{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:32:51Z","timestamp":1784194371390,"version":"3.55.0"},"reference-count":3,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:p>A 25 year old, human immunodeficiency virus (HIV) seropositive, severe haemophilic patient was treated for suspected Pneumocystis carinii infection with high dose intravenous cotrimoxazole and subsequently with prednisolone. When he improved he was discharged on oral treatment only to return two days later, extremely unwell, with headaches, fever, sweats, tachycardia and hypotension. A lumbar puncture showed modest neutrophil pleocytosis but despite empirical antibiotic treatment with intravenous benzylpenicillin and cefuroxime he continued to deteriorate. Culture of cerebrospinal fluid subsequently grew Enterococcus faecalis that was resistant to trimethoprim and sensitive to ampicillin, rifampicin, and vancomycin. After a change in treatment to intravenous ampicillin and rifampicin he dramatically improved. Enterococcal meningitis is rare in adults but important to recognise and treat appropriately in view of its high mortality and relative resistance to antibiotics. In our case the combination of HIV infection and previous treatment with antibiotics or steroids, or both, were probable predisposing factors.<\/jats:p>","DOI":"10.1136\/jcp.44.7.608","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"608-609","source":"Crossref","is-referenced-by-count":6,"title":["Enterococcal meningitis in an HIV positive haemophilic patient."],"prefix":"10.1136","volume":"44","author":[{"given":"W N","family":"Patton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Bienz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I M","family":"Franklin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J G","family":"Hastings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1991,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archinte.1976.03630080025009","article-title":"Enterococcal meningitis: Clinical and therapeutic considerations with report of three cases and review of the literature","volume":"136","author":"Bayer, A.S.; Seidel, J.S.; Yoshikawa, T.T.; Anthony, B.F.; Group, Guze L.B.; D.","year":"1976","unstructured":"Bayer AS, Seidel JS, Yoshikawa TT, Anthony BF, Guze LB. Group D Enterococcal meningitis: Clinical and therapeutic considerations with report of three cases and review of the literature. Arch Intern Med 1976;136: 883-6.","journal-title":"Arch Intern Med"},{"key":"ref_2","first-page":"1550","article-title":"Enterococcus species and group D streptococci","volume-title":"Principles and Practice of infectious diseases","author":"Musher, D.M.","year":"1990","unstructured":"Musher DM. Enterococcus species and group D streptococci. In Mandell GL, Douglas RG, Bennett JE, eds. Principles and Practice of infectious diseases. New York: Churchill Livingstone, 1990:1550-4."},{"key":"ref_3","first-page":"\"679","article-title":"Bacterial sepsis and meningitis","volume":"44","author":"Klein, J.O.; Marcy, S.M.","year":"1983","unstructured":"Klein JO, Marcy SM. Bacterial sepsis and meningitis. In: Remington JS, Klein JD, eds. Infectious diseases of the fetus and new born infant. Philadelphia: WB Saunders, 1983:679-734. J Clin Pathol 1991;44:609-610","journal-title":"J Clin Pathol; diseases of the fetus and new born infant"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jcp.44.7.608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T04:47:34Z","timestamp":1765601254000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jcp.44.7.608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":3,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1991,7,1]]},"published-print":{"date-parts":[[1991,7]]}},"alternative-id":["10.1136\/jcp.44.7.608"],"URL":"https:\/\/doi.org\/10.1136\/jcp.44.7.608","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}