{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:09:29Z","timestamp":1770822569007,"version":"3.50.1"},"reference-count":6,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:p>A 48 year old man presented with invasive adenocarcinoma in the wall of a non-healing anal fistula. The subsequent abdomino-perineal resection specimen showed residual invasive carcinoma coexisting with in situ carcinoma of anal glands as well as in situ squamous carcinoma of the anal canal. The epithelium of the anal canal had koilocytotic features. DNA hybridisation studies by the dot blot technique showed weak positivity for human papillomavirus (HPV) subtypes 16, 18. This case illustrates a number of important points--namely, anal fistulas, particularly non-healing fistulas should be biopsied to exclude malignancy; some adenocarcinomas of the anal arise in anal glands; the coexistence of glandular and squamous carcinoma with evidence of HPV infection is highly reminiscent of similar synchronous lesions of the uterine cervix and suggests that HPV may have an aetiological role in both squamous and glandular carcinomas of the anal canal.<\/jats:p>","DOI":"10.1136\/jcp.45.3.261","type":"journal-article","created":{"date-parts":[[2007,6,9]],"date-time":"2007-06-09T00:50:46Z","timestamp":1181350246000},"page":"261-263","source":"Crossref","is-referenced-by-count":10,"title":["Synchronous squamous and glandular neoplasia of the anal canal."],"prefix":"10.1136","volume":"45","author":[{"given":"M L","family":"Yeong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K P","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1992,3,1]]},"reference":[{"key":"ref_1","first-page":"45","article-title":"Anal canal tumours and their precursors. Pathology Annual Part 1","author":"Fenger, C.","year":"1988","unstructured":"Fenger C. Anal canal tumours and their precursors. Pathology Annual Part 1. East Norwalk, Connecticut: Appleton & Lange, 1988:45-66."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1136\/bmj.297.6643.239","article-title":"Changing nature of anal cancer","volume":"297","author":"Talbot, R.","year":"1988","unstructured":"Talbot R. Changing nature of anal cancer. BMJ 1988;297:239-40.","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00003081-198903000-00018","article-title":"Diagnosis of human papilloma virus infection by recombinant DNA techniques","volume":"32","author":"Schneider, A.; Grubert, T.","year":"1989","unstructured":"Schneider A, Grubert T. Diagnosis of human papilloma virus infection by recombinant DNA techniques. Clin Obstet Gynaecol 1989;32:127-40.","journal-title":"Clin Obstet Gynaecol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/jso.2930230407","article-title":"Carcinoma of the anal gland; case report and review of the literature","volume":"23","author":"Zaren, H.A.; Delone, F.X.; Lerner, H.J.","year":"1983","unstructured":"Zaren HA, Delone FX, Lerner HJ. Carcinoma of the anal gland; case report and review of the literature. J Surg Oncol 1983;23:250-4.","journal-title":"J Surg Oncol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1001\/archsurg.1985.01390290106019","article-title":"Anal carcinoma presenting as a perirectal abscess or fistula","volume":"120","author":"Nelson, R.L.; Prasad, M.L.; Abcarian, H.","year":"1985","unstructured":"Nelson RL, Prasad ML, Abcarian H. Anal carcinoma presenting as a perirectal abscess or fistula. Arch Surg 1985;120:632-5.","journal-title":"Arch Surg"},{"key":"ref_6","first-page":"263","article-title":"Premalignant and malignant disease of the cervix. Obstetrical and gynaecological pathology Vol I","volume":"45","author":"Anderson, M.C.","year":"1987","unstructured":"Anderson MC. Premalignant and malignant disease of the cervix. Obstetrical and gynaecological pathology Vol I 3rd ed. Edinburgh: Churchill Livingstone, 1987:289. 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