{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T14:58:42Z","timestamp":1765724322725,"version":"3.48.0"},"reference-count":19,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>The light microscopic, immunofluorescence, and electron microscopic appearances of renal biopsy specimens were reviewed and correlated with the clinical and laboratory findings in 61 patients in whom the findings were initially considered to be either normal or to show only minor non-specific abnormalities. In all cases this reassessment included quantitative measurement of glomerular basement membrane thickness by an orthogonal intercept technique. On the basis of the indication for biopsy, patients were classified into three groups: those with haematuria (group I, n = 41); those with a minor degree of proteinuria (group II, n = 16); and those without any urinary abnormality but in whom possible renal disease as a result of systemic disease was suspected (group III, n = 6). About half of the patients with haematuria had significantly thinner glomerular basement membranes than those in the other two groups, irrespective of the variable selected for assessment, and in three this was confirmed in follow up biopsy specimens. Follow up for up to eight years showed that in patients either with or without thin basement membranes haematuria commonly persisted, but the long term outlook in all three groups was otherwise good and no patient developed impaired renal function.<\/jats:p>","DOI":"10.1136\/jcp.43.1.32","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"32-38","source":"Crossref","is-referenced-by-count":19,"title":["Thin basement membranes in minimally abnormal glomeruli."],"prefix":"10.1136","volume":"43","author":[{"given":"S","family":"Saxena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R L","family":"Kirsner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/jcp.18.2.178","article-title":"Light and electron microscopic appearances in renal biopsy material of cases of recurrent heamaturia in children","volume":"18","author":"Lannigan, R.; Insley, J.","year":"1965","unstructured":"Lannigan R, Insley J. Light and electron microscopic appearances in renal biopsy material of cases of recurrent heamaturia in children. J Clin Pathol 1965;18:178-87.","journal-title":"J Clin Pathol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1136\/jcp.26.10.750","article-title":"Clinical light and electron microscopy findings in idiopathic haematuria","volume":"26","author":"Alexander, F.; Lannigan, R.; Bull, R.","year":"1973","unstructured":"Alexander F, Lannigan R, Bull R. Clinical light and electron microscopy findings in idiopathic haematuria. J Clin Pathol 1973;26:750-9.","journal-title":"J Clin Pathol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/archinte.1973.00320080093013","article-title":"Familial benign essential haematuria","volume":"131","author":"Rogers, P.W.; Kurtzman, N.A.; SM, Jr, Bunn; White, M.G.","year":"1973","unstructured":"Rogers PW, Kurtzman NA, Bunn SM Jr, White MG. Familial benign essential haematuria. 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Hum Pathol 1983;14:996-1003.","journal-title":"Hum Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/path.1711420403","article-title":"The thin glomerular basement membrane in children with haematuria","volume":"142","author":"Yoshikawa, N.; Hashimoto, H.; Katayama, Y.; Yamada, Y.; Matsuo, T.; Okada, S.","year":"1984","unstructured":"Yoshikawa N, Hashimoto H, Katayama Y, Yamada Y, Matsuo T, Okada S. The thin glomerular basement membrane in children with haematuria. J Pathol 1984;142:253-7.","journal-title":"J Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000166914","article-title":"Abnormally thin glomerular basement membrane associated with hematuria proteinuria or renal failure in adults","volume":"5","author":"Dische, F.E.; Weston, M.J.; Parsons, V.","year":"1985","unstructured":"Dische FE, Weston MJ, Parsons V. Abnormally thin glomerular basement membrane associated with hematuria proteinuria or renal failure in adults. Am J Nephrol 1985;5:103-9.","journal-title":"Am J Nephrol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/S0046-8177(86)80086-7","article-title":"Glomerular basement membrane abnormalities associated with apparently idiopathic hematuria: ultrastructural morphometric analysis","volume":"17","author":"Coleman, M.; Haynes, W.D.G.; Dimopoulos, P.; Barrat, L.J.; Jarvis, L.R.","year":"1986","unstructured":"Coleman M, Haynes WDG, Dimopoulos P, Barrat LJ, Jarvis LR. Glomerular basement membrane abnormalities associated with apparently idiopathic hematuria: ultrastructural morphometric analysis. 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Renal disease classification and atlas of glomerular diseases. Tokyo: Igaku-Shoin, 1982:35-6."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.43.1.32","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T14:54:34Z","timestamp":1765724074000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.43.1.32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":19,"journal-issue":{"issue":"1","published-online":{"date-parts":[[1990,1,1]]},"published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1136\/jcp.43.1.32"],"URL":"https:\/\/doi.org\/10.1136\/jcp.43.1.32","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}