{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:40:01Z","timestamp":1758915601422,"version":"3.44.0"},"reference-count":20,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:p>Twenty eight out of 170 consecutive cases of acute lymphoblastic leukaemia (ALL) were examined. They were of T cell origin, with the following distribution: seven (28%) cases had pre-T or prothymic features; nine (36%) cases showed early thymocytic features, six (24%) had cortical features; and three (12%) had a \"mature\" phenotype. The remaining three cases could not be sub-classified. A striking finding was that pre-T ALL differed from intrathymic ALL not only in the absence of both E rosettes and intrathymic differentiation antigens, but also in the expression of two non-lineage specific antigens HLA-DR and CD10. Both antigens appear in the bone marrow from the very first stages of lymphoid differentiation, implying that the origin for pre-T ALL is bone marrow. A comparison of the clinical features of pre-T and thymic ALL showed that pre-T ALL disease showed a pattern more similar to non-T ALL disease: a lower incidence of mediastinal mass, absence of extrahaematopoietic disease, lower white cell counts and haemoglobin concentrations, and a higher incidence of bone pain. No obvious difference in response to treatment was apparent. The results show that T-ALL is not only a heterogeneous immunological group but also suggest that it may have different origins: bone marrow for pre-T ALL and the thymus for thymic ALL.<\/jats:p>","DOI":"10.1136\/jcp.44.8.628","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"628-631","source":"Crossref","is-referenced-by-count":5,"title":["Heterogeneity of T cell lymphoblastic leukaemias."],"prefix":"10.1136","volume":"44","author":[{"given":"E","family":"G\u00f3mez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J F","family":"San Miguel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Orfao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"L\u00f3pez-Berges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"R\u00edos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"L\u00f3pez Borrasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1991,8,1]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Immunologic classification of leukemia and lymphoma","volume":"68","author":"Foon, K.A.; RF, III, Todd","year":"1986","unstructured":"Foon KA, Todd RF III. Immunologic classification of leukemia and lymphoma. Blood 1986;68:1-31.","journal-title":"Blood"},{"article-title":"T cell acute lymphoblastic leukemia: a report of 60 patients from India. Oncology 1985; 42: 282-6. Other markers, such as the absence of CD33","author":"Advani, S.H.; Kamat, D.M.; Rao, D.N.","key":"ref_2","unstructured":"Advani SH, Kamat DM, Rao DN, et al. T cell acute lymphoblastic leukemia: a report of 60 patients from India. Oncology 1985;42:282-6. 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