{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:11:08Z","timestamp":1758845468010,"version":"3.44.0"},"reference-count":5,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>Thirty six fine needle aspirates from various types of benign breast lesions were examined by electron microscopy and correlated with their cytological appearances. In all cases the parenchyma consisted of clumps of cohesive cells with the ultrastructural features of epithelial cells. In many cases, particularly from fibroadenomas, the parenchyma consisted of single layers of polarised epithelial cells showing lumen formation. Similar arrays of apocrine epithelial cells were observed in 60% of fibrocystic lesions. The more solid clumps from hyperplastic lesions consisted of epithelial cells of variable shape and electron density with disorganised lumen formation. Irrespective of the type of lesion, the epithelial cells were not normally subtended by myoepithelial cells or basal lamina. The extraction process seems to result in a shearing between the epithelium and basal lamina with lysis of the myoepithelial cells. Most naked nuclei probably result from lysed myoepithelial cells.<\/jats:p>","DOI":"10.1136\/jcp.43.1.22","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"22-26","source":"Crossref","is-referenced-by-count":2,"title":["Ultrastructural analysis of fine needle aspirates from benign breast lesions."],"prefix":"10.1136","volume":"43","author":[{"given":"D J","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C A","family":"Wells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Crucioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"ref_1","article-title":"Fine needle aspiration of the breast","author":"Oertel, Y.C.","year":"1987","unstructured":"Oertel YC. Fine needle aspiration of the breast. Boston: Butterworths, 1987."},{"key":"ref_2","first-page":"1","article-title":"Ultrastructure of the human mammary gland","volume":"6","author":"Ozzello, L.","year":"1971","unstructured":"Ozzello L. Ultrastructure of the human mammary gland. Pathol Annu 1971;6:1-59.","journal-title":"Pathol Annu"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/BF00216645","article-title":"An ultrastructural study of mitosis and cytokinesis in normal \"resting\" human breast","volume":"252","author":"Ferguson, D.J.P.","year":"1988","unstructured":"Ferguson DJP. An ultrastructural study of mitosis and cytokinesis in normal \"resting\" human breast. Cell Tissue Res 1988;252:581-7.","journal-title":"Cell Tissue Res"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/1097-0142(197003)25:3<586::AID-CNCR2820250314>3.0.CO;2-1","article-title":"Epithelial-stromal junction of normal and dysplastic mammary glands","volume":"25","author":"Ozzello, L.","year":"1970","unstructured":"Ozzello L. Epithelial-stromal junction of normal and dysplastic mammary glands. Cancer 1970;25:586-600.","journal-title":"Cancer"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0022-5320(83)90124-7","article-title":"Resting human female breast tissue produces iodinated protein","volume":"84","author":"Strum, J.M.; Phelps, P.C.; McAtee, M.M.","year":"1983","unstructured":"Strum JM, Phelps PC, McAtee MM. Resting human female breast tissue produces iodinated protein. J Ultrastruct Res 1983;84: 130-9.","journal-title":"J Ultrastruct Res"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.43.1.22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T08:47:09Z","timestamp":1758790029000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.43.1.22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1990,1,1]]},"published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1136\/jcp.43.1.22"],"URL":"https:\/\/doi.org\/10.1136\/jcp.43.1.22","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}