{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:55:41Z","timestamp":1765691741384,"version":"3.48.0"},"reference-count":21,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:p>The distribution of laminin, a basement membrane glycoprotein, was studied by an immunohistochemical technique in six samples of benign sclerosing lesions of extrahepatic bile ducts and in 11 sclerosing cholangiocarcinomas. The expression of laminin showed that benign glandular structures were surrounded by a mainly intact basement membrane. In sclerosing cholangiocarcinomas laminin was irregularly distributed, and in large areas totally absent. The findings suggest that deposition of basement membrane material is defective. Sclerosing cholangitis may be extremely difficult to distinguish from well differentiated sclerosing cholangiocarcinoma. This sample was small, but the diseases studied were relatively rare. Staining for laminin might be of additional use to surgical pathologists in the differential diagnosis of benign sclerosing lesions and sclerosing cholangiocarcinomas.<\/jats:p>","DOI":"10.1136\/jcp.42.9.927","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"927-930","source":"Crossref","is-referenced-by-count":3,"title":["Expression of laminin in benign and malignant sclerosing lesions of extrahepatic bile ducts."],"prefix":"10.1136","volume":"42","author":[{"given":"C","family":"Haglund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nordling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1989,9,1]]},"reference":[{"key":"ref_1","first-page":"870","article-title":"Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology","volume-title":"Gut","volume":"21","author":"Chapman, R.W.G.; Arborgh, B.A.M.; Rhodes, J.M.","year":"1980","unstructured":"Chapman RWG, Arborgh BAM, Rhodes JM, et al. Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology. Gut 1980;21:870-7."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0039-6109(16)42491-6","article-title":"Primary sclerosing cholangitis","volume":"61","author":"LF, Jr, Williams; JD, Jr, Schoetz","year":"1981","unstructured":"Williams LF Jr, Schoetz JD Jr. Primary sclerosing cholangitis. Surg Clin North Am 1981;61:951-62.","journal-title":"Surg Clin North Am"},{"key":"ref_3","first-page":"157","article-title":"Primary sclerosing cholangitis","volume":"1","author":"Lefkowitch, J.H.","year":"1982","unstructured":"Lefkowitch JH. Primary sclerosing cholangitis. Arch Intern Med 1982;142:1 157-60.","journal-title":"Arch Intern Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/path.1711390210","article-title":"Pathological aspects ofcholangiocarcinoma","volume":"139","author":"Weinbren, K.; Mutum, S.S.","year":"1983","unstructured":"Weinbren K, Mutum SS. Pathological aspects ofcholangiocarcinoma. J Pathol 1983;139:217-38.","journal-title":"J Pathol"},{"key":"ref_5","first-page":"5076","article-title":"Basement membrane changes in breast cancer detected by immunochemical staining for laminin","volume":"41","author":"Albrechtsen, R.; Nielsen, M.; Wewer, U.; Engvall, E.; Ruoslahti, E.","year":"1981","unstructured":"Albrechtsen R, Nielsen M, Wewer U, Engvall E, Ruoslahti E. Basement membrane changes in breast cancer detected by immunochemical staining for laminin. Cancer Res 1981;41:5076-8 1.","journal-title":"Cancer Res"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ijc.2910300104","article-title":"Antigens of the basement membrane and the peritumoral stroma in human colonic adenocarcinomas: An immunofluorescence study","volume":"30","author":"Burtin, P.; Chavanel, G.; Foidart, J.M.; Martin, E.","year":"1982","unstructured":"Burtin P, Chavanel G, Foidart JM, Martin E. Antigens of the basement membrane and the peritumoral stroma in human colonic adenocarcinomas: An immunofluorescence study. Int J Cancer 1982;30:13-20.","journal-title":"Int J Cancer"},{"key":"ref_7","first-page":"25","article-title":"Distribution of laminin, a basement membrane glycoprotein in epithelial proliferations","volume-title":"Collat Rel Res 1983; 3","author":"Ph, Birembaut; Y, Caron; van Cauwen-Berge D; JM, Foidart","unstructured":"Birembaut Ph, Caron Y, van Cauwen-Berge D, Foidart JM. Distribution of laminin, a basement membrane glycoprotein in epithelial proliferations. Collat Rel Res 1983;3:25-31."},{"key":"ref_8","first-page":"636","article-title":"Tumor invasion and the extracellular matrix","volume":"49","author":"Liotta, L.A.; Rao, C.N.; Barsky, S.H.","year":"1983","unstructured":"Liotta LA, Rao CN, Barsky SH. Tumor invasion and the extracellular matrix. Lab Invest 1983;49:636-49.","journal-title":"Lab Invest"},{"key":"ref_9","first-page":"656","article-title":"The basement membrane in pathology","volume":"48","author":"Martinez-Hernandez, A.; Amenta, P.S.","year":"1983","unstructured":"Martinez-Hernandez A, Amenta PS. The basement membrane in pathology. Lab Invest 1983;48:656-77.","journal-title":"Lab Invest"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1136\/jcp.37.4.357","article-title":"Basement membrane and apocrine epithelial antigens in differential diagnosis between tubular carcinoma and sclerosing adenosis of the breast","volume":"37","author":"Ekblom, P.; Miettinen, M.; Forsman, L.; Andersson, L.C.","year":"1984","unstructured":"Ekblom P, Miettinen M, Forsman L, Andersson LC. Basement membrane and apocrine epithelial antigens in differential diagnosis between tubular carcinoma and sclerosing adenosis of the breast. J Clin Pathol 1984;37:357-63.","journal-title":"J Clin Pathol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00000478-198409000-00006","article-title":"Expression of laminin in pancreatic neoplasms and in chronic pancreatitis","volume":"8","author":"Haglund, C.; Roberts, P.J.; Nordling, S.; Ekblom, P.","year":"1984","unstructured":"Haglund C, Roberts PJ, Nordling S, Ekblom P. Expression of laminin in pancreatic neoplasms and in chronic pancreatitis. Am J Surg Pathol 1984;8:669-76.","journal-title":"Am J Surg Pathol"},{"key":"ref_12","first-page":"285","article-title":"Malignant transformation in human colorectal mucosa as monitored by distribution of laminin, a basement membrane glycoprotein. Acda Pathol Microbiol Immunol Scand (Sect A)","volume":"93","author":"Kellokumpu, I.; Ekblom, P.; Scheinin, T.M.","year":"1985","unstructured":"Kellokumpu I, Ekblom P, Scheinin TM, et al. Malignant transformation in human colorectal mucosa as monitored by distribution of laminin, a basement membrane glycoprotein. Acda Pathol Microbiol Immunol Scand (Sect A) 1985;93:285-91."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1136\/jcp.40.12.1418","article-title":"Distribution of basement membrane antigens in clinical gastric adenocarcinomas: an immunohistochemical study","volume":"40","author":"Nakamura, K.; Mori, M.; Enjoji, M.","year":"1987","unstructured":"Nakamura K, Mori M, Enjoji M. Distribution of basement membrane antigens in clinical gastric adenocarcinomas: an immunohistochemical study. J Clin Pathol 1987;40:1418-23.","journal-title":"J Clin Pathol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1084\/jem.145.1.204","article-title":"A murine tumor producing a matrix of basement membrane","volume":"145","author":"Orkin, R.W.; Gehron, P.; McGoodwin, E.B.; Martin, G.R.; Valentine, T.; Swarm, R.H.","year":"1977","unstructured":"Orkin RW, Gehron P, McGoodwin EB, Martin GR, Valentine T, Swarm RH. A murine tumor producing a matrix of basement membrane. J Exp Med 1977;145:204-20.","journal-title":"J Exp Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9933","DOI":"10.1016\/S0021-9258(19)83607-4","article-title":"Laminin-A glycoprotein from basement membranes","volume":"254","author":"Timpl, R.; Rohde, H.; Robey, P.G.; Rennard, S.I.; Foidart, J.M.; Martin, G.R.","year":"1979","unstructured":"Timpl R,Rohde H, Robey PG, Rennard SI, Foidart JM, Martin GR. Laminin-A glycoprotein from basement membranes. J Biol Chem 1979;254:9933-7.","journal-title":"J Biol Chem"},{"key":"ref_16","first-page":"336","article-title":"Distribution and immunoelectron microscopic localisation of laminin, a non-collagenous basement membrane glycoprotein","volume":"42","author":"Foidart, J.M.; Bere, E.W.; Yaar, M.","year":"1980","unstructured":"Foidart JM, Bere EW, Yaar M, et al. Distribution and immunoelectron microscopic localisation of laminin, a non-collagenous basement membrane glycoprotein. Lab Invest 1980;42:336-42.","journal-title":"Lab Invest"},{"key":"ref_17","first-page":"119","article-title":"Basement membrane components","volume-title":"ofthe extracellular matrix","author":"Timpl, R.; Martin, G.R.","year":"1982","unstructured":"Timpl R, Martin GR. Basement membrane components. In: Furthmeyer H, ed. Immunochemistry ofthe extracellular matrix. Boca Raton, Florida: 1982:119-50."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF00496733","article-title":"Demonstration of laminin, a basement membrane glycoprotein, in routinely processed formalin-fixed human tissues","volume":"75","author":"Ekblom, P.; Miettinen, M.; Rapola, J.; Foidart, J.M.","year":"1982","unstructured":"Ekblom P, Miettinen M, Rapola J, Foidart JM. Demonstration of laminin, a basement membrane glycoprotein, in routinely processed formalin-fixed human tissues. Histochemistry 1982;75:301-7.","journal-title":"Histochemistry"},{"key":"ref_19","first-page":"550","article-title":"Secretion of proteinases from malignant and non-malignant human breast tissue","volume":"40","author":"Recklies, A.D.; Tiltman, K.J.; Stoker, A.M.; Poole, A.R.","year":"1980","unstructured":"Recklies AD, Tiltman KJ, Stoker AM, Poole AR. Secretion of proteinases from malignant and non-malignant human breast tissue. Cancer Res 1980;40:550-6.","journal-title":"Cancer Res"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1016\/S0021-9258(19)85756-3","article-title":"Immunological quantitation and immunoadsorption of urokinase-like plaminogen activators secreted by human cells","volume":"255","author":"Vetterlein, D.; Bell, T.E.; Young, P.L.; Roblin, R.","year":"1980","unstructured":"Vetterlein D, Bell TE, Young PL, Roblin R. Immunological quantitation and immunoadsorption of urokinase-like plaminogen activators secreted by human cells. J Biol Chem 1980;255:3665-72.","journal-title":"J Biol Chem"},{"key":"ref_21","first-page":"4629","article-title":"Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane","volume":"41","author":"Liotta, L.A.; Goldfarb, R.H.; Brundage, R.; Siegal, G.P.; Terranova, V.P.; Garbisa, S.","year":"1981","unstructured":"Liotta LA, Goldfarb RH, Brundage R, Siegal GP, Terranova VP, Garbisa S. Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane. Cancer Res 1981;41:4629-36.","journal-title":"Cancer Res"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.42.9.927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T05:50:54Z","timestamp":1765691454000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.42.9.927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":21,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1989,9,1]]},"published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1136\/jcp.42.9.927"],"URL":"https:\/\/doi.org\/10.1136\/jcp.42.9.927","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}