{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T09:35:39Z","timestamp":1765704939520,"version":"3.48.0"},"reference-count":32,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:p>In seven of 12 cases of Ber-H2 (Ki-1) positive anaplastic large cell non-Hodgkin's lymphoma (Ki-1 ALCL) disease remained localised to skin, and in five there was extracutaneous spread. Four patients had histological evidence of pre-existing or coexisting mycosis fungoides, and three patients had a long standing history of eczema or ichthyosis. In two cases the presence of a T phenotype was shown in frozen sections, and in a further six cases a T phenotype was firmly established in paraffin wax sections. Four patients died less than one year after presentation (two with disseminated lymphoma; two from other causes); one died at five years with widespread lymphoma and the remaining seven cases were alive one to 14 1\/2 years after presentation. Three of the four patients with associated mycosis fungoides had prolonged survival, contrary to the findings of previous reports which suggest secondary Ki-1 ALCL behaves aggressively. The recognition of these tumours is important because of their relatively good prognosis. The diagnosis can be readily substantiated immunohistochemically, using a simple panel of antibodies.<\/jats:p>","DOI":"10.1136\/jcp.44.2.119","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"119-125","source":"Crossref","is-referenced-by-count":69,"title":["Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin."],"prefix":"10.1136","volume":"44","author":[{"given":"S S","family":"Banerjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Heald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2559.1990.tb01151.x","article-title":"The diagnostic significance of the CD30(Ki-1) antigen","volume":"16","author":"Pallesen, G.","year":"1990","unstructured":"Pallesen G. The diagnostic significance of the CD30(Ki-1) antigen. Histopathology 1990;16:409-13.","journal-title":"Histopathology"},{"key":"ref_2","first-page":"995","article-title":"Histopathology and the diagnosis of mycosis fungoides was confirmed by biopsy; staining for Ki-I antigen with Ber-H2 was negative in all these biopsy specimens. The clinical importance of the association with eczema or ichthyosis is uncertain, but the relation of Ki-I ALCL with mycosis fungoides has been previously recorimmunohistochemistry of peripheral T cell lymphomas: a proposal for their classification","volume":"40","author":"Suchi, T.; Lennert, K.; Tu, L.-Y.","year":"1987","unstructured":"Suchi T, Lennert K, Tu L-Y, et al. Histopathology and the diagnosis of mycosis fungoides was confirmed by biopsy; staining for Ki-I antigen with Ber-H2 was negative in all these biopsy specimens. The clinical importance of the association with eczema or ichthyosis is uncertain, but the relation of Ki-I ALCL with mycosis fungoides has been previously recorimmunohistochemistry of peripheral T cell lymphomas: a proposal for their classification. J Clin Pathol 1987; 40:995-1015.","journal-title":"J Clin Pathol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00000478-198804000-00002","article-title":"Ki-I positive large cell lymphoma: A morphologic and immunologic study of 19 cases","volume":"12","author":"Agnarsson, B.A.; Kadin, M.E.","year":"1988","unstructured":"Agnarsson BA, Kadin ME. Ki-I positive large cell lymphoma: A morphologic and immunologic study of 19 cases. Am JSurg Pathol 1988;12:264-74.","journal-title":"Am JSurg Pathol"},{"issue":"1","key":"ref_4","first-page":"1","article-title":"Anaplastic large cell Ki-I lymphoma. Delineation of two morphological types","volume":"15","author":"Chan, J.K.C.; Ng, C.S.; Hui, P.K.","year":"1989","unstructured":"Chan JKC, Ng CS, Hui PK, et al. Anaplastic large cell Ki-I lymphoma. Delineation of two morphological types. Histopathology 1989;15:1 1-34.","journal-title":"Histopathology"},{"key":"ref_5","first-page":"59","article-title":"Coexpression of epithelial membrane antigen (EMA), Ki-1, and interded6 1443 and has been referred to as secondary Ki-llymphoma.'4 It has been suggested that leukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis","volume":"130","author":"Delsol, G.; AlSaati, T.; Gatter, K.C.","year":"1988","unstructured":"Delsol G, AlSaati T, Gatter KC, et al. Coexpression of epithelial membrane antigen (EMA), Ki-1, and interded6 1443 and has been referred to as secondary Ki-llymphoma.'4 It has been suggested that leukin-2 receptor by anaplastic large cell lymphomas. Diagnostic value in so-called malignant histiocytosis. Am JPathol 1988;130:59-70. such transformed cases behave aggressively with rapid systemic progression,'443 but our","journal-title":"Am JPathol; such transformed cases behave aggressively with rapid systemic progression,'443 but our"},{"article-title":"Clinicopathological study ofKi-1positive lymphomas. Pathol Res Pract 1989; 185: 461-7. experience is different; two of our four cases were alive without dissemination at 87 and 174","author":"Tashiro, K.; Kikuchi, M.; Takeshita, M.; Yoshida, T.; Ohshima, K.","key":"ref_6","unstructured":"Tashiro K, Kikuchi M, Takeshita M, Yoshida T, Ohshima K. Clinicopathological study ofKi-1positive lymphomas. Pathol Res Pract 1989;185:461-7. experience is different; two of our four cases were alive without dissemination at 87 and 174"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1182\/blood.V68.5.1042.1042","article-title":"Childhood Ki-1 lymphoma presenting with skin lesions and peripheral lymphadenopathy","volume":"68","author":"Kadin, M.E.; Sako, D.; Berliner, N.","year":"1986","unstructured":"Kadin ME, Sako D, Berliner N, et al. Childhood Ki-1 lymphoma presenting with skin lesions and peripheral lymphadenopathy. Blood 1986;68:1042-9.","journal-title":"Blood"},{"key":"ref_8","first-page":"359","article-title":"Primary and secondary cutaneous Ki-1+ (CD30+) anaplastic large cell lymphomas. Morphologic, immunohistologic, and clinical characteristics","volume":"135","author":"Kaudewitz, P.; Stein, H.; Dallenbach, F.","year":"1989","unstructured":"Kaudewitz P, Stein H, Dallenbach F, et al. 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