{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:38:52Z","timestamp":1775212732123,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1990,5]]},"abstract":"<jats:p>Glomerular filtration rates (GFR) were measured with 51Cr-EDTA in 38 patients (aged 40-75 years) with homozygous sickle cell disease and compared with serum beta 2 microglobulin concentrations in 38 patients and with creatinine clearance in 21 patients. GFR estimated with 51Cr-EDTA was closely correlated with single serum creatinine measurements and the inverse of serum beta 2 microglobulin. Creatinine clearance was also found to be correlated, but values were, on average, 32% below those obtained by the 51Cr-EDTA method, and this difference was significant. It is concluded that measurements of beta 2 microglobulin, single serum creatinine, and creatinine clearance are valuable indicators of GFR in homozygous sickle cell disease. Measurement of beta 2 microglobulin was a useful and reliable method of estimating GFR from single plasma measurements and is therefore a useful means of screening the population.<\/jats:p>","DOI":"10.1136\/jcp.43.5.370","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"370-372","source":"Crossref","is-referenced-by-count":15,"title":["Measurement of glomerular filtration rate in homozygous sickle cell disease: a comparison of 51Cr-EDTA clearance, creatinine clearance, serum creatinine and beta 2 microglobulin."],"prefix":"10.1136","volume":"43","author":[{"given":"S A","family":"Aparicio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mojiminiyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Kay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B J","family":"Shepstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"de Ceulaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G R","family":"Serjeant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/pgmj.54.631.302","article-title":"The assessment of glomerular function: creatinine clearance or plasma creatinine","volume":"54","author":"Morgan, D.B.; Dillon, S.; Payne, R.B.","year":"1978","unstructured":"Morgan DB, Dillon S, Payne RB. 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Br Med J 1981;282:1 181-3.","journal-title":"Br Med J"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000182331","article-title":"2 microglobulin in sickle cell anaemia","volume":"29","author":"de Jong PE; de Jong-van-den Burg LTW; GS, Sewrajsingh","year":"1981","unstructured":"de Jong PE, de Jong-van-den Burg LTW, Sewrajsingh GS et al. 2 microglobulin in sickle cell anaemia. Nephron 1981;29:138-41.","journal-title":"Nephron"},{"key":"ref_9","first-page":"37","article-title":"Sickle cell disease","author":"Serjeant, G.R.","year":"1985","unstructured":"Serjeant GR. Sickle cell disease. Oxford: Oxford University Press, 1985:37-40."},{"issue":"37","key":"ref_10","first-page":"169","article-title":"Glomerular filtration rate measurement in man by the single injection method using \"Cr-EDTA","volume":"1969","author":"Chantler, C.; Garnett, E.S.; Parsons, V.; Veall, N.","unstructured":"Chantler C, Garnett ES, Parsons V, Veall N. Glomerular filtration rate measurement in man by the single injection method using \"Cr-EDTA. Clin Sci 1969;37:169-80.","journal-title":"Clin Sci"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000180203","article-title":"Serum fi2 microglobulin in renal disease","volume":"10","author":"Wibell, L.; Evrin, P.E.; Berggard, I.","year":"1973","unstructured":"Wibell L, Evrin PE, Berggard I. Serum fi2 microglobulin in renal disease. Nephron 1973;10:320-31.","journal-title":"Nephron"},{"key":"ref_12","first-page":"398","article-title":"2 microglobulin and, B2 microglobulin binding proteins in inflammatory diseases","volume":"5","author":"Reveillard, J.P.; Vincent, C.; Clot, J.; Sany, J.","year":"1982","unstructured":"Reveillard JP, Vincent C, Clot J, Sany J. 2 microglobulin and,B2 microglobulin binding proteins in inflammatory diseases. Eur J Rheumatol Inflamm 1982;5:398-405.","journal-title":"Eur J Rheumatol Inflamm"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.43.5.370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:54:29Z","timestamp":1765076069000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.43.5.370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,5]]},"references-count":12,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1990,5,1]]},"published-print":{"date-parts":[[1990,5]]}},"alternative-id":["10.1136\/jcp.43.5.370"],"URL":"https:\/\/doi.org\/10.1136\/jcp.43.5.370","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,5]]}}}