{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:42:12Z","timestamp":1761100932957,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:p>Stromal cell numbers from subjects with no haematological disease and those with acute myeloid leukaemia (AML), chronic granulocytic leukaemia (CGL), acute lymphatic leukaemia (ALL) and non-Hodgkin's lymphoma (NHL) were compared to determine their role in malignancy. Frozen sections of trephine biopsy specimens from iliac crests were stained for endogenous alkaline phosphatase activity, endogenous acid phosphatase activity, and, using immunocytochemical methods, for endothelial cells (anti-factor-VIII related antigen) and macrophages and related cells (EBM\/11). In granulocytic malignancies, whether acute or chronic, alkaline phosphatase positive reticulum cells (AL-RC) and vascular endothelial cells were generally increased. In lymphoid malignancies, the numbers of AL-RC were generally reduced. Numbers of vascular endothelial cells seemed to be normal in ALL but reduced in foci of NHL. Macrophages are numerous in normal marrow, and their numbers seemed to be normal in granulocytic lesions but were more variable and sometimes reduced in ALL and NHL. Lymphoid malignancies, therefore, have a destructive effect on some stromal elements; granulocytic malignancies are associated with normal or increased numbers of stromal cells. A possible consequence of depleted stromal cells might be slower reconstitution of normal haemopoiesis after treatment. The large numbers in granulocytic malignancies raises the possibility of synergistic stimulation between stromal and neoplastic cells.<\/jats:p>","DOI":"10.1136\/jcp.43.11.942","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"942-946","source":"Crossref","is-referenced-by-count":26,"title":["Bone marrow stromal cell changes in haematological malignancies."],"prefix":"10.1136","volume":"43","author":[{"given":"S A","family":"Dilly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C J","family":"Jagger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1084\/jem.150.4.919","article-title":"Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors","volume":"150","author":"Westen, H.; Bainton, D.F.","year":"1979","unstructured":"Westen H, Bainton DF. Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors. J Exp Med 1979;150:919-37.","journal-title":"J Exp Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1182\/blood.V66.2.273.273","article-title":"Hematopoietic factor production by a cell line (TC-1) derived from adherent murine marrow cells","volume":"66","year":"1985","unstructured":"Song ZX, Shadduck RK, Innes Jr DJ, Waheed A, Quesenberry PJ. Hematopoietic factor production by a cell line (TC-1) derived from adherent murine marrow cells. Blood 1985;66:273-8 1.","journal-title":"Blood"},{"key":"ref_3","first-page":"137","article-title":"Stromal cell regulation of lymphoid and myeloid differentiation","volume":"13","author":"Quesenberry, P.J.; McNiece, I.K.; Robinson, B.E.","year":"1987","unstructured":"Quesenberry PJ, McNiece IK, Robinson BE, et al. Stromal cell regulation of lymphoid and myeloid differentiation. Blood Cells 1987;13:137-46.","journal-title":"Blood Cells"},{"issue":"3","key":"ref_4","first-page":"83","article-title":"The role ofstromal cells and growth factors in haemopoiesis and modulation of their effects by the src oncogene","volume":"1985","author":"Dexter, T.M.; Whetton, A.D.; Spooncer, E.; Heyworth, C.; Simmons, P.","unstructured":"Dexter TM, Whetton AD, Spooncer E, Heyworth C, Simmons P. The role ofstromal cells and growth factors in haemopoiesis and modulation of their effects by the src oncogene. J Cell Sci 1985;(Suppl 3):83-95.","journal-title":"J Cell Sci"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1136\/jcp.41.5.510","article-title":"Monoclonal antibody EBM\/ 11: high cellular specificity for human macrophages","volume":"41","author":"Kelly, P.M.A.; Bliss, E.; Morton, J.A.; Burns, J.; McGee, J.O.","year":"1988","unstructured":"Kelly PMA, Bliss E, Morton JA, Burns J, McGee JO. Monoclonal antibody EBM\/11: high cellular specificity for human macrophages. J Clin Pathol 1988;41:510-15.","journal-title":"J Clin Pathol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2141.1988.tb04225.x","article-title":"Alkaline phosphatase positive precursors of adipocytes in human bone marrow","volume":"68","author":"Bianco, P.; Constantin, M.; Dearden, L.C.; Bonucci, E.","year":"1988","unstructured":"Bianco P, Constantin M, Dearden LC, Bonucci E. Alkaline phosphatase positive precursors of adipocytes in human bone marrow. Br J Haematol 1988;68:401-3.","journal-title":"Br J Haematol"},{"key":"ref_7","first-page":"1","article-title":"Stromal cell and factor dependent B lymphopoiesis in culture","volume":"135","author":"Kincade, P.W.; Witte, P.L.; Landreth, K.S.","year":"1987","unstructured":"Kincade PW, Witte PL, Landreth KS. Stromal cell and factor dependent B lymphopoiesis in culture. Curr Topics Microbiol Immunol 1987;135:1-21.","journal-title":"Curr Topics Microbiol Immunol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.43.11.942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:28:47Z","timestamp":1758796127000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.43.11.942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":7,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1990,11,1]]},"published-print":{"date-parts":[[1990,11]]}},"alternative-id":["10.1136\/jcp.43.11.942"],"URL":"https:\/\/doi.org\/10.1136\/jcp.43.11.942","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}