{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:23:25Z","timestamp":1765725805459,"version":"3.48.0"},"reference-count":14,"publisher":"BMJ","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p>Thirty four patients positive for human immunodeficiency virus (HIV) who had lymphadenopathy were investigated using fine needle aspiration. Cytological analysis included immunocytochemical investigation with the alkaline phosphatase-antialkaline phosphatase (APAAP) method. All patients had confirmation of cytological diagnosis by lymph node biopsy. Fifteen aspirates with follicular hyperplasia were evaluated. Eleven patients showed B cell predominance. The B cell population did not show light chain restriction. Ten patients with B cell non-Hodgkin's lymphoma (five with Burkitt's lymphoma and five with B cell immunoblastic lymphoma) were investigated. Nine out of 10 cases were monoclonal with respect to their light chain determinants; only one case with Burkitt's lymphoma with partial lymph node metastasis did not show light chain restriction. The cytological diagnosis included two mycobacterial infections and four cystic lesions. Histological investigation was necessary to diagnose the extent of lymph node disease caused by Kaposi's sarcoma. These findings indicate that the immunocytological investigation of lymph node aspirates is useful for evaluating lymphadenopathy in HIV positive patients.<\/jats:p>","DOI":"10.1136\/jcp.43.10.844","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"844-846","source":"Crossref","is-referenced-by-count":13,"title":["Immunocytochemical analysis of lymph node aspirates in patients with human immunodeficiency virus infection."],"prefix":"10.1136","volume":"43","author":[{"given":"J","family":"Oertel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Lobeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Huhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,10,1]]},"reference":[{"key":"ref_1","article-title":"Diagnostic cytology and its histopathological bases","author":"Koss, L.G.","year":"1979","unstructured":"Koss LG. Diagnostic cytology and its histopathological bases. Philadelphia: JB Lippincott Company, 1979."},{"key":"ref_2","first-page":"666","article-title":"Immunologic methods in cytology: definitive diagnosis of non-Hodgkin's lymphomas using immunologic markers for T-and B-cells","volume":"80","author":"Martin, S.E.; Zhang, H.Z.; Magyarosy, E.; Jaffe, E.S.; Hsu, S.; Chu, E.","year":"1984","unstructured":"Martin SE, Zhang HZ, Magyarosy E, Jaffe ES, Hsu S, Chu E. Immunologic methods in cytology: definitive diagnosis of non-Hodgkin's lymphomas using immunologic markers for T-and B-cells. Am J Clin Pathol 1984;80:666-73.","journal-title":"Am J Clin Pathol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0344-0338(78)80017-X","article-title":"How exact are the diagnosis and classification of malignant lymphomas from aspiration biopsy smears?","volume":"163","author":"Spieler, P.; Schmid, U.","year":"1978","unstructured":"Spieler P, Schmid U. 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Berlin: Springer, 1978."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/32.2.6198355","article-title":"Immunoenzymatic labelling of monoclonal antibodies using immuno complexes of alkaline phosphatase and monoclonal antialkaline phosphatase (APAAP complexes)","volume":"32","author":"Cordell, J.L.; Falini, B.; Erber, W.M.","year":"1984","unstructured":"Cordell JL, Falini B, Erber WM, et al. Immunoenzymatic labelling of monoclonal antibodies using immuno complexes of alkaline phosphatase and monoclonal antialkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984;32:219-29.","journal-title":"J Histochem Cytochem"},{"key":"ref_8","first-page":"1042","article-title":"Immunocytochemical detection of T and B cell populations in routine blood smears","volume":"i:","author":"Erber, W.N.; Pinching, A.J.; Mason, D.Y.","year":"1984","unstructured":"Erber WN, Pinching AJ, Mason DY. Immunocytochemical detection of T and B cell populations in routine blood smears. Lancet 1984;i: 1042-6.","journal-title":"Lancet"},{"key":"ref_9","first-page":"83","article-title":"Histological and immunohistological classification","volume":"25","year":"1987","unstructured":"Histological and immunohistological classification. Scand J Immunol 1987;25: 83-91.","journal-title":"Scand J Immunol"},{"key":"ref_10","first-page":"565","article-title":"NonHodgkin's lymphoma in 90 homosexual men","volume":"311","author":"Ziegler, J.L.; Beckstead, J.A.; Volberding, P.A.","year":"1984","unstructured":"Ziegler JL, Beckstead JA, Volberding PA, et al. NonHodgkin's lymphoma in 90 homosexual men. N Engl J Med 1984;311:565-70.","journal-title":"N Engl J Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1002\/1097-0142(19880601)61:11<2325::AID-CNCR2820611130>3.0.CO;2-0","article-title":"AIDS-related lymphoid neoplasia. The memorial hospital experience","volume":"61","author":"Lowenthal, D.A.; Straus, D.J.; Campell, S.W.; Gold, J.M.; Clarkson, B.D.; Koziner, B.","year":"1988","unstructured":"Lowenthal DA, Straus DJ, Campell SW, Gold JM, Clarkson BD, Koziner B. AIDS-related lymphoid neoplasia. The memorial hospital experience. Cancer 1988;61: 2325-37.","journal-title":"Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1200\/JCO.1987.5.9.1322","article-title":"AIDS-related malignant lymphoma: results of prospective treatment trials","volume":"5","author":"Gill, P.S.; Levine, A.M.; Krailo, M.","year":"1987","unstructured":"Gill PS, Levine AM, Krailo M, et al. AIDS-related malignant lymphoma: results of prospective treatment trials. J Clin Oncol 1987;5:1322-8.","journal-title":"J Clin Oncol"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.7326\/0003-4819-108-1-42","article-title":"Fine-needle aspiration biopsy of patients with acquired immunodeficiency syndrome (AIDS): experience in an outpatient clinic","volume":"108","author":"Bottles, K.; McPaul, L.W.; Volberding, P.","year":"1988","unstructured":"Bottles K, McPaul LW, Volberding P. Fine-needle aspiration biopsy of patients with acquired immunodeficiency syndrome (AIDS): experience in an outpatient clinic. Ann Intern Med 1988;108:42-5.","journal-title":"Ann Intern Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0002-9343(86)90309-8","article-title":"Fine needle aspiration biopsy: has its -time come?","volume":"81","author":"Bottles, K.; Miller, T.R.; Cohen, M.B.; Ljung, B.M.","year":"1986","unstructured":"Bottles K, Miller TR, Cohen MB, Ljung BM. Fine needle aspiration biopsy: has its -time come? 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