{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:43:32Z","timestamp":1764996212235,"version":"3.46.0"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>As part of a study to assess the possible contribution of lymphoid infiltration of the gastrointestinal mucosa to occult blood loss or malabsorption 20 patients with chronic lymphocytic leukaemia (CLL) had a lactulose hydrogen breath test. In 10 cases (50%) a small intestinal peak was detected, suggesting small bowel bacterial overgrowth, and this was confirmed in seven patients by the positive culture of jejunal aspirate. Of the patients with a positive hydrogen breath test, radiological examination showed a duodenal diverticulum in two but no anatomical abnormalities in the other cases. There was no evidence of achlorhydria and transit times were normal. There was no difference in the incidence of hypogammaglobulinaemia among those patients with evidence of small intestinal bacterial overgrowth and those without. Seven patients with a positive hydrogen breath test, however, had undetectable secretory piece in their jejunal aspirates whereas this was present in all patients with a normal breath test who had local immunoglobulin concentrations measured (p less than 0.05), indicating that the small intestinal bacterial overgrowth may be due to impaired local immunity.<\/jats:p>","DOI":"10.1136\/jcp.43.1.57","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"57-59","source":"Crossref","is-referenced-by-count":10,"title":["Small intestinal bacterial overgrowth in patients with chronic lymphocytic leukaemia."],"prefix":"10.1136","volume":"43","author":[{"given":"G M","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"Chesner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Asquith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Leyland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1136\/gut.13.3.182","article-title":"Intestinal bacterial flora and bile salt studies in hypogammaglobulinaemia","volume":"13","author":"Parkin, D.M.; McClelland, D.B.L.; O'Moore, R.R.","year":"1972","unstructured":"Parkin DM, McClelland DBL, O'Moore RR, et al. Intestinal bacterial flora and bile salt studies in hypogammaglobulinaemia. Gut 1972;13:182-8.","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/jcp.40.7.756","article-title":"Immunogold-silver technique applied to showing malignant B cell infiltration of the gastrointestinal tract in patients with chronic lymphocytic leukaemia and nonHodgkin's lymphoma","volume":"40","author":"Smith, G.M.; Crocker, J.; Nar, P.; Chesner, I.; Leyland, M.J.","year":"1987","unstructured":"Smith GM, Crocker J, Nar P, Chesner I, Leyland MJ. Immunogold-silver technique applied to showing malignant B cell infiltration of the gastrointestinal tract in patients with chronic lymphocytic leukaemia and nonHodgkin's lymphoma. 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Scand J Gastroenterol 1979;14:333-6.","journal-title":"Scand J Gastroenterol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2141.1981.tb02727.x","article-title":"Chronic lymphocytic leukaemia: proposals for a revised prognostic staging system. Report from the International Workshop on CLL by the writing committee","volume":"48","author":"Binet, J.-L.; Catovsky, D.; Chandre, P.","year":"1981","unstructured":"Binet J-L, Catovsky D, Chandre P, et al. Chronic lymphocytic leukaemia: proposals for a revised prognostic staging system. Report from the International Workshop on CLL by the writing committee. 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Br Med J 1983;287:101 1-13.","journal-title":"Br Med J"},{"key":"ref_8","first-page":"487","article-title":"Bacteriology of the small gut and bacterial overgrowth","volume-title":"Textbook of gastroenterology","author":"Neale, G.","year":"1984","unstructured":"Neale G. Bacteriology of the small gut and bacterial overgrowth. In: Bouchier IAD, Allan RN, Hodgson HJF, Keighley MRB, eds. Textbook of gastroenterology. London: Bailliere Tindall, 1984:487-510."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0300-5089(21)00291-1","article-title":"The gut and immunodeficiency disorders","volume":"5","author":"Webster, A.D.B.","year":"1976","unstructured":"Webster ADB. The gut and immunodeficiency disorders. 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Edinburgh: Churchill Livingstone, 1979:152-82."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/226946a0","article-title":"Secretory piece linked to IgM in individuals deficient in IgA","volume":"226","author":"Thompson, R.A.","year":"1970","unstructured":"Thompson RA. Secretory piece linked to IgM in individuals deficient in IgA. 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