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The second group consisted of 74 cases with histological types known to have a good prognosis, including mucinous, alveolar variant of invasive lobular, medullary, tubular, cribriform and papillary carcinomas. Fifteen (20%) tumours of the first group were positive with the two antibodies. Fourteen of these were of the ductal type and one was a mixed invasive ductal and lobular carcinoma. Ten of the pure ductal cases had areas of comedo carcinoma. The intraductal elements in a further tumour were positively stained with 21N antibody only. None of the second group of tumours, which included histological types known to have good prognosis, stained with 4D5, although one mucinous carcinoma was positively stained with 21N. These findings suggest that in invasive breast carcinoma immunostaining for c-erbB-2 is mainly seen in a subgroup of ductal tumours, and that almost all other histological types, especially those associated with good prognosis, lack this expression.<\/jats:p>","DOI":"10.1136\/jcp.44.3.211","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"211-214","source":"Crossref","is-referenced-by-count":61,"title":["c-erbB-2 expression in different histological types of invasive breast carcinoma."],"prefix":"10.1136","volume":"44","author":[{"given":"S","family":"Soomro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Shousha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Feldmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/312513a0","article-title":"The neuoncogene: an erbB related gene encoding a 185,000 M tumour antigen","volume":"312","author":"Schechter, A.L.; Stern, D.F.; Vaidyanathen, L.","year":"1984","unstructured":"Schechter AL, Stern DF, Vaidyanathen L, et al. 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Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor receptor. Nature 1986;319:230-4.","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1126\/science.3012781","article-title":"The product of the human c-erbB-2 gene: A 185kilodalton glycoprotein with tyrosine kinase activity","volume":"232","author":"Akiyama, T.; Sudo, C.; Ogawara, H.; Toyoshima, K.; Yamamoto, T.","year":"1986","unstructured":"Akiyama T, Sudo C, Ogawara H, Toyoshima K, Yamamoto T. The product of the human c-erbB-2 gene: A 185kilodalton glycoprotein with tyrosine kinase activity. 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Science 1987;237: 178-82.","journal-title":"Science"},{"key":"ref_7","first-page":"765","article-title":"Amplification of c-erbB-2 in human adenocarcinomas in vivo","volume":"i:","author":"Yokota, J.; Yamamoto, T.; Toyoshima, K.","year":"1986","unstructured":"Yokota J, Yamamoto T, Toyoshima K, et al. Amplification of c-erbB-2 in human adenocarcinomas in vivo. Lancet 1986;i:765-7.","journal-title":"Lancet"},{"key":"ref_8","first-page":"69","article-title":"Overexpression of the c-erb B-2 oncoprotein in human breast carcinomas: immunohistological assessment correlates with gene amplification","volume":"ii:","author":"Venter, D.J.; Tuzi, N.L.; Kumar, S.; Gullick, W.J.","year":"1987","unstructured":"Venter DJ, Tuzi NL, Kumar S, Gullick WJ. Overexpression of the c-erb B-2 oncoprotein in human breast carcinomas: immunohistological assessment correlates with gene amplification. Lancet 1987;ii:69-72.","journal-title":"Lancet"},{"key":"ref_9","first-page":"1239","article-title":"Neu-protein overexpression in breast cancer. Association with comedotype ductal carcinoma in situ and limited prognostic value in stage II breast cancer. NEngl JMed","volume":"319","author":"de Vijver MD, Van; JL, Peterse; WJ, Mooi","year":"1988","unstructured":"Van de Vijver MD, Peterse JL, Mooi WJ, et al. Neu-protein overexpression in breast cancer. Association with comedotype ductal carcinoma in situ and limited prognostic value in stage II breast cancer. NEngl JMed 1988;319:1239-45."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/path.1711580204","article-title":"An immunohistochemical and in situ hybridisation study of c-myc and c-erbB-2 expression in primary human breast carcinomas","volume":"158","author":"Walker, R.A.; Senior, P.V.; Jones, J.L.; Critchley, D.R.; Varley, J.M.","year":"1989","unstructured":"Walker RA, Senior PV, Jones JL, Critchley DR, Varley JM. An immunohistochemical and in situ hybridisation study of c-myc and c-erbB-2 expression in primary human breast carcinomas. JPathol 1989;158:97-105.","journal-title":"JPathol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1126\/science.2470152","article-title":"Studies of the HER-2\/neu proto-oncogene in human breast and ovarian cancer","volume":"244","author":"Slamon, D.J.; Godolphin, W.; Jones, L.A.","year":"1989","unstructured":"Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2\/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244: 707-12.","journal-title":"Science"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/bjc.1990.9","article-title":"C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification with prognosis","volume":"61","author":"Parkes, H.C.; Lillycrop, K.; Howell, A.; Craig, R.K.","year":"1990","unstructured":"Parkes HC, Lillycrop K, Howell A, Craig RK. C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification with prognosis. Br J Cancer 1990;61:39-45.","journal-title":"Br J Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.3798106","article-title":"Human breast cancer: correlation of relapse and survival with amplification of the HER-2\/neu oncogene","volume":"235","author":"Slamon, D.J.; Clark, G.M.; Wong, S.G.; Levin, W.J.; Ullrich, A.; McGuire, W.J.","year":"1987","unstructured":"Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WJ. Human breast cancer: correlation of relapse and survival with amplification of the HER-2\/neu oncogene. 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Br J Cancer 1988;58:453-7.","journal-title":"Br J Cancer"},{"key":"ref_16","first-page":"1389","article-title":"Proto-oncogene amplification and human breast tumor phenotype","volume":"4","author":"Adnane, J.; Gaudray, P.; Simon, M.-P.; Simony-Lafontaine, J.; Jeanteur, P.; Theillet, C.","year":"1989","unstructured":"Adnane J, Gaudray P, Simon M-P, Simony-Lafontaine J, Jeanteur P, Theillet C. Proto-oncogene amplification and human breast tumor phenotype. Oncogene 1989;4: 1389-95.","journal-title":"Oncogene"},{"key":"ref_17","first-page":"42619","article-title":"An evaluation of immunoreactivity for c-erbB-2 protein as a marker ofpoor short-term prognosis in breast cancer","volume":"60","author":"Walker, R.A.; Gullick, W.J.; Varley, J.M.","year":"1989","unstructured":"Walker RA, Gullick WJ, Varley JM. An evaluation of immunoreactivity for c-erbB-2 protein as a marker ofpoor short-term prognosis in breast cancer. Br I Cancer 1989;60:42619.","journal-title":"Br I Cancer"},{"key":"ref_18","first-page":"109","article-title":"HER-2 amplification, steroid receptors and epidermal growth factor receptor in primary breast cancer","volume":"4","author":"Zeillinger, R.; Kury, F.; Czerwnka, K.","year":"1989","unstructured":"Zeillinger R, Kury F, Czerwnka K, et al. HER-2 amplification, steroid receptors and epidermal growth factor receptor in primary breast cancer. Oncogene 1989;4:109-14.","journal-title":"Oncogene"},{"key":"ref_19","first-page":"105","article-title":"Proto-oncogene abnormalities in human breast cancer: c-ERBB-2 amplification does not correlate with recurrence of disease","volume":"4","author":"Zhou, D.-J.; Ahuja, H.; Cline, M.J.","year":"1989","unstructured":"Zhou D-J, Ahuja H, Cline MJ. Proto-oncogene abnormalities in human breast cancer: c-ERBB-2 amplification does not correlate with recurrence of disease. Oncogene 1989;4:105-8.","journal-title":"Oncogene"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1200\/JCO.1990.8.1.103","article-title":"Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erb B-2 protein overexpression in primary breast cancer","volume":"8","author":"Paik, S.; Hazan, R.; Fisher, E.R.","year":"1990","unstructured":"Paik S, Hazan R, Fisher ER, et al. Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erb B-2 protein overexpression in primary breast cancer. J Clin Oncol 1990;8:103-12.","journal-title":"J Clin Oncol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1200\/JCO.1987.5.7.999","article-title":"Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease","volume":"5","author":"Cline, M.J.; Battifora, H.; Yokota, J.","year":"1987","unstructured":"Cline MJ, Battifora H, Yokota J. Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease. J Clin Oncol 1987;5:999-1006.","journal-title":"J Clin Oncol"},{"key":"ref_22","first-page":"423","article-title":"Alterations to either c-erbB-2 (neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis","volume":"1","author":"Varley, J.M.; Swallow, J.E.; Brammar, W.J.; Whittaker, J.L.; Walker, R.A.","year":"1987","unstructured":"Varley JM, Swallow JE, Brammar WJ, Whittaker JL, Walker RA. Alterations to either c-erbB-2 (neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis. Oncogene 1987;1:423-30.","journal-title":"Oncogene"},{"key":"ref_23","first-page":"6123","article-title":"Association of multiple copies of the c-erbB-2 oncogen with spread of breast carcinoma","volume":"47","author":"Zhou, D.; Battifora, H.; Yokota, J.; Yamamoto, T.; Cline, M.J.","year":"1987","unstructured":"Zhou D, Battifora H, Yokota J, Yamamoto T, Cline MJ. Association of multiple copies of the c-erbB-2 oncogen with spread of breast carcinoma. Cancer Res 1987; 47:6123-5.","journal-title":"Cancer Res"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1200\/JCO.1989.7.8.1120","article-title":"HER-2\/neu oncogene protein and prognosis in breast cancer","volume":"7","author":"Tandon, A.K.; Clark, G.M.; Chamness, G.C.; Ullrich, A.; McGuire, W.L.","year":"1989","unstructured":"Tandon AK, Clark GM, Chamness GC, Ullrich A, McGuire WL. HER-2\/neu oncogene protein and prognosis in breast cancer. J Clin Oncol 1989;7:1120-8.","journal-title":"J Clin Oncol"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/ijc.2910450112","article-title":"The neu-oncogene protein as a predictive factor for haematogenous metastases in breast cancer patients","volume":"45","author":"C, De Potter; C, Beghin; AP, Makar; D, Vandekerckhove; HJ, Roels","year":"1990","unstructured":"De Potter C, Beghin C, Makar AP, Vandekerckhove D, Roels HJ. The neu-oncogene protein as a predictive factor for haematogenous metastases in breast cancer patients. Int J Cancer 1990;45:55-8.","journal-title":"Int J Cancer"},{"key":"ref_26","article-title":"Tumours of the breast. Fascicle 2. In: Atlas of tumor pathology. Second series","author":"McDivitt, R.W.; Stewart, F.W.; Berg, J.W.","unstructured":"McDivitt RW, Stewart FW, Berg JW. Tumours of the breast. Fascicle 2. In: Atlas of tumor pathology. Second series. Washington, DC: Armed Forces Institute of Pathology, 1968:86."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ajcp\/85.1.1","article-title":"Alveolar variant of invasive lobular carcinoma of the breast. A tumor rich in estrogen receptors","volume":"85","author":"Shousha, S.; Backhous, C.M.; Alaghband-Zadeh, J.; Burn, I.","year":"1986","unstructured":"Shousha S, Backhous CM, Alaghband-Zadeh J, Burn I. Alveolar variant of invasive lobular carcinoma of the breast. A tumor rich in estrogen receptors. Am J Clin Pathol 1986;85:1-5.","journal-title":"Am J Clin Pathol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/ijc.2910400221","article-title":"Expression of the c-erbB-2 protein in normal and transformed cells","volume":"40","year":"1987","unstructured":"Gullick WJ, Berger MS, Bennett PLP, Rothbard JB, Waterfield MD. Expression of the c-erbB-2 protein in normal and transformed cells. Int J Cancer 1987;40: 246-54.","journal-title":"Int J Cancer"},{"key":"ref_29","first-page":"7159","article-title":"Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of","volume-title":"NIH 3T3 cells. Proc Natl Acad Sci USA","volume":"84","author":"Hudziak, R.M.; Schlessinger, J.; Ullrich, A.","year":"1987","unstructured":"Hudziak RM, Schlessinger J, Ullrich A. Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc Natl Acad Sci USA 1987;84:7159-63."},{"key":"ref_30","first-page":"5102","article-title":"Amplified expression of the HER2\/ERBB2 oncogene induces resistance to tumor necrosis factor alpha","volume-title":"NIH 3T3 cells. Proc Natl Acad Sci","volume":"85","author":"Hudziak, R.M.; Lewis, G.D.; Shalaby, M.R.","year":"1988","unstructured":"Hudziak RM, Lewis GD, Shalaby MR, et al. Amplified expression of the HER2\/ERBB2 oncogene induces resistance to tumor necrosis factor alpha in NIH 3T3 cells. Proc Natl Acad Sci USA 1988;85:5102-6."},{"issue":"1","key":"ref_31","first-page":"165","article-title":"pl85HER2 monoclonal antibody has antiproliferative effects in vitro. and sensitizes human breast tumor cells to tumor necrosis factor","volume":"9","author":"Hudziak, R.M.; Lewis, G.D.; Winget, M.; Fendly, B.M.; Shepard, H.M.; Ullrich, A.","year":"1989","unstructured":"Hudziak RM, Lewis GD, Winget M, Fendly BM, Shepard HM, Ullrich A. pl85HER2 monoclonal antibody has antiproliferative effects in vitro. and sensitizes human breast tumor cells to tumor necrosis factor. Mol Cell Biol 1989;9:1 165-72.","journal-title":"Mol Cell Biol"},{"key":"ref_32","first-page":"383","article-title":"Immunohistochemical localization of c-erbB-2 in human breast carcinomas","volume":"2","author":"Gusterson, B.A.; Gullick, W.J.; Venter, D.J.","year":"1988","unstructured":"Gusterson BA, Gullick WJ, Venter DJ, et al. Immunohistochemical localization of c-erbB-2 in human breast carcinomas. Mol Cell Probes 1988;2:383-91.","journal-title":"Mol Cell Probes"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1002\/ijc.2910440604","article-title":"The subcellular localization of the neu protein in human normal and neoplastic cells","volume":"44","author":"CR, De Potter; J, Quatacker; G, Maertens","year":"1989","unstructured":"De Potter CR, Quatacker J, Maertens G. The subcellular localization of the neu protein in human normal and neoplastic cells. Int J Cancer 1989;44:969-74.","journal-title":"Int J Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1136\/jcp.42.9.902","article-title":"Oestrogen receptors in mucinous carcinoma of the breast: an immunohistological study using paraffin wax sections","volume":"42","author":"Shousha, S.; Coady, A.T.; Stamp, T.; James, K.R.; AlaghbandZadeh, J.","year":"1989","unstructured":"Shousha S, Coady AT, Stamp T, James KR, AlaghbandZadeh J. Oestrogen receptors in mucinous carcinoma of the breast: an immunohistological study using paraffin wax sections. J Clin Pathol 1989;42:902-5.","journal-title":"J Clin Pathol"},{"key":"ref_35","first-page":"6675","article-title":"Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras protooncogenes and clinical association in human breast carcinomas","volume":"49","author":"Garcia, I.; Dietrich, P.-Y.; Aapro, M.; Vauthier, G.; Vadas, L.; Engel, E.","year":"1989","unstructured":"Garcia I, Dietrich P-Y, Aapro M, Vauthier G, Vadas L, Engel E. Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras protooncogenes and clinical association in human breast carcinomas. Cancer Res 1989;49:6675-9.","journal-title":"Cancer Res"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0753-3322(89)90082-6","article-title":"Correlation oferbB-2 gene amplification with low levels of estrogen and\/or progesterone receptors in primary breast cancer: do erbB-2 products delineate hormone-independent tumors?","volume":"43","author":"Roux-Dosseto, M.; Romain, S.; Dussault, N.; Martin, P.M.","year":"1989","unstructured":"Roux-Dosseto M, Romain S, Dussault N, Martin PM. Correlation oferbB-2 gene amplification with low levels of estrogen and\/or progesterone receptors in primary breast cancer: do erbB-2 products delineate hormone-independent tumors? Biomed Pharmacother 1989;43:641-9.","journal-title":"Biomed Pharmacother"},{"key":"ref_37","first-page":"2087","article-title":"Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer","volume":"49","author":"Wright, C.; Angus, B.; Nicholson, S.","year":"1989","unstructured":"Wright C, Angus B, Nicholson S, et al. Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer. Cancer Res 1989;49:2087-90.","journal-title":"Cancer Res"},{"key":"ref_38","first-page":"160","article-title":"Amplification of the c-erbB-2 oncogene and prognosis of breast adenocarcinoma","volume":"114","author":"Heintz, N.H.; Leslie, K.O.; Rogers, L.A.; Howard, P.L.","year":"1990","unstructured":"Heintz NH, Leslie KO, Rogers LA, Howard PL. Amplification of the c-erbB-2 oncogene and prognosis of breast adenocarcinoma. Arch Pathol Lab Med 1990;114:160-3.","journal-title":"Arch Pathol Lab Med"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01612634","article-title":"c-erbB2 expression in correlation to other biological parameters ofbreast cancer","volume":"116","author":"Marx, D.; Schauer, A.; Chr, Reiche","year":"1990","unstructured":"Marx D, Schauer A, Reiche Chr, et al. c-erbB2 expression in correlation to other biological parameters ofbreast cancer. J Cancer Res Clin Oncol 1990;116:15-20.","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/ijc.2910420608","article-title":"Immunohistochemical distribution ofc-erbB-2in infiltratingand in situ breast cancer","volume":"42","author":"Gusterson, B.A.; Machin, L.G.; Gullick, W.J.","year":"1988","unstructured":"Gusterson BA, Machin LG, Gullick WJ, et al. Immunohistochemical distribution ofc-erbB-2in infiltratingand in situ breast cancer. Int J Cancer 1988;42:842-5.","journal-title":"Int J Cancer"},{"key":"ref_41","first-page":"6941","article-title":"c-erbB-2 amplification in node negative human breast cancer","volume":"49","author":"Ro, J.; El-Naggar, A.; Ro, J.Y.","year":"1989","unstructured":"Ro J, El-Naggar A, Ro JY, et al. c-erbB-2 amplification in node negative human breast cancer. Cancer Res 1989; 49:6941-4.","journal-title":"Cancer Res"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/path.1711610104","article-title":"Immunohistochemical distribution of c-erbB-2 in in situ breast carcinoma-A detailed morphological analysis","volume":"161","author":"Ramachandra, S.; Machin, L.; Ashley, S.; Monaghan, P.; Gusterson, B.A.","year":"1990","unstructured":"Ramachandra S, Machin L, Ashley S, Monaghan P, Gusterson BA. Immunohistochemical distribution of c-erbB-2 in in situ breast carcinoma-A detailed morphological analysis. JPathol 1990;161:7-14.","journal-title":"JPathol"},{"key":"ref_43","first-page":"504","article-title":"An immunohistochemical study of the presence of c-erbB-2 protein in Paget's disease of the nipple","volume":"15","author":"Lammie, G.A.; Barnes, D.M.; Millis, R.R.; Gullick, W.J.","year":"1989","unstructured":"Lammie GA, Barnes DM, Millis RR, Gullick WJ. An immunohistochemical study of the presence of c-erbB-2 protein in Paget's disease of the nipple. Histopathology 1989;15:504-14.","journal-title":"Histopathology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2559.1990.tb00714.x","article-title":"c-erbB-2 oncoprotein expression in mammary and extramammary Paget's disease: an immunohistochemical study","volume":"17","author":"Keatings, L.; Sinclair, J.; Wright, C.","year":"1990","unstructured":"Keatings L, Sinclair J, Wright C, et al. c-erbB-2 oncoprotein expression in mammary and extramammary Paget's disease: an immunohistochemical study. 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