{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:33:24Z","timestamp":1765730004171,"version":"3.48.0"},"reference-count":20,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:p>Seventy six peripheral T cell lymphomas were examined immunohistologically to test their reactivity with a panel of monoclonal antibodies against 11 T cell associated antigens (CD1-8, CD27, UCHL1, and the T cell antigen receptor). Sixty two (82%) lymphomas showed aberrant phenotypes, and four main categories were distinguished as follows: (i) lack of one or several pan-T cell antigens (49, 64% of the cases); (ii) loss of both the CD4 and CD8 antigens (11, 15% of the cases); (iii) coexpression of the CD4 and CD8 antigens (13, 17% of the cases); and (iv) expression of the CD1 antigen (eight, 11% of the cases). No correlation was seen between the occurrence of aberrant phenotypes and the histological subtype. It is concluded that the demonstration of an aberrant phenotype is a valuable supplement to histological assessment in the diagnosis of peripheral T cell lymphomas. It is recommended that the panel of monoclonal antibodies against T cell differentiation antigens should be fairly large, as apparently any antigen may be lost in the process of malignant transformation.<\/jats:p>","DOI":"10.1136\/jcp.42.4.398","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"398-402","source":"Crossref","is-referenced-by-count":46,"title":["Aberrant phenotypes in peripheral T cell lymphomas."],"prefix":"10.1136","volume":"42","author":[{"given":"N","family":"Hastrup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Ralfkiaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Pallesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,4,1]]},"reference":[{"key":"ref_1","first-page":"181","article-title":"Pallesen Immunophenotypic criteria for the diagnosis of non-Hodgkin's lymphoma","volume":"128","author":"Picker, L.J.; Weiss, L.M.; Medeiros, L.J.; Wood, G.S.; Hastrup, Warnke R.A.; RalJkiaer","year":"1987","unstructured":"Picker LJ, Weiss LM, Medeiros LJ, Wood GS, Warnke RA. Hastrup, RalJkiaer, Pallesen Immunophenotypic criteria for the diagnosis of non-Hodgkin's lymphoma. Am J Pathol 1987;128:181-201.","journal-title":"Am J Pathol"},{"key":"ref_2","first-page":"1","article-title":"Immunophenotypic markers for characterizing malignant lymphoma, malignant histiocytosis and tumors derived from accessory cells","volume":"8","author":"Pallesen, G.","year":"1988","unstructured":"Pallesen G. Immunophenotypic markers for characterizing malignant lymphoma, malignant histiocytosis and tumors derived from accessory cells. Cancer Rev 1988;8:1-65.","journal-title":"Cancer Rev"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/ajcp\/84.5.610","article-title":"Phenotypic characterization oflymphocyte subsets in mycosis fungoides. 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