{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T16:15:42Z","timestamp":1765728942460,"version":"3.48.0"},"reference-count":11,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:p>Splenic lymphoma with villous lymphocytes is a new entity characterised by the presence of atypical lymphocytes in the peripheral blood and bone marrow, and splenic infiltration in the white and red pulp. Cell membrane markers are those of a B mature cell, and no particular chromosomal abnormalities have been associated with this disease. A case of this rare lymphoma occurred in two sisters. Histological examination of splenic tissue was identical in both cases, with the same immunological surface markers, although the clinical and laboratory features were different. Karyotype analysis showed an abnormal pattern in one case; no environmental causative factor could be detected. Familial cases of other lymphoproliferative disorders have been reported, but no consistent common link has been found. It is suggested that further reports of this lymphoma, including cytogenetic and molecular studies, may provide a better understanding of the aetiology.<\/jats:p>","DOI":"10.1136\/jcp.45.12.1111","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"1111-1113","source":"Crossref","is-referenced-by-count":8,"title":["Splenic lymphoma with villous lymphocytes in two sisters."],"prefix":"10.1136","volume":"45","author":[{"given":"I","family":"Ribeiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B A","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Parreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L S","family":"Uva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1136\/jcp.40.6.642","article-title":"Splenic B cell lymphoma with circulating villous lymphocytes: differential diagnosis of B cell leukaemias with large spleens","volume":"40","author":"Melo, J.V.; Hedge, V.; Parreira, A.; Thompson, I.; Lampert, I.A.; Catovsky, D.","year":"1987","unstructured":"Melo JV, Hedge V, Parreira A, Thompson I, Lampert IA, Catovsky D. Splenic B cell lymphoma with circulating villous lymphocytes: differential diagnosis of B cell leukaemias with large spleens. Clin Pathol 1987;40 642-51.","journal-title":"Clin Pathol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/jcp.42.6.567","article-title":"The FrenchAmerican-British (FAB) cooperative group proposals for the classification of chronic (mature) B and T lymphoid leukaemias","volume":"42","author":"Bennet, J.M.; Catovsky, D.; Daniel, M.T.","year":"1989","unstructured":"Bennet JM, Catovsky D, Daniel MT, et al. The FrenchAmerican-British (FAB) cooperative group proposals for the classification of chronic (mature) B and T lymphoid leukaemias. Clin Pathol 1989;42:567-84.","journal-title":"Clin Pathol"},{"key":"ref_3","first-page":"25","article-title":"Splenomegalic immunocytoma with circulating hairy cells. Report of eight cases and revision of the literature","volume":"71","author":"Spriano, P.; Barose, G.; Invernezzi, R.","year":"1986","unstructured":"Spriano P, Barose G, Invernezzi R, et al. Splenomegalic immunocytoma with circulating hairy cells. Report of eight cases and revision of the literature. Haematologica 1986;71:25-33.","journal-title":"Haematologica"},{"issue":"43","key":"ref_4","first-page":"329","article-title":"Malignant lymphoma simulating leukaemic reticulothendotheliosis. A clinicopathologic study of ten cases","volume":"1979","author":"Neiman, R.S.; Sullivan, A.L.; Jaffe, R.","unstructured":"Neiman RS, Sullivan AL, Jaffe R. Malignant lymphoma simulating leukaemic reticulothendotheliosis. A clinicopathologic study of ten cases. 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Cancer 1981;48: 1825-9.","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/1097-0142(19820201)49:3<538::AID-CNCR2820490323>3.0.CO;2-6","article-title":"Hairy cell leukaemia in three siblings: an apparent HLA linked disease","volume":"49","author":"Wylin, R.F.; Greene, M.H.; Palutke, M.; Khilanani, P.; Tabaczka, P.; Swiderski, G.","year":"1982","unstructured":"Wylin RF, Greene MH, Palutke M, Khilanani P, Tabaczka P, Swiderski G. Hairy cell leukaemia in three siblings: an apparent HLA linked disease. 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