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Smooth muscle antibodies with the V pattern or antinuclear antibodies, mainly of the speckled type, or anti-IMF, occurred in 35 cases, being widely distributed in all groups. Such an autoantibody response resembles the \"viral\" autoimmunity described in various infectious diseases and in particular that of non-A, non-B post-transfusion hepatitis. Autoantibodies may be of some prognostic relevance, as the prevalence of smooth muscle antibodies V increased as the disease progressed (asymptomatic carriers 20%, those with PGL 29%, those with ARC 47%, and those with AIDS 63%. In the PGL group autoantibody positivity correlated with the presence of skin anergy. The fact that autoantibodies were more frequently detected in patients with circulating immune complexes suggests that these can contain autoantibodies and the corresponding autoantigens.<\/jats:p>","DOI":"10.1136\/jcp.44.1.64","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"64-68","source":"Crossref","is-referenced-by-count":16,"title":["Serum non-organ specific autoantibodies in human immunodeficiency virus 1 infection."],"prefix":"10.1136","volume":"44","author":[{"given":"F","family":"Cassani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Baffoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Raise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Selleri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Monti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Bonazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F M","family":"Gritti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F B","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev.iy.03.040185.002401","article-title":"Immunologic abnormalities in the acquired immunodeficiency syndrome","volume":"3","author":"Lane, H.C.; Fauci, A.S.","year":"1985","unstructured":"Lane HC, Fauci AS. 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Ann Intern Med 1987;107:234-42.","journal-title":"Ann Intern Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM198308253090803","article-title":"Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome","volume":"309","author":"Lane, H.C.; Masur, H.; Edgar, L.C.; Whalen, G.; Rook, A.H.; Fauci, A.S.","year":"1983","unstructured":"Lane HC, Masur H, Edgar LC, Whalen G, Rook AH, Fauci AS. Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med 1983;309:453-8.","journal-title":"N Engl J Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2141.1989.tb00259.x","article-title":"Immunochemical analysis of platelet autoantibodies in HIV-related thrombocytopenic purpura: a study of 68 patients","volume":"73","author":"Bettaieb, A.; Oksenhendler, E.; Fromont, P.; Duedari, N.; Bierling, P.","year":"1989","unstructured":"Bettaieb A, Oksenhendler E, Fromont P, Duedari N, Bierling P. Immunochemical analysis of platelet autoantibodies in HIV-related thrombocytopenic purpura: a study of 68 patients. Br J Haematol 1989;73:241-7.","journal-title":"Br J Haematol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0090-1229(89)90061-5","article-title":"Isotype, distribution and target analysis of lymphocyte reactive antibodies in patients with human immunodeficiency virus infection","volume":"53","author":"Silvestris, F.; Edwards, B.S.; Sadeghi, O.M.; Frassanito, M.A.; RC, Jr, Williams; Dammacco, F.","year":"1989","unstructured":"Silvestris F, Edwards BS, Sadeghi OM, Frassanito MA, Williams RC Jr, Dammacco F. Isotype, distribution and target analysis of lymphocyte reactive antibodies in patients with human immunodeficiency virus infection. Clin Immunol Immunopathol 1989;53:329-40.","journal-title":"Clin Immunol Immunopathol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/327710a0","article-title":"An AIDSrelated cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells","volume":"327","author":"Stricker, R.B.; McHugh, T.M.; Moody, D.","year":"1987","unstructured":"Stricker RB, McHugh TM, Moody D, et al. An AIDSrelated cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells. Nature 1987; 327:710-13.","journal-title":"Nature"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1172\/JCI114034","article-title":"Common epytope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals","volume":"83","author":"Golding, H.; Shearer, G.M.; Hillman, K.","year":"1989","unstructured":"Golding H, Shearer GM, Hillman K, et al. Common epytope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals. J Clin Invest 1989;83:1430-5.","journal-title":"J Clin Invest"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/jcp.42.6.629","article-title":"Lupus anticoagulant, anticardiolipin antibodies and human immunodeficiency virus in haemophilia","volume":"42","author":"Cohen, H.; Mackie, I.J.; Anagnostopoulos, N.; Savage, G.F.; Machin, S.J.","year":"1989","unstructured":"Cohen H, Mackie IJ, Anagnostopoulos N, Savage GF, Machin SJ. Lupus anticoagulant, anticardiolipin antibodies and human immunodeficiency virus in haemophilia. J Clin Pathol 1989;42:629-33.","journal-title":"J Clin Pathol"},{"key":"ref_9","first-page":"3346","article-title":"Antibodies to CD4 in individuals infected with human immunodeficiency","volume-title":"virus type 1. Proc Natl Acad Sci","volume":"86","author":"Kowalsky, M.; Ardman, B.; Basiripour, L.","year":"1989","unstructured":"Kowalsky M, Ardman B, Basiripour L, et al. Antibodies to CD4 in individuals infected with human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1989;86:3346-50."},{"key":"ref_10","first-page":"611","article-title":"Individuals infected with HIV possess antibodies against IL-2","volume":"65","author":"Bost, K.L.; Hahn, B.H.; Saag, M.S.; Shaw, G.M.; Weigent, D.A.; Blalock, J.E.","year":"1988","unstructured":"Bost KL, Hahn BH, Saag MS, Shaw GM, Weigent DA, Blalock JE. Individuals infected with HIV possess antibodies against IL-2. Immunology 1988;65:611-5.","journal-title":"Immunology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7326\/0003-4819-106-1-19","article-title":"The co-occurrence of Reiter's syndrome and acquired immunodeficiency","volume":"106","author":"Wichester, R.; Bernstein, D.H.; Fischer, H.D.; Enlow, R.; Solomon, G.","year":"1987","unstructured":"Wichester R, Bernstein DH, Fischer HD, Enlow R, Solomon G. The co-occurrence of Reiter's syndrome and acquired immunodeficiency. Ann Intern Med 1987; 106:19-26.","journal-title":"Ann Intern Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0272-2712(18)30683-8","article-title":"Autoimmune manifestations of human immunodeficiency virus (HIV) infection","volume":"8","author":"Calabrese, L.H.","year":"1988","unstructured":"Calabrese LH. Autoimmune manifestations of human immunodeficiency virus (HIV) infection. Clin Lab Med 1988;8:269-79.","journal-title":"Clin Lab Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF00915154","article-title":"Acquired immune deficiency syndrome (AIDS) and autoimmunity-Mutually exclusive entities?","volume":"8","author":"Solinger, A.M.; Adams, L.E.; Friedman-Kien, A.E.; Hess, E.V.","year":"1988","unstructured":"Solinger AM, Adams LE, Friedman-Kien AE, Hess EV. Acquired immune deficiency syndrome (AIDS) and autoimmunity-Mutually exclusive entities? J Clin Immunol 1988;8:32-42.","journal-title":"J Clin Immunol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.7326\/0003-4819-105-2-234","article-title":"Centers for Disease Control. Classification system for human T-lymphotropic virus type III\/lymphadenopathy-associated virus infections","volume":"105","year":"1986","unstructured":"Centers for Disease Control. Classification system for human T-lymphotropic virus type III\/lymphadenopathy-associated virus infections. Ann Intern Med 1986;105:234-7.","journal-title":"Ann Intern Med"},{"key":"ref_15","article-title":"Manual of autoimmune serology","author":"Roitt, I.M.; Doniach, D.","year":"1969","unstructured":"Roitt IM, Doniach D. Manual of autoimmune serology. Geneva: World Health Organization, 1969."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/jcp.29.5.403","article-title":"Classification of smooth muscle autoantibodies (SMA) detected by immunofluorescence","volume":"29","author":"Bottazzo, G.F.; Florin-Christensen, A.; Fairfax, A.; Swana, G.; Doniach, D.; Groeschel-Stewart, U.","year":"1976","unstructured":"Bottazzo GF, Florin-Christensen A, Fairfax A, Swana G, Doniach D, Groeschel-Stewart U. Classification of smooth muscle autoantibodies (SMA) detected by immunofluorescence. J Clin Pathol 1976;29:403-10.","journal-title":"J Clin Pathol"},{"key":"ref_17","first-page":"43","article-title":"Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis. Clin Exp Immunol","volume":"48","author":"Bernstein, R.M.; Steigerwald, J.C.; Tan, E.M.","year":"1982","unstructured":"Bernstein RM, Steigerwald JC, Tan EM. Association of antinuclear and antinucleolar antibodies in progressive systemic sclerosis. Clin Exp Immunol 1982;48:43-51."},{"key":"ref_18","first-page":"588","article-title":"Precipitating antibodies to rabbit thymus extractable antigens in chronic liver disease: relationship with anti-actin antibodies. Clin Exp Immunol","volume":"68","author":"Cassani, F.; Fusconi, M.; Bianchi, F.B.","year":"1987","unstructured":"Cassani F, Fusconi M, Bianchi FB, et al. Precipitating antibodies to rabbit thymus extractable antigens in chronic liver disease: relationship with anti-actin antibodies. Clin Exp Immunol 1987;68:588-95."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2776(08)60836-6","article-title":"Autoantibodies to nuclear antigens: their immunobiology and medicine","volume":"33","author":"Tan, E.M.","year":"1982","unstructured":"Tan EM. Autoantibodies to nuclear antigens: their immunobiology and medicine. Adv Immunol 1982;33:167-240.","journal-title":"Adv Immunol"},{"key":"ref_20","first-page":"801","article-title":"Immunomorphological characterisation of antinuclear antibodies in chronic liver disease","volume":"8","author":"Cassani, F.; Bianchi, F.B.; Lenzi, M.; Volta, U.; Pisi, E.","year":"1985","unstructured":"Cassani F, Bianchi FB, Lenzi M, Volta U, Pisi E. Immunomorphological characterisation of antinuclear antibodies in chronic liver disease. J Clin Pathol 1985;8:801-5.","journal-title":"J Clin Pathol"},{"key":"ref_21","first-page":"621","article-title":"Smooth muscle autoantibodies and autoantigens. Clin Exp Immunol","volume":"38","author":"Toh, B.H.","year":"1979","unstructured":"Toh BH. Smooth muscle autoantibodies and autoantigens. Clin Exp Immunol 1979;38:621-8."},{"key":"ref_22","first-page":"76","article-title":"Viral infections and IgM autoantibodies to cytoplasmic intermediate filaments. Clin Exp Immunol","volume":"37","author":"Toh, B.H.; Yildiz, A.; Sotelo, J.","year":"1979","unstructured":"Toh BH, Yildiz A, Sotelo J, et al. Viral infections and IgM autoantibodies to cytoplasmic intermediate filaments. Clin Exp Immunol 1979;37:76-82."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0090-1229(81)90204-X","article-title":"Autoantibody to intermediate filaments in viral hepatitis","volume":"21","author":"Pedersen, J.S.; Toh, H.; Locarnini, S.A.; Gust, I.D.; Shyamala, G.N.","year":"1981","unstructured":"Pedersen JS, Toh H, Locarnini SA, Gust ID, Shyamala GN. Autoantibody to intermediate filaments in viral hepatitis. Clin Immunol Immunopathol 1981;21:154-61.","journal-title":"Clin Immunol Immunopathol"},{"key":"ref_24","first-page":"7","article-title":"IgM autoantibody to intermediate filaments in infectious mononucleosis","volume":"5","author":"Bretherton, L.; Toh, B.H.","year":"1981","unstructured":"Bretherton L, Toh BH. IgM autoantibody to intermediate filaments in infectious mononucleosis. J Clin Lab Immunol 1981;5:7-10.","journal-title":"J Clin Lab Immunol"},{"key":"ref_25","first-page":"527","article-title":"Segregation of autoantibody to cytoskeletal filaments, actin and intermediate tilaments, with two types of chronic active hepatitis. Clin Exp Immunol","volume":"48","author":"Pedersen, J.S.; Toh, B.H.; Mackay, I.R.","year":"1982","unstructured":"Pedersen JS, Toh BH, Mackay IR, et al. Segregation of autoantibody to cytoskeletal filaments, actin and intermediate tilaments, with two types of chronic active hepatitis. Clin Exp Immunol 1982;48:527-32."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/jcp.39.8.897","article-title":"Autoimmunity in chronic liver disease caused by hepatitis delta virus","volume":"39","author":"Zauli, D.; Crespi, C.; Bianchi, F.B.; Craxi', A.; Pisi, E.","year":"1986","unstructured":"Zauli D, Crespi C, Bianchi FB, Craxi' A, Pisi E. Autoimmunity in chronic liver disease caused by hepatitis delta virus. J Clin Pathol 1986;39:897-9.","journal-title":"J Clin Pathol"},{"key":"ref_27","first-page":"1","article-title":"Autoantibodies to intermediate filaments in acute viral hepatitis A, B and non-A, non-B are directed against vimentin","volume":"19","author":"Brown, C.; Pedersen, J.S.; Underwood, JR, Gust; ID, Toh; B.H.","year":"1986","unstructured":"Brown C, Pedersen JS, Underwood JR, Gust ID, Toh BH. Autoantibodies to intermediate filaments in acute viral hepatitis A, B and non-A, non-B are directed against vimentin. J Clin Lab Immunol 1986;19:1-4.","journal-title":"J Clin Lab Immunol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1172\/JCI110500","article-title":"Immunoglobulin M autoantibody to vimentin intermediate filaments","volume":"69","author":"Senecal, J.L.; Rothfield, N.F.; Oliver, J.M.","year":"1982","unstructured":"Senecal JL, Rothfield NF, Oliver JM. Immunoglobulin M autoantibody to vimentin intermediate filaments. J Clin Invest 1982;69:716-21.","journal-title":"J Clin Invest"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0092-8674(81)90383-4","article-title":"All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody","volume":"27","author":"Pruss, R.M.; Mirsky, R.; Raff, M.C.; Thorpe, R.; Dowding, A.J.; Anderton, B.H.","year":"1981","unstructured":"Pruss RM, Mirsky R, Raff MC, Thorpe R, Dowding AJ, Anderton BH. All classes of intermediate filaments share a common antigenic determinant defined by a monoclonal antibody. Cell 1981;27:419-28.","journal-title":"Cell"},{"key":"ref_30","first-page":"171","article-title":"Markers of \"viral\" autoimmunity in chronic non-A, non-B post-transfusion hepatitis","volume":"20","author":"Cassani, F.; Tremolada, F.; Baffoni, L.","year":"1988","unstructured":"Cassani F, Tremolada F, Baffoni L, et al. Markers of \"viral\" autoimmunity in chronic non-A, non-B post-transfusion hepatitis. Ital J Gastroenterol 1988;20:171-4.","journal-title":"Ital J Gastroenterol"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.2496467","article-title":"An assay for circulating antibodies to a major etiologic virus ofhuman non-A, nonB hepatitis","volume":"244","author":"Kuo, G.; Choo, Q.L.; Alter, J.H.","year":"1989","unstructured":"Kuo G, Choo QL, Alter JH, et al. An assay for circulating antibodies to a major etiologic virus ofhuman non-A, nonB hepatitis. Science 1989;244:362-4.","journal-title":"Science"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.3016902","article-title":"Direct polyclonal activation of human B lymphocytes by the acquired immunodeficiency syndrome virus","volume":"233","author":"Schnittman, S.M.; Lane, H.C.; Higgins, S.E.; Folks, T.; Fauci, A.S.","year":"1986","unstructured":"Schnittman SM, Lane HC, Higgins SE, Folks T, Fauci AS. Direct polyclonal activation of human B lymphocytes by the acquired immunodeficiency syndrome virus. Science 1986;233: 1084-6.","journal-title":"Science"},{"key":"ref_33","first-page":"439","article-title":"Mechanisms of B cell activation in patients with acquired immunodeficiency syndrome and related disorders","volume":"78","author":"Yarchoan, R.; Redfield, R.R.; Broder, S.","year":"1986","unstructured":"Yarchoan R, Redfield RR, Broder S. Mechanisms of B cell activation in patients with acquired immunodeficiency syndrome and related disorders. J Clin Invest 1986; 78:439-47.","journal-title":"J Clin Invest"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0165-2478(82)90135-3","article-title":"Holborow EJ. In vitro induction of anti-intermediate filament antibody in lymphocyte cultures by Epstein-Barr virus","volume":"5","author":"Mortazavi-Milani, S.M.; Stierle, H.E.","year":"1982","unstructured":"Mortazavi-Milani SM, Stierle HE, Holborow EJ. In vitro induction of anti-intermediate filament antibody in lymphocyte cultures by Epstein-Barr virus. Immunol Lett 1982;5:203-5.","journal-title":"Immunol Lett"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0090-1229(86)90091-7","article-title":"Epstein-Barr virus-transformed lymphocytes from patients with bullous diseases produce autoantibodies to cytokeratins","volume":"39","author":"Viac, J.; Paire, J.; Desgranges, C.; Iwatsuki, K.; Thivolet, J.","year":"1986","unstructured":"Viac J, Paire J, Desgranges C, Iwatsuki K, Thivolet J. Epstein-Barr virus-transformed lymphocytes from patients with bullous diseases produce autoantibodies to cytokeratins. Clin Immunol Immunopathol 1986;39: 277-84.","journal-title":"Clin Immunol Immunopathol"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1073\/pnas.80.8.2346","article-title":"Molecular mimicry in virus infection: cross-reaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments","volume":"80","author":"Fujinami, R.S.; Oldstone, M.B.A.; Wroblewska, Z.; Frankel, M.E.; Koprowski, H.","year":"1983","unstructured":"Fujinami RS, Oldstone MBA, Wroblewska Z, Frankel ME, Koprowski H. Molecular mimicry in virus infection: cross-reaction of measles virus phosphoprotein or of herpes simplex virus protein with human intermediate filaments. Proc Natl Acad Sci USA 1983;80:2346-50.","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0090-1229(86)90196-0","article-title":"Circulating immune complexes in patients with acquired immune deficiency syndrome contain the AIDSassociated retrovirus","volume":"40","author":"Morrow, W.J.W.; Wharton, M.; Stricker, R.B.; Levy, J.A.","year":"1986","unstructured":"Morrow WJW, Wharton M, Stricker RB, Levy JA. Circulating immune complexes in patients with acquired immune deficiency syndrome contain the AIDSassociated retrovirus. 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