-title":"MMWR"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1136\/jcp.35.12.1349","article-title":"Modification of the system of screening for antisyphilis antibodies in a blood transfusion centre, featuring a miniaturisation of the Treponema pallidum haemagglutination assay","volume":"35","author":"Puckett, A.; Pratt, G.","year":"1982","unstructured":"Puckett A, Pratt G. Modification of the system of screening for antisyphilis antibodies in a blood transfusion centre, featuring a miniaturisation of the Treponema pallidum haemagglutination assay. J Clin Pathol 1982;35:1349-52.","journal-title":"J Clin Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1136\/jcp.40.11.1337","article-title":"Syphilis screening in the Blood Transfusion Service: a report of four years experience with the Treponema pallidum haemagglutination assay and the subsequent development of a rapid spin method","volume":"40","author":"Puckett, A.; Pratt, G.","year":"1987","unstructured":"Puckett A, Pratt G. Syphilis screening in the Blood Transfusion Service: a report of four years experience with the Treponema pallidum haemagglutination assay and the subsequent development of a rapid spin method. J Clin Pathol 1987;40:1337-9.","journal-title":"J Clin Pathol"},{"key":"ref_10","first-page":"147","article-title":"Antenatal screening for syphilis","volume":"57","author":"Wright, D.J.M.; Gerken, A.","year":"1981","unstructured":"Wright DJM, Gerken A. Antenatal screening for syphilis. Br J Vener Dis 1981;57:147-8.","journal-title":"Br J Vener Dis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1479-828X.1981.tb00133.x","article-title":"The cost of routine antenatal screening for syphilis","volume":"21","author":"Bryce, R.L.; Pritchard, R.C.","year":"1981","unstructured":"Bryce RL, Pritchard RC. The cost of routine antenatal screening for syphilis. Aust NZ J Obstet Gynaecol 1981;21:211-3.","journal-title":"Aust NZ J Obstet Gynaecol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.42.12.1281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T07:01:31Z","timestamp":1765695691000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.42.12.1281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,12]]},"references-count":11,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1989,12,1]]},"published-print":{"date-parts":[[1989,12]]}},"alternative-id":["10.1136\/jcp.42.12.1281"],"URL":"https:\/\/doi.org\/10.1136\/jcp.42.12.1281","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1989,12]]}}}