{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:40:02Z","timestamp":1758908402354,"version":"3.44.0"},"reference-count":7,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:p>Immunohistochemistry with monoclonal antibodies to the T cell receptor V beta regions 5, 6, 8 and 12 was used to determine whether normal intestinal lymphocytes that are potentially exposed to many bacterially derived superantigens show any preferential expression of particular V beta regions compared with the blood. No difference between V beta expression in the mucosa and the blood was observed, suggesting that they share a common pool of alpha beta T cells and that there is no expansion of alpha beta T cells in response to bacterial \"superantigens\" in the gut. The T cell receptor V beta expressed by the activated T cells in the lamina propria of bowel from patients with Crohn's disease was also studied. There was no increase in V beta 8 expression in these cells, suggesting that the increase in V beta 8 observed in the blood and mesenteric nodes of patients with Crohn's disease is not of primary importance in the aetiology of the disease. Finally, V beta expression by mucosal T cells in coeliac disease was studied. There was no difference in V beta use by T cells in coeliac disease and those in the blood and normal jejunum.<\/jats:p>","DOI":"10.1136\/jcp.44.11.915","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"915-918","source":"Crossref","is-referenced-by-count":15,"title":["T cell receptor V beta expression by mucosal T cells."],"prefix":"10.1136","volume":"44","author":[{"given":"J","family":"Spencer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Y","family":"Choy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T T","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0092-8674(89)90980-X","article-title":"B-specific superantigen Staphylococcal Enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice","volume":"56","author":"White, J.; Herman, A.; Pullen, A.M.; Kubo, R.; Kappler, J.W.; The, Marrack P.; V.","year":"1989","unstructured":"White J, Herman A, Pullen AM, Kubo R, Kappler JW, Marrack P. The V,B-specific superantigen Staphylococcal Enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell 1989;56:27-35.","journal-title":"Cell"},{"key":"ref_2","first-page":"81","article-title":"VP specific stimulation of human T cells by staphylococcal toxins","volume":"224","author":"Kappler, J.W.; Kotzin, B.; Herron, L.","year":"1989","unstructured":"Kappler JW, Kotzin B, Herron L, et al. VP specific stimulation of human T cells by staphylococcal toxins. Science 1989;224:81 1-13.","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/345344a0","article-title":"Limited heterogeneity ofrearranged T cell receptor Va transcripts in brains of multiple sclerosis patients","volume":"345","author":"Oksenberg, JR, Stuart; S, Begovich; A.B.","year":"1990","unstructured":"Oksenberg JR, Stuart S, Begovich AB, et al. Limited heterogeneity ofrearranged T cell receptor Va transcripts in brains of multiple sclerosis patients. Nature 1990; 345:344-6.","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1136\/gut.31.12.1365","article-title":"Differential expression ofCD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis","volume":"31","author":"Choy, M.Y.; Walker-Smith, J.A.; Williams, C.B.; MacDonald, T.T.","year":"1990","unstructured":"Choy MY, Walker-Smith JA, Williams CB, MacDonald TT. Differential expression ofCD25 (interleukin-2 receptor) on lamina propria T cells and macrophages in the intestinal lesions in Crohn's disease and ulcerative colitis. Gut 1990;31:1365-70.","journal-title":"Gut"},{"key":"ref_5","first-page":"371","article-title":"Coelic disease","volume-title":"Immunopathology of the small intestine","author":"Marsh, M.N.","year":"1987","unstructured":"Marsh MN. Coelic disease. In: Marsh MN, ed. Immunopathology of the small intestine. Chichester: John Wiley and sons. 1987:371-99."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1136\/adc.65.8.909","article-title":"Revised criteria for the diagnosis of coeliac disease","volume":"65","author":"Walker-Smith, J.A.; Guandalini, S.; Schmitz, J.; Schmerling, D.H.; Visakorpi, J.K.","year":"1990","unstructured":"Walker-Smith JA, Guandalini S, Schmitz J, Schmerling DH, Visakorpi JK. Revised criteria for the diagnosis of coeliac disease. Arch Dis Child 1990;65:909.","journal-title":"Arch Dis Child"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/eji.1830190728","article-title":"Expression of disulphide-linked and non-disulphide-linked forms of the yv heterodimer in human intestinal intraepithelial lymphocytes","volume":"19","author":"Spencer, J.; Isaacson, P.G.; Diss, T.C.; MacDonald, T.T.","year":"1989","unstructured":"Spencer J, Isaacson PG, Diss TC, MacDonald TT. Expression of disulphide-linked and non-disulphide-linked forms of the yv heterodimer in human intestinal intraepithelial lymphocytes. Eur J Immunol 1989;19:1335-8.","journal-title":"Eur J Immunol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.44.11.915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:13:25Z","timestamp":1758906805000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.44.11.915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":7,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1991,11,1]]},"published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1136\/jcp.44.11.915"],"URL":"https:\/\/doi.org\/10.1136\/jcp.44.11.915","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[1991,11]]}}}