{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:59:52Z","timestamp":1764997192920,"version":"3.46.0"},"reference-count":25,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p>The association between asymptomatic primary sclerosing cholangitis and exocrine pancreatic disease was underlined by the findings in a patient with cystic fibrosis and in another with chronic pancreatitis. In each case hepatocytes showed extensive microvesicular steatosis and studies of drug metabolism suggested hepatic enzyme induction: biliary or serum analysis, or both, disclosed raised concentrations of a lipid-based marker of free radical oxidation. These findings suggest that toxic metabolites of oxygen or other chemicals may have a role in the pathogenesis of the bile duct lesion.<\/jats:p>","DOI":"10.1136\/jcp.42.5.466","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"466-469","source":"Crossref","is-referenced-by-count":8,"title":["Sclerosing cholangitis with hepatic microvesicular steatosis in cystic fibrosis and chronic pancreatitis."],"prefix":"10.1136","volume":"42","author":[{"given":"I","family":"Benett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Salh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N Y","family":"Haboubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Braganza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0016-5085(81)80027-3","article-title":"Gastrointestinal manifestations of cystic fibrosis","volume":"81","author":"RW, I.Park; RJ, Grand","year":"1981","unstructured":"I Park RW, Grand RJ. Gastrointestinal manifestations of cystic fibrosis. Gastroenterology 1981;81:1143-61.","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/ajcp\/42.5.451","article-title":"Ultrastructural changes of the pancreas and liver in cystic fibrosis","volume":"42","author":"Porta, E.A.; Stein, A.A.; Patterson, P.","year":"1964","unstructured":"Porta EA, Stein AA, Patterson P. Ultrastructural changes of the pancreas and liver in cystic fibrosis. Am J Clin Pathol 1964; 42:451-65.","journal-title":"Am J Clin Pathol"},{"key":"ref_3","article-title":"Pathology of the liver","author":"MacSween, R.N.M.; Anthony, P.; Scheuer, P.","year":"1987","unstructured":"MacSween RNM, Anthony P, Scheuer P. Pathology of the liver. 2nd edition. London: Churchill Livingstone, 1987.","edition":"2nd edition"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0009-9260(85)80022-2","article-title":"Sclerosing cholangitislike changes in pancreatic disease","volume":"36","author":"Warwick, F.; Anderson, R.J.L.; Braganza, J.M.","year":"1985","unstructured":"Warwick F, Anderson RJL, Braganza JM. Sclerosing cholangitislike changes in pancreatic disease. Clin Radiol 1985;36:51-6.","journal-title":"Clin Radiol"},{"key":"ref_5","first-page":"380","article-title":"Liver histology in patients with pancreatitis: a clue to aetiology?","volume":"53","author":"Haboubi, N.Y.; Ali, H.H.; Braganza, J.M.","year":"1986","unstructured":"Haboubi NY, Ali HH, Braganza JM. Liver histology in patients with pancreatitis: a clue to aetiology? Mt Sinai J Med 1986; 53:380-8.","journal-title":"Mt Sinai J Med"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0009-8981(84)90231-6","article-title":"Altered clearance of sulphobromophthalein (BSP) in patients with pancreatic disease","volume":"138","author":"Braganza, J.M.","year":"1984","unstructured":"Braganza JM. Altered clearance of sulphobromophthalein (BSP) in patients with pancreatic disease. Clin Chim Acta 1984;138: 163-73.","journal-title":"Clin Chim Acta"},{"key":"ref_7","series-title":"Proceedings Vllth International Cystic Fibrosis Congress","first-page":"463","article-title":"Predive value of BSP kinetics for early liver involvement in cystic fibrosis","author":"Grand, R.J.; Lebenthal, E.; Jacobson, M.; Kevy, S.; Swachman, H.","year":"1978","unstructured":"Grand RJ, Lebenthal E, Jacobson M, Kevy S, Swachman H. Predive value of BSP kinetics for early liver involvement in cystic fibrosis. Proceedings Vllth International Cystic Fibrosis Congress, Paris. Paris: Jouve, 1978:463-8."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1164\/arrd.1983.127.4.417","article-title":"Theophylline disposition in cystic fibrosis","volume":"127","author":"Isles, M.; Spino, M.; Tabachnik, E.; Levison, H.; Thiesson, J.; MacLeod, S.","year":"1983","unstructured":"Isles M, Spino M, Tabachnik E, Levison H, Thiesson J, MacLeod S. Theophylline disposition in cystic fibrosis. Am Rev Respir Dis 1983;127:417-21.","journal-title":"Am Rev Respir Dis"},{"key":"ref_9","first-page":"73","article-title":"Induction of cytochromes P450 in pancreatic disease: consequence, coincidence or cause? Clin Chim Acda","volume":"151","author":"Acheson, D.W.K.; Rose, P.; Houston, J.B.; Braganza, J.M.","year":"1985","unstructured":"Acheson DWK, Rose P, Houston JB, Braganza JM. Induction of cytochromes P450 in pancreatic disease: consequence, coincidence or cause? Clin Chim Acda 1985;151:73-84."},{"issue":"18","key":"ref_10","first-page":"\"1","article-title":"Microsomal drug metabolism in cystic fibrosis","volume":"74","author":"Salh, B.; Webb, K.; Braganza, J.M.; Sandle, L.R.","year":"1988","unstructured":"Salh B, Webb K, Braganza JM, Sandle LR. Microsomal drug metabolism in cystic fibrosis. Clin Sci 1988;74(suppl 18):1-20. 1 1 Sandle LR, Braganza JM. An evaluation of the low-pH enzymatic assay of urinary D-glucaric acid, and its use as a marker of enzyme induction in exocrine pancreatic disease. Clin Chim Acda 1987;162:245-56.","journal-title":"Clin Sci; An evaluation of the low-pH enzymatic assay of urinary D-glucaric acid, and its use as a marker of enzyme induction in exocrine pancreatic disease"},{"key":"ref_11","first-page":"167","article-title":"Free radical activity and diene conjugation in man","volume-title":"radicals in liver injury","author":"Dormandy, T.L.","year":"1985","unstructured":"Dormandy TL. Free radical activity and diene conjugation in man. In: Poli G, Cheeseman KH, Dianzani MU, eds. Free radicals in liver injury. Oxford: IRL Press, 1985:167-74."},{"key":"ref_12","first-page":"18","article-title":"Heightened free radical activity in patients with pancreatitis","volume":"74","author":"Uden, S.; Guyan, P.M.; Kay, P.; Kay, G.H.; Braganza, J.M.","year":"1988","unstructured":"Uden S, Guyan PM, Kay P, Kay GH, Braganza JM. Heightened free radical activity in patients with pancreatitis. Clin Sci 1988;74(suppl 18):1-32.","journal-title":"Clin Sci"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0306-9877(86)90129-5","article-title":"Cystic Fibrosis: a casualty of \"detoxification\"?","volume":"20","author":"Braganza, J.M.","year":"1986","unstructured":"Braganza JM. Cystic Fibrosis: a casualty of \"detoxification\"? Med Hypoth 1986;20:233-43.","journal-title":"Med Hypoth"},{"key":"ref_14","first-page":"19","article-title":"The role of the liver in exocrine pancreatic disease","volume":"3","author":"Braganza, J.M.","year":"1988","unstructured":"Braganza JM. The role of the liver in exocrine pancreatic disease. Int J Pancreatol 1988;3:S19-S42.","journal-title":"Int J Pancreatol"},{"key":"ref_15","first-page":"717","article-title":"Sclerosing cholangitis associated with hepatic arterial FUDL chemotherapy: radiographic-histologic correlation","volume":"146","author":"Shea, W.J.; Demas, B.E.; Goldberg, H.I.; Hohn, D.C.; Ferrell, L.D.; Kerlan, R.K.","year":"1986","unstructured":"Shea WJ, Demas BE, Goldberg HI, Hohn DC, Ferrell LD, Kerlan RK. Sclerosing cholangitis associated with hepatic arterial FUDL chemotherapy: radiographic-histologic correlation. Am J Radiol 1986;146:717-26.","journal-title":"Am J Radiol"},{"issue":"10","key":"ref_16","first-page":"108","article-title":"Experimental sclerosing cholangitis in rat induced by formalin injection in the biliary tract","volume":"31","author":"S. Schrumpf E, 0, Doblough JH, Ritland S, Thorsby E.","year":"1986","unstructured":"Houry S, Languille 0, Hugier M. Experimental sclerosing cholangitis in rat induced by formalin injection in the biliary tract. Dig Dis Sci 1986;31(suppl 10):108 S. 18 Schrumpf E, Fansa 0, F0rree 0, Doblough JH, Ritland S, Thorsby E. HLA antigens and immunoregulatory T cells in ulcerative colitis associated with hepatobiliary disease. Scand J Gastroenterol 1982;17:187-91.","journal-title":"Dig Dis Sci; HLA antigens and immunoregulatory T cells in ulcerative colitis associated with hepatobiliary disease"},{"key":"ref_17","first-page":"422","article-title":"Expression of HLA-DR antigens on bile duct epithelium in primary sclerosing cholangitis","volume":"22","author":"Chapman, R.W.; Kelly, P.M.A.; Heryet, A.; Jewell, D.P.; Fleming, K.A.","year":"1988","unstructured":"Chapman RW, Kelly PMA, Heryet A, Jewell DP, Fleming KA. Expression of HLA-DR antigens on bile duct epithelium in primary sclerosing cholangitis. Gut 1988;22:422-7.","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02795235","article-title":"Occupational volatile chemicals and pancreatitis: a link?","volume":"1","author":"Braganza, J.M.; Jolley, J.E.; Lee, W.R.","year":"1986","unstructured":"Braganza JM, Jolley JE, Lee WR. Occupational volatile chemicals and pancreatitis: a link? Int J Pancreatol 1986;1:9-20.","journal-title":"Int J Pancreatol"},{"key":"ref_19","first-page":"375","article-title":"Lipid peroxidation (free radical oxidation) products in bile from patients with pancreatic disease","volume":"ii:","author":"Braganza, J.M.; Wickens, D.; Cawood, P.; Dormandy, T.L.","year":"1983","unstructured":"Braganza JM, Wickens D, Cawood P, Dormandy TL. Lipid peroxidation (free radical oxidation) products in bile from patients with pancreatic disease. Lancet 1983;ii:375-9.","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02788226","article-title":"HLA-A and B antigens in chronic pancreatitis","volume":"3","author":"Anderson, R.J.L.; Dyer, P.; Donnai, D.; Braganza, J.M.","year":"1988","unstructured":"Anderson RJL, Dyer P, Donnai D, Braganza JM. HLA-A and B antigens in chronic pancreatitis. Int J Pancreatol 1988;3:83-90.","journal-title":"Int J Pancreatol"},{"key":"ref_21","first-page":"243","article-title":"Muscoviscidose et marquers HLA-A et B. Proceedings Vllth International Cystic Fibrosis Congress","author":"HennequetA, Jehanne M.; HorsJ, SchmidJ; M, Schmid; DaussetJ","year":"1978","unstructured":"HennequetA, Jehanne M, HorsJ, SchmidJ, Schmid M, DaussetJ. Muscoviscidose et marquers HLA-A et B. Proceedings Vllth International Cystic Fibrosis Congress, Paris. Paris: Jouve, 1978:243-7."},{"key":"ref_22","series-title":"Proceedings of VlIth International Cystic Fibrosis Congress","first-page":"74","article-title":"Ultrastructure of the liver in cystic fibrosis","author":"Ch, Dominick H.; von Bassenwitz DB; P, Arends","year":"1978","unstructured":"Dominick H Ch, von Bassenwitz DB, Arends P. Ultrastructure of the liver in cystic fibrosis. Proceedings of VlIth International Cystic Fibrosis Congress, Paris. Paris: Jouve, 1978:74-7."},{"key":"ref_23","article-title":"Aberrant free radical activity in cystic fibrosis","author":"Salh, B.; Webb, K.; Guyan, P.M.","unstructured":"Salh B, Webb K, Guyan PM, et al. Aberrant free radical activity in cystic fibrosis. Clin Chim Acta (in press).","journal-title":"Clin Chim Acta"},{"key":"ref_24","series-title":"Proceedings of VIlth International Cystic Fibrosis Congress","first-page":"127","article-title":"The ultrastuctural investigation of nasal mucosa glands in patients with mucoviscidosis","author":"Gavalor, S.M.; Mezhevitch, N.A.; Buzueva, II","year":"1978","unstructured":"Gavalor SM, Mezhevitch NA, Buzueva II. The ultrastuctural investigation of nasal mucosa glands in patients with mucoviscidosis. Proceedings of VIlth International Cystic Fibrosis Congress, Paris. Paris: Jouve, 1978:127-31."},{"key":"ref_25","first-page":"469","article-title":"Cystic fibrosis: a perinatal manifestation of selenium deficiency","volume-title":"substances in environmental health","author":"Wallach, J.D.; Germaise, B.","year":"1979","unstructured":"Wallach JD, Germaise B. Cystic fibrosis: a perinatal manifestation of selenium deficiency. In: Hemphil DD, ed. Trace substances in environmental health. Columbia: University of Missouri Press, 1979:469-76."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.42.5.466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:49:58Z","timestamp":1764996598000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.42.5.466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1989,5,1]]},"published-print":{"date-parts":[[1989,5]]}},"alternative-id":["10.1136\/jcp.42.5.466"],"URL":"https:\/\/doi.org\/10.1136\/jcp.42.5.466","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1989,5]]}}}