{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:59:48Z","timestamp":1765709988867,"version":"3.48.0"},"reference-count":17,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:p>Silver binding nucleolar regions (AgNORs) were evaluated in normal endocervix, adenocarcinoma, and its potential precursor, adenocarcinoma in situ (AIS), in an attempt to increase an understanding of the natural history of cervical adenocarcinoma and to identify a marker for abnormal endocervical (atypical glandular) cells which could aid diagnosis and follow up of endocervical lesions. For every 50 cells the mean AgNOR counts were as follows: normal endocervical cells (n = 15) 79.8 (95% Cl 68-91); AIS (n = 20) 200.7 (95% Cl 182-219); and invasive adenocarcinoma (n = 30) 299 (271-328). There was no overlap between the groups of normal endocervical cells and invasive adenocarcinoma, but there was significant overlap between cases of invasive adenocarcinoma and carcinoma in situ. In six out of 17 cases with AIS, NOR count in adjacent morphologically normal glandular cells (\"internal\" controls) was increased when compared with the \"external\" (normal endocervical) control group. This suggests the presence of wider field changes not previously identified using routine histological methods. The findings suggest that AIS is a potential premalignant precursor of invasive adenocarcinoma, but that assessment of NORs is of no practical use in discriminating between the histological types of cervical carcinoma.<\/jats:p>","DOI":"10.1136\/jcp.43.8.657","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"657-660","source":"Crossref","is-referenced-by-count":11,"title":["Nucleolar organiser regions in adenocarcinoma in situ and invasive adenocarcinoma of the cervix."],"prefix":"10.1136","volume":"43","author":[{"given":"J F","family":"Darne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S V","family":"Polacarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Sheridan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Ginsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1990,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1136\/bmj.295.6611.1446","article-title":"Cervical adenocarcinoma and oral contraceptives","volume":"295","author":"Chilvers, C.; Mant, D.; Pike, M.C.","year":"1987","unstructured":"Chilvers C, Mant D, Pike MC. Cervical adenocarcinoma and oral contraceptives. Br Med J 1987;295:1446-7.","journal-title":"Br Med J"},{"issue":"49","key":"ref_2","first-page":"596","article-title":"Invasive adenocarcinoma of the uterine cervix","volume":"1977","author":"Gallup, D.G.; Abell, M.R.","unstructured":"Gallup DG, Abell MR. Invasive adenocarcinoma of the uterine cervix. Obstet Gynecol 1977-49:596-602.","journal-title":"Obstet Gynecol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/1097-0142(19850701)56:1<167::AID-CNCR2820560126>3.0.CO;2-T","article-title":"Early stage adenocarcinoma of the uterine cervix","volume":"56","author":"Teshima, S.; Shimosato, Y.; Kishi, K.; Ohmi, K.; Uei, Y.","year":"1985","unstructured":"Teshima S, Shimosato Y, Kishi K, Ohmi K, Uei Y. Early stage adenocarcinoma of the uterine cervix. Cancer 1985;56: 167-72.","journal-title":"Cancer"},{"key":"ref_4","first-page":"975","article-title":"Noninvasive Kingdom cancer registries has shoNwn a threefold increase in cervical adenocarcinoma in 20 to 34 year olds during the 10 years studied.3 There must be a parallel incre:ase in sprqeucaumrosuosr-cleasricoinsnoomfaadeofnoctahrecincoemraviaxnd umteirxi.ed aCdaenncoe-r","volume":"44","author":"Christopherson, W.M.; Nealon, N.; Gray, L.A.","year":"1979","unstructured":"Christopherson WM, Nealon N, Gray LA. Noninvasive Kingdom cancer registries has shoNwn a threefold increase in cervical adenocarcinoma in 20 to 34 year olds during the 10 years studied.3 There must be a parallel incre:ase in sprqeucaumrosuosr-cleasricoinsnoomfaadeofnoctahrecincoemraviaxnd umteirxi.ed aCdaenncoe-r 1979;44:975-83."},{"article-title":"Overtriep SH, Verdouk GW. Adenocarcinoma in situ of the cervix: an underdiagnosed lesion. Cancer 1981; 48: 768-73. AIS in the same age group. Hysterectomy is most undesirable in such young womeri, but diagnostic cone biopsy is thought tLo be therapeutic if the margins of excision-are clear","author":"Boon, M.E.; Baak, J.P.A.; Kurver, P.J.H.","key":"ref_5","unstructured":"Boon ME, Baak JPA, Kurver PJH, Overtriep SH, Verdouk GW. Adenocarcinoma in situ of the cervix: an underdiagnosed lesion. Cancer 1981;48:768-73. AIS in the same age group. Hysterectomy is most undesirable in such young womeri, but diagnostic cone biopsy is thought tLo be therapeutic if the margins of excision-are clear."},{"key":"ref_6","first-page":"885","article-title":"Nucleolar organiser region associated We observed an increase in NOR cou nt in morphologically normal endocervical eepithelium adjacent to AIS in six out of 17 cases. Using the c-myc oncogene mono(clonal antibody P62, similarly abnormal gene exc~pprreess-- sion or amplification was observed in ninie out of 14 cases in otherwise normal glands adjjacent to AIS (personal observations, Polacar2Z SV, Dame JF, Sharp F). These observations iimply a more widespread field change and suiggest protein in cutaneous melanotic lesions: a quantitative study","volume":"40","author":"Crocker, J.; Silbeck, N.","year":"1987","unstructured":"Crocker J, Silbeck N. Nucleolar organiser region associated We observed an increase in NOR cou nt in morphologically normal endocervical eepithelium adjacent to AIS in six out of 17 cases. Using the c-myc oncogene mono(clonal antibody P62, similarly abnormal gene exc~pprreess-- sion or amplification was observed in ninie out of 14 cases in otherwise normal glands adjjacent to AIS (personal observations, Polacar2Z SV, Dame JF, Sharp F). These observations iimply a more widespread field change and suiggest protein in cutaneous melanotic lesions: a quantitative study. J Clin Pathol 1987;40:885-9.","journal-title":"J Clin Pathol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2559.1989.tb02114.x","article-title":"The value of NOR numbers in neoplastic and non-neoplastic epithelium of the stomach","volume":"14","author":"Suarez, V.; Newman, J.; Hiley, C.; Crocker, J.; Collins, M.","year":"1989","unstructured":"Suarez V, Newman J, Hiley C, Crocker J, Collins M. The value of NOR numbers in neoplastic and non-neoplastic epithelium of the stomach. Histopathol 1989;14:61-6.","journal-title":"Histopathol"},{"key":"ref_8","article-title":"HPV infection and nucleolar organiser regions in cervical epithelium. Abstract 80. 156th Meeting of the Pathology society, 1988","author":"Egan, M.; Freeth, M.G.; CIN, Crocker J.","year":"1988","unstructured":"Egan M, Freeth MG, Crocker J. CIN, HPV infection and nucleolar organiser regions in cervical epithelium. Abstract 80. 156th Meeting of the Pathology society, 1988. London: Pathology Society, 1988."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1365-2559.1988.tb01923.x","article-title":"Evaluation of nucleolar regionassociated proteins in breast malignancy","volume":"12","author":"Smith, R.; Crocker, J.","year":"1988","unstructured":"Smith R, Crocker J. Evaluation of nucleolar regionassociated proteins in breast malignancy. Histopathol 1988;12:113-25.","journal-title":"Histopathol"},{"key":"ref_10","first-page":"807","article-title":"Adenocarcinoma in situ of the uterine cervix","volume":"18","author":"Weisbrot, I.M.; Stablinsky, C.; Davis, A.M.","year":"1972","unstructured":"Weisbrot IM, Stablinsky C, Davis AM. Adenocarcinoma in situ of the uterine cervix. Cancer 1972;18:807-10.","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0002-9378(65)90063-3","article-title":"Follow up of patients with adenocarcinoma ofthe cervix and cervical stunp","volume":"93","author":"Peete, C.H.; Carter, B.; Cherry, W.B.","year":"1965","unstructured":"Peete CH, Carter B, Cherry WB, et al. Follow up of patients with adenocarcinoma ofthe cervix and cervical stunp. Am J Obstet Gynecol 1965;93:343-56.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/0090-8258(89)90551-9","article-title":"Predictive value of cone margins and post-cone endocervical curettage with residual disease in subsequent hysterectomy","volume":"33","author":"Husseinzadek, N.; Shbaro, I.; Wesseler, T.","year":"1989","unstructured":"Husseinzadek N, Shbaro I, Wesseler T. 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JPathol 1989;157:307-13.","journal-title":"JPathol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.43.8.657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T10:56:52Z","timestamp":1765709812000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.43.8.657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,8]]},"references-count":17,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1990,8,1]]},"published-print":{"date-parts":[[1990,8]]}},"alternative-id":["10.1136\/jcp.43.8.657"],"URL":"https:\/\/doi.org\/10.1136\/jcp.43.8.657","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1990,8]]}}}