{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:01:07Z","timestamp":1770998467824,"version":"3.50.1"},"reference-count":12,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:p>The effects of carbamazepine monotherapy were investigated in 20 female and 21 male epileptic patients to determine whether treatment would induce an increase in serum alkaline phosphatase (ALP) activity, a known effect of many anticonvulsant drugs. Serum total ALP activity was increased in nine out of the 41 patients (22%), serum bone ALP activity was increased in 10 (24%), and serum non-bone ALP activity was increased in three (7%). There was no significant difference when the mean of the patients' serum total ALP was compared with that of the controls. Twenty per cent of the patients with increased serum bone ALP had normal serum total ALP, indicating that increased serum bone isoenzyme activity may precede an increase in the total enzyme activity. This should be considered when interpreting results of increased total ALP in epileptic patients.<\/jats:p>","DOI":"10.1136\/jcp.44.6.480","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"480-482","source":"Crossref","is-referenced-by-count":21,"title":["Isoenzymes of alkaline phosphatase in epileptic patients receiving carbamazepine monotherapy."],"prefix":"10.1136","volume":"44","author":[{"given":"A B","family":"Okesina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P T","family":"Lascelles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/bmj.4.5727.73","article-title":"Disturbances of calcium metabolism by anticonvulsant drugs","volume":"4","author":"Richens, A.; Rowe, D.J.F.","year":"1970","unstructured":"Richens A, Rowe DJF. Disturbances of calcium metabolism by anticonvulsant drugs. Br Med J 1970;4:73-6.","journal-title":"Br Med J"},{"key":"ref_2","first-page":"907","article-title":"Interference des contraceptifs oraux et des anti-epletiques sur les parametres plasmatiques chez l'homme. Etude particuliere des enzymes","volume":"29","author":"Siest, G.; Bati, A.M.; Galtean, M.M.","year":"1974","unstructured":"Siest G, Bati AM, Galtean MM. Interference des contraceptifs oraux et des anti-epletiques sur les parametres plasmatiques chez l'homme. Etude particuliere des enzymes. Therapie 1974;29:907-14.","journal-title":"Therapie"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0009-8981(76)90080-2","article-title":"Serum gamma glutamyl transferase and alkaline phosphatase activities in epileptics receiving anticonvulsant therapy","volume":"72","author":"Skillen, A.W.; Pierides, A.M.","year":"1976","unstructured":"Skillen AW, Pierides AM. Serum gamma glutamyl transferase and alkaline phosphatase activities in epileptics receiving anticonvulsant therapy. Clin Chim Acta 1976;72:245-5 1.","journal-title":"Clin Chim Acta"},{"key":"ref_4","first-page":"282","article-title":"Biochemical evidence for osteomalacia with carbamazepine therapy","volume":"62","author":"O'Hare, J.A.; Duggan, B.; O'Driscoll, D.; Callaghan, N.","year":"1980","unstructured":"O'Hare JA, Duggan B, O'Driscoll D, Callaghan N. Biochemical evidence for osteomalacia with carbamazepine therapy. Acta Neurol Scand 1980;62:282-6.","journal-title":"Acta Neurol Scand"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/BF00450552","article-title":"The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase","volume":"237","author":"Aldenhovel, H.G.","year":"1988","unstructured":"Aldenhovel HG. The influence of long-term anticonvulsant therapy with diphenylhydantoin and carbamazepine on serum gamma-glutamyltransferase aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase. Eur Arch Psychiatr Neurol Sci 1988;237:312-6.","journal-title":"Eur Arch Psychiatr Neurol Sci"},{"key":"ref_6","first-page":"191","article-title":"German Society for Clinical Chemistry. Standard method for the determination of alkaline phosphatase activity","volume":"10","year":"1972","unstructured":"German Society for Clinical Chemistry. Standard method for the determination of alkaline phosphatase activity. Z Klin Chem Klin Biochem 1972;10: 191.","journal-title":"Z Klin Chem Klin Biochem"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/clinchem\/30.7.1182","article-title":"Foo AY. Two new methods for separating and quantifying bone and liver alkaline phosphatase isoenzyme in plasma","volume":"30","author":"Rosalki, S.B.","year":"1984","unstructured":"Rosalki SB, Foo AY. Two new methods for separating and quantifying bone and liver alkaline phosphatase isoenzyme in plasma. Clin Chem 1984;30:1182-6.","journal-title":"Clin Chem"},{"key":"ref_8","first-page":"11","article-title":"Simplified wheat germ lectin precipitation method for alkaline phosphatase isoenzyme","volume":"1","author":"Rosalki, S.B.; Foo, A.Y.","year":"1986","unstructured":"Rosalki SB, Foo AY. Simplified wheat germ lectin precipitation method for alkaline phosphatase isoenzyme. Clin Chem 1986;1: 11.","journal-title":"Clin Chem"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1093\/clinchem\/32.10.1960","article-title":"Quantification of bone alkaline phosphatase in serum by precipitation with wheat-germ lectin. A simplified method and its clinical plausibility","volume":"32","author":"Behr, W.; Bamet, J.","year":"1986","unstructured":"Behr W, Bamet J. Quantification of bone alkaline phosphatase in serum by precipitation with wheat-germ lectin. A simplified method and its clinical plausibility. Clin Chem 1986;32: 1960-6.","journal-title":"Clin Chem"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1528-1157.1975.tb06062.x","article-title":"Chronic Antiepileptic toxicity","volume":"16","author":"Reynolds, E.H.","year":"1975","unstructured":"Reynolds EH. Chronic Antiepileptic toxicity. Epilepsia 1975;16:319-52.","journal-title":"Epilepsia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/bmj.4.5727.69","article-title":"Osteomalacia with long-term anticonvulsant therapy in epilepsy","volume":"4","author":"Dent, C.E.; Richens, A.; Rowe, D.J.F.; Stamp, T.C.B.","year":"1970","unstructured":"Dent CE, Richens A, Rowe DJF, Stamp TCB. Osteomalacia with long-term anticonvulsant therapy in epilepsy. Br Med J 1970;4:69-72.","journal-title":"Br Med J"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/00002826-198506000-00003","article-title":"Factors influencing the relationship between carbamazepine plasma concentration and its clinical effects in patients with epilepsy","volume":"8","author":"Rapeport, W.G.","year":"1985","unstructured":"Rapeport WG. Factors influencing the relationship between carbamazepine plasma concentration and its clinical effects in patients with epilepsy. Clin Neuropharmacol 1985;8: 141-9.","journal-title":"Clin Neuropharmacol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.44.6.480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:00:40Z","timestamp":1758816040000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.44.6.480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":12,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1991,6,1]]},"published-print":{"date-parts":[[1991,6]]}},"alternative-id":["10.1136\/jcp.44.6.480"],"URL":"https:\/\/doi.org\/10.1136\/jcp.44.6.480","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}